LDHA (lactate dehydrogenase A)

2003-08-01  

Identity

HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
GSD11,HEL-S-133P,LDHM,PIG19
FUSION GENES

Other Information

Locus ID:

NCBI: 3939
MIM: 150000
HGNC: 6535
Ensembl: ENSG00000134333

Variants:

dbSNP: 3939
ClinVar: 3939
TCGA: ENSG00000134333
COSMIC: LDHA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134333ENST00000227157P00338
ENSG00000134333ENST00000379412P00338
ENSG00000134333ENST00000379412V9HWB9
ENSG00000134333ENST00000396222P00338
ENSG00000134333ENST00000422447P00338
ENSG00000134333ENST00000422447V9HWB9
ENSG00000134333ENST00000430553P00338
ENSG00000134333ENST00000478970F5GYU2
ENSG00000134333ENST00000486690F5GWW2
ENSG00000134333ENST00000495052F5GXH2
ENSG00000134333ENST00000535451F5GZQ4
ENSG00000134333ENST00000536528F5GXC7
ENSG00000134333ENST00000539814F5H6W8
ENSG00000134333ENST00000540430P00338
ENSG00000134333ENST00000541097F5H5J4
ENSG00000134333ENST00000542179P00338
ENSG00000134333ENST00000542179V9HWB9
ENSG00000134333ENST00000543445F5GXY2
ENSG00000134333ENST00000543695F5GXU1
ENSG00000134333ENST00000545215F5GWW2
ENSG00000134333ENST00000545467F5H8H6
ENSG00000134333ENST00000625635F5GXU1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pyruvate metabolismKEGGko00620
Propanoate metabolismKEGGko00640
Glycolysis / GluconeogenesisKEGGhsa00010
Pyruvate metabolismKEGGhsa00620
Propanoate metabolismKEGGhsa00640
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
HIF-1 signaling pathwayKEGGhsa04066
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167662622006Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.470
276410982016LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.167
192761582009LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.97
196682252009Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.82
198479242010Detecting rare variants for complex traits using family and unrelated data.79
228974812012Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma.66
161325752005Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer.62
246343812014FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression.61
219696072011Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.60
229236632012Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.58

Citation

Dessen P

LDHA (lactate dehydrogenase A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41136/ldha