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LDHA (lactate dehydrogenase A)

Identity

Other namesGSD11
HEL-S-133P
LDHM
PIG19
HGNC (Hugo) LDHA
LocusID (NCBI) 3939
Atlas_Id 41136
Location 11p15.1
Location_base_pair Starts at 18415936 and ends at 18429765 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BOLA2 (16p11.2) / LDHA (11p15.1)GORASP2 (2q31.1) / LDHA (11p15.1)LDHA (11p15.1) / ATP5G3 (2q31.1)
LDHA (11p15.1) / EIF4EBP2 (10q22.1)LDHA (11p15.1) / MEST (7q32.2)LDHA (11p15.1) / WIPI2 (7p22.1)
Metazoa_SRP () / LDHA (11p15.1)PRPF8 (17p13.3) / LDHA (11p15.1)SKI (1p36.33) / LDHA (11p15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LDHA   6535
Cards
Entrez_Gene (NCBI)LDHA  3939  lactate dehydrogenase A
AliasesGSD11; HEL-S-133P; LDHM; PIG19
GeneCards (Weizmann)LDHA
Ensembl hg19 (Hinxton)ENSG00000134333 [Gene_View]  chr11:18415936-18429765 [Contig_View]  LDHA [Vega]
Ensembl hg38 (Hinxton)ENSG00000134333 [Gene_View]  chr11:18415936-18429765 [Contig_View]  LDHA [Vega]
ICGC DataPortalENSG00000134333
TCGA cBioPortalLDHA
AceView (NCBI)LDHA
Genatlas (Paris)LDHA
WikiGenes3939
SOURCE (Princeton)LDHA
Genomic and cartography
GoldenPath hg19 (UCSC)LDHA  -     chr11:18415936-18429765 +  11p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LDHA  -     11p15.1   [Description]    (hg38-Dec_2013)
EnsemblLDHA - 11p15.1 [CytoView hg19]  LDHA - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBILDHA [Mapview hg19]  LDHA [Mapview hg38]
OMIM150000   612933   
Gene and transcription
Genbank (Entrez)AK026515 AK130035 AK130105 AK130587 AK223078
RefSeq transcript (Entrez)NM_001135239 NM_001165414 NM_001165415 NM_001165416 NM_005566
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_008185 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)LDHA
Cluster EST : UnigeneHs.2795 [ NCBI ]
CGAP (NCI)Hs.2795
Alternative Splicing GalleryENSG00000134333
Gene ExpressionLDHA [ NCBI-GEO ]   LDHA [ EBI - ARRAY_EXPRESS ]   LDHA [ SEEK ]   LDHA [ MEM ]
Gene Expression Viewer (FireBrowse)LDHA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3939
GTEX Portal (Tissue expression)LDHA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00338 (Uniprot)
NextProtP00338  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00338
Splice isoforms : SwissVarP00338 (Swissvar)
Catalytic activity : Enzyme1.1.1.27 [ Enzyme-Expasy ]   1.1.1.271.1.1.27 [ IntEnz-EBI ]   1.1.1.27 [ BRENDA ]   1.1.1.27 [ KEGG ]   
PhosPhoSitePlusP00338
Domaine pattern : Prosite (Expaxy)L_LDH (PS00064)   
Domains : Interpro (EBI)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (NCBI)pfam02866    pfam00056   
DMDM Disease mutations3939
Blocks (Seattle)LDHA
PDB (SRS)1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
PDB (PDBSum)1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
PDB (IMB)1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
PDB (RSDB)1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
Structural Biology KnowledgeBase1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
SCOP (Structural Classification of Proteins)1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
CATH (Classification of proteins structures)1I10    4AJP    4JNK    4L4R    4L4S    4M49    4OJN    4OKN    4QO7    4QO8    4QSM    4QT0    4R68    4R69    4RLS   
SuperfamilyP00338
Human Protein AtlasENSG00000134333
Peptide AtlasP00338
HPRD01025
IPIIPI00217966   IPI00607708   IPI00908791   IPI00947127   IPI00952964   IPI00939286   IPI01012528   IPI01010154   IPI00910754   IPI01014582   IPI01010632   IPI01014829   IPI01014404   IPI01015723   IPI01013874   IPI01013456   IPI01011334   
Protein Interaction databases
DIP (DOE-UCLA)P00338
IntAct (EBI)P00338
FunCoupENSG00000134333
BioGRIDLDHA
STRING (EMBL)LDHA
ZODIACLDHA
Ontologies - Pathways
QuickGOP00338
Ontology : AmiGOresponse to hypoxia  L-lactate dehydrogenase activity  L-lactate dehydrogenase activity  protein binding  nucleus  cytosol  lactate metabolic process  pyruvate metabolic process  glycolytic process  response to nutrient  response to glucose  membrane  NAD metabolic process  kinase binding  substantia nigra development  response to drug  response to hydrogen peroxide  identical protein binding  positive regulation of apoptotic process  response to estrogen  post-embryonic organ development  NAD binding  response to cAMP  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIresponse to hypoxia  L-lactate dehydrogenase activity  L-lactate dehydrogenase activity  protein binding  nucleus  cytosol  lactate metabolic process  pyruvate metabolic process  glycolytic process  response to nutrient  response to glucose  membrane  NAD metabolic process  kinase binding  substantia nigra development  response to drug  response to hydrogen peroxide  identical protein binding  positive regulation of apoptotic process  response to estrogen  post-embryonic organ development  NAD binding  response to cAMP  oxidation-reduction process  extracellular exosome  
Pathways : BIOCARTAHypoxia-Inducible Factor in the Cardiovascular System [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    Cysteine and methionine metabolism    Pyruvate metabolism    Propanoate metabolism    HIF-1 signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkLDHA
Wikipedia pathwaysLDHA
Orthology - Evolution
OrthoDB3939
GeneTree (enSembl)ENSG00000134333
Phylogenetic Trees/Animal Genes : TreeFamLDHA
Homologs : HomoloGeneLDHA
Homology/Alignments : Family Browser (UCSC)LDHA
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLDHA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LDHA
dbVarLDHA
ClinVarLDHA
1000_GenomesLDHA 
Exome Variant ServerLDHA
ExAC (Exome Aggregation Consortium)LDHA (select the gene name)
Genetic variants : HAPMAP3939
Genomic Variants (DGV)LDHA [DGVbeta]
Mutations
ICGC Data PortalLDHA 
TCGA Data PortalLDHA 
Broad Tumor PortalLDHA
OASIS PortalLDHA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLDHA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LDHA
DgiDB (Drug Gene Interaction Database)LDHA
DoCM (Curated mutations)LDHA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LDHA (select a term)
intoGenLDHA
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:18415936-18429765  ENSG00000134333
CONAN: Copy Number AnalysisLDHA 
Mutations and Diseases : HGMDLDHA
OMIM150000    612933   
MedgenLDHA
Genetic Testing Registry LDHA
NextProtP00338 [Medical]
TSGene3939
GENETestsLDHA
Huge Navigator LDHA [HugePedia]
snp3D : Map Gene to Disease3939
BioCentury BCIQLDHA
ClinGenLDHA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3939
Chemical/Pharm GKB GenePA30319
Clinical trialLDHA
Miscellaneous
canSAR (ICR)LDHA (select the gene name)
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLDHA
EVEXLDHA
GoPubMedLDHA
iHOPLDHA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:08:35 CEST 2016

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