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LDHA (lactate dehydrogenase A)

Identity

Other namesGSD11
HEL-S-133P
LDH1
LDHM
HGNC (Hugo) LDHA
LocusID (NCBI) 3939
Location 11p15.1
Location_base_pair Starts at 18415936 and ends at 18429765 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LDHA   6535
Cards
Entrez_Gene (NCBI)LDHA  3939  lactate dehydrogenase A
GeneCards (Weizmann)LDHA
Ensembl hg19 (Hinxton)ENSG00000134333 [Gene_View]  chr11:18415936-18429765 [Contig_View]  LDHA [Vega]
Ensembl hg38 (Hinxton)ENSG00000134333 [Gene_View]  chr11:18415936-18429765 [Contig_View]  LDHA [Vega]
ICGC DataPortalENSG00000134333
cBioPortalLDHA
AceView (NCBI)LDHA
Genatlas (Paris)LDHA
WikiGenes3939
SOURCE (Princeton)LDHA
Genomic and cartography
GoldenPath hg19 (UCSC)LDHA  -     chr11:18415936-18429765 +  11p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LDHA  -     11p15.1   [Description]    (hg38-Dec_2013)
EnsemblLDHA - 11p15.1 [CytoView hg19]  LDHA - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBILDHA [Mapview hg19]  LDHA [Mapview hg38]
OMIM150000   612933   
Gene and transcription
Genbank (Entrez)AK026515 AK130035 AK130105 AK130587 AK223078
RefSeq transcript (Entrez)NM_001135239 NM_001165414 NM_001165415 NM_001165416 NM_005566
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_008185 NT_009237 NW_001838022 NW_004929378
Consensus coding sequences : CCDS (NCBI)LDHA
Cluster EST : UnigeneHs.2795 [ NCBI ]
CGAP (NCI)Hs.2795
Alternative Splicing : Fast-db (Paris)GSHG0004680
Alternative Splicing GalleryENSG00000134333
Gene ExpressionLDHA [ NCBI-GEO ]     LDHA [ SEEK ]   LDHA [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00338 (Uniprot)
NextProtP00338  [Medical]
With graphics : InterProP00338
Splice isoforms : SwissVarP00338 (Swissvar)
Catalytic activity : Enzyme1.1.1.27 [ Enzyme-Expasy ]   1.1.1.271.1.1.27 [ IntEnz-EBI ]   1.1.1.27 [ BRENDA ]   1.1.1.27 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)L_LDH (PS00064)   
Domains : Interpro (EBI)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom   
Related proteins : CluSTrP00338
Domain families : Pfam (Sanger)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (NCBI)pfam02866    pfam00056   
DMDM Disease mutations3939
Blocks (Seattle)P00338
PDB (SRS)1I10    4AJP    4JNK    4M49   
PDB (PDBSum)1I10    4AJP    4JNK    4M49   
PDB (IMB)1I10    4AJP    4JNK    4M49   
PDB (RSDB)1I10    4AJP    4JNK    4M49   
Human Protein AtlasENSG00000134333
Peptide AtlasP00338
HPRD01025
IPIIPI00217966   IPI00607708   IPI00908791   IPI00947127   IPI00952964   IPI00939286   IPI01012528   IPI01010154   IPI00910754   IPI01014582   IPI01010632   IPI01014829   IPI01014404   IPI01015723   IPI01013874   IPI01013456   IPI01011334   
Protein Interaction databases
DIP (DOE-UCLA)P00338
IntAct (EBI)P00338
FunCoupENSG00000134333
BioGRIDLDHA
IntegromeDBLDHA
STRING (EMBL)LDHA
Ontologies - Pathways
QuickGOP00338
Ontology : AmiGOL-lactate dehydrogenase activity  protein binding  nucleus  mitochondrion  cytosol  cilium  pyruvate metabolic process  glycolytic process  membrane  substantia nigra development  cellular response to extracellular stimulus  cellular metabolic process  cellular carbohydrate metabolic process  small molecule metabolic process  oxidation-reduction process  extracellular vesicular exosome  
Ontology : EGO-EBIL-lactate dehydrogenase activity  protein binding  nucleus  mitochondrion  cytosol  cilium  pyruvate metabolic process  glycolytic process  membrane  substantia nigra development  cellular response to extracellular stimulus  cellular metabolic process  cellular carbohydrate metabolic process  small molecule metabolic process  oxidation-reduction process  extracellular vesicular exosome  
Pathways : BIOCARTAHypoxia-Inducible Factor in the Cardiovascular System [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    Cysteine and methionine metabolism    Pyruvate metabolism    Propanoate metabolism    HIF-1 signaling pathway   
Protein Interaction DatabaseLDHA
DoCM (Curated mutations)LDHA
Wikipedia pathwaysLDHA
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLDHA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LDHA
dbVarLDHA
ClinVarLDHA
1000_GenomesLDHA 
Exome Variant ServerLDHA
SNP (GeneSNP Utah)LDHA
SNP : HGBaseLDHA
Genetic variants : HAPMAPLDHA
Genomic VariantsLDHA  LDHA [DGVbeta]
Mutations
ICGC Data PortalENSG00000134333 
Somatic Mutations in Cancer : COSMICLDHA 
CONAN: Copy Number AnalysisLDHA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:18415936-18429765
Mutations and Diseases : HGMDLDHA
OMIM150000    612933   
MedgenLDHA
NextProtP00338 [Medical]
GENETestsLDHA
Disease Genetic AssociationLDHA
Huge Navigator LDHA [HugePedia]  LDHA [HugeCancerGEM]
snp3D : Map Gene to Disease3939
DGIdb (Drug Gene Interaction db)LDHA
General knowledge
Homologs : HomoloGeneLDHA
Homology/Alignments : Family Browser (UCSC)LDHA
Phylogenetic Trees/Animal Genes : TreeFamLDHA
Chemical/Protein Interactions : CTD3939
Chemical/Pharm GKB GenePA30319
Clinical trialLDHA
Cancer Resource (Charite)ENSG00000134333
Other databases
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
CoreMineLDHA
GoPubMedLDHA
iHOPLDHA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:26:16 CET 2014
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