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LDHB (lactate dehydrogenase B)

Identity

Other namesHEL-S-281
LDH-B
LDH-H
LDHBD
TRG-5
HGNC (Hugo) LDHB
LocusID (NCBI) 3945
Location 12p12.1
Location_base_pair Starts at 21788275 and ends at 21810728 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LDHB   6541
Cards
Entrez_Gene (NCBI)LDHB  3945  lactate dehydrogenase B
GeneCards (Weizmann)LDHB
Ensembl hg19 (Hinxton)ENSG00000111716 [Gene_View]  chr12:21788275-21810728 [Contig_View]  LDHB [Vega]
Ensembl hg38 (Hinxton)ENSG00000111716 [Gene_View]  chr12:21788275-21810728 [Contig_View]  LDHB [Vega]
ICGC DataPortalENSG00000111716
cBioPortalLDHB
AceView (NCBI)LDHB
Genatlas (Paris)LDHB
WikiGenes3945
SOURCE (Princeton)LDHB
Genomic and cartography
GoldenPath hg19 (UCSC)LDHB  -     chr12:21788275-21810728 -  12p12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LDHB  -     12p12.1   [Description]    (hg38-Dec_2013)
EnsemblLDHB - 12p12.1 [CytoView hg19]  LDHB - 12p12.1 [CytoView hg38]
Mapping of homologs : NCBILDHB [Mapview hg19]  LDHB [Mapview hg38]
OMIM150100   614128   
Gene and transcription
Genbank (Entrez)AB209231 AK129881 AK312328 AL516910 AY189689
RefSeq transcript (Entrez)NM_001174097 NM_002300
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_017038 NT_009714 NW_001838052 NW_004929383
Consensus coding sequences : CCDS (NCBI)LDHB
Cluster EST : UnigeneHs.446149 [ NCBI ]
CGAP (NCI)Hs.446149
Alternative Splicing : Fast-db (Paris)GSHG0007318
Alternative Splicing GalleryENSG00000111716
Gene ExpressionLDHB [ NCBI-GEO ]     LDHB [ SEEK ]   LDHB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07195 (Uniprot)
NextProtP07195  [Medical]
With graphics : InterProP07195
Splice isoforms : SwissVarP07195 (Swissvar)
Catalytic activity : Enzyme1.1.1.27 [ Enzyme-Expasy ]   1.1.1.271.1.1.27 [ IntEnz-EBI ]   1.1.1.27 [ BRENDA ]   1.1.1.27 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)L_LDH (PS00064)   
Domains : Interpro (EBI)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom   
Related proteins : CluSTrP07195
Domain families : Pfam (Sanger)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (NCBI)pfam02866    pfam00056   
DMDM Disease mutations3945
Blocks (Seattle)P07195
PDB (SRS)1I0Z    1T2F   
PDB (PDBSum)1I0Z    1T2F   
PDB (IMB)1I0Z    1T2F   
PDB (RSDB)1I0Z    1T2F   
Human Protein AtlasENSG00000111716
Peptide AtlasP07195
HPRD01026
IPIIPI00219217   IPI00556477   IPI00789173   IPI00788938   IPI01011090   
Protein Interaction databases
DIP (DOE-UCLA)P07195
IntAct (EBI)P07195
FunCoupENSG00000111716
BioGRIDLDHB
IntegromeDBLDHB
STRING (EMBL)LDHB
Ontologies - Pathways
QuickGOP07195
Ontology : AmiGOL-lactate dehydrogenase activity  protein binding  cytoplasm  cytoplasm  mitochondrion  cytosol  lactate metabolic process  pyruvate metabolic process  glycolytic process  membrane  NAD metabolic process  kinase binding  identical protein binding  cellular metabolic process  cellular carbohydrate metabolic process  small molecule metabolic process  NAD binding  oxidation-reduction process  extracellular vesicular exosome  
Ontology : EGO-EBIL-lactate dehydrogenase activity  protein binding  cytoplasm  cytoplasm  mitochondrion  cytosol  lactate metabolic process  pyruvate metabolic process  glycolytic process  membrane  NAD metabolic process  kinase binding  identical protein binding  cellular metabolic process  cellular carbohydrate metabolic process  small molecule metabolic process  NAD binding  oxidation-reduction process  extracellular vesicular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Cysteine and methionine metabolism    Pyruvate metabolism    Propanoate metabolism   
Protein Interaction DatabaseLDHB
DoCM (Curated mutations)LDHB
Wikipedia pathwaysLDHB
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLDHB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LDHB
dbVarLDHB
ClinVarLDHB
1000_GenomesLDHB 
Exome Variant ServerLDHB
SNP (GeneSNP Utah)LDHB
SNP : HGBaseLDHB
Genetic variants : HAPMAPLDHB
Genomic VariantsLDHB  LDHB [DGVbeta]
Mutations
ICGC Data PortalENSG00000111716 
Somatic Mutations in Cancer : COSMICLDHB 
CONAN: Copy Number AnalysisLDHB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:21788275-21810728
Mutations and Diseases : HGMDLDHB
OMIM150100    614128   
MedgenLDHB
NextProtP07195 [Medical]
GENETestsLDHB
Disease Genetic AssociationLDHB
Huge Navigator LDHB [HugePedia]  LDHB [HugeCancerGEM]
snp3D : Map Gene to Disease3945
DGIdb (Drug Gene Interaction db)LDHB
General knowledge
Homologs : HomoloGeneLDHB
Homology/Alignments : Family Browser (UCSC)LDHB
Phylogenetic Trees/Animal Genes : TreeFamLDHB
Chemical/Protein Interactions : CTD3945
Chemical/Pharm GKB GenePA30325
Clinical trialLDHB
Cancer Resource (Charite)ENSG00000111716
Other databases
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
CoreMineLDHB
GoPubMedLDHB
iHOPLDHB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:26:17 CET 2014

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