Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LDHB (lactate dehydrogenase B)

Identity

Other namesLDH-B
LDH-H
LDHBD
TRG-5
HGNC (Hugo) LDHB
LocusID (NCBI) 3945
Location 12p12.1
Location_base_pair Starts at 21788275 and ends at 21810728 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LDHB   6541
Entrez_Gene (NCBI)LDHB  3945  lactate dehydrogenase B
Cards
GeneCards (Weizmann)LDHB
Ensembl (Hinxton)ENSG00000111716 [Gene_View]  chr12:21788275-21810728 [Contig_View]  LDHB [Vega]
AceView (NCBI)LDHB
Genatlas (Paris)LDHB
SOURCE (Stanford)NM_001174097 NM_002300
Genomic and cartography
GoldenPath (UCSC)LDHB  -  12p12.1   chr12:21788275-21810728 -  12p12.1   [Description]    (hg19-Feb_2009)
EnsemblLDHB - 12p12.1 [CytoView]
Mapping of homologs : NCBILDHB [Mapview]
OMIM150100   614128   
Gene and transcription
Genbank (Entrez)AB209231 AK129881 AK312328 AL516910 AY189689
RefSeq transcript (SRS)NM_001174097 NM_002300
RefSeq transcript (Entrez)NM_001174097 NM_002300
RefSeq genomic (SRS)AC_000144 NC_000012 NC_018923 NG_017038 NT_009714 NW_001838052 NW_004929383
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_017038 NT_009714 NW_001838052 NW_004929383
Consensus coding sequences : CCDS (NCBI)LDHB
Cluster EST : UnigeneHs.446149 [ SRS ] Hs.446149 [ NCBI ]
CGAP (NCI)Hs.446149
Alternative Splicing : Fast-db (Paris)GSHG0007318
Alternative Splicing GalleryENSG00000111716
Gene ExpressionLDHB [ NCBI-GEO ]   LDHB [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07195 (SRS) P07195 (Uniprot)
NextProtP07195  [Medical]
With graphics : InterProP07195
Splice isoforms : SwissVarP07195(Swissvar)
Domaine pattern : Prosite (SRS)L_LDH (PS00064)   
Domaine pattern : Prosite (Expaxy)L_LDH (PS00064)   
Domains : Interpro (SRS)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom   
Domains : Interpro (EBI)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom   
Related proteins : CluSTrP07195
Domain families : Pfam (SRS)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (Sanger)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (NCBI)pfam02866    pfam00056   
DMDM3945
Blocks (Seattle)P07195
PDB (SRS)1I0Z    1T2F   
PDB (PDBSum)1I0Z    1T2F   
PDB (IMB)1I0Z    1T2F   
PDB (RSDB)1I0Z    1T2F   
Human Protein AtlasENSG00000111716
HPRD01026
IPIIPI00219217   IPI00556477   IPI00789173   IPI00788938   IPI01011090   
Protein Interaction databases
DIP (DOE-UCLA)P07195
IntAct (EBI)P07195
FunCoupENSG00000111716
REACTOMELDHB
Protein Interaction Database3945
BioGRIDLDHB
InParanoidP07195
Interologous Interaction database P07195
IntegromeDBLDHB
Gene fusion - rearrangments
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LDHB
SNP (GeneSNP Utah)LDHB
SNP : HGBaseLDHB
Genetic variants : HAPMAPLDHB
Somatic Mutations in Cancer : COSMICLDHB 
CONAN: Copy Number AnalysisLDHB 
Mutations and Diseases : HGMDLDHB
OMIM150100    614128   
GENETests150100    614128   
Disease Genetic AssociationLDHB
Huge Navigator LDHB [HugePedia]  LDHB [HugeCancerGEM]
Genomic VariantsLDHB  LDHB [DGVbeta]
ClinVarLDHB
snp3D : Map Gene to Disease3945
General knowledge
Homologs : HomoloGeneLDHB
Homology/Alignments : Family Browser (UCSC)LDHB
Phylogenetic Trees/Animal Genes : TreeFamLDHB
Catalytic activity : Enzyme1.1.1.27 [ Enzyme-Expasy ]   1.1.1.27 [ Enzyme-SRS ]   1.1.1.27 [ IntEnz-EBI ]   1.1.1.27 [ BRENDA ]   1.1.1.27 [ KEGG ]   
Chemical/Protein Interactions : CTD3945
Chemical/Pharm GKB GenePA30325
Clinical trialLDHB
Cancer Resource (Charite)ENSG00000111716
Ontology : AmiGOL-lactate dehydrogenase activity  cytoplasm  mitochondrion  cytosol  lactate metabolic process  pyruvate metabolic process  glycolysis  NAD metabolic process  kinase binding  identical protein binding  cellular metabolic process  cellular carbohydrate metabolic process  small molecule metabolic process  NAD binding  
Ontology : EGO-EBIL-lactate dehydrogenase activity  cytoplasm  mitochondrion  cytosol  lactate metabolic process  pyruvate metabolic process  glycolysis  NAD metabolic process  kinase binding  identical protein binding  cellular metabolic process  cellular carbohydrate metabolic process  small molecule metabolic process  NAD binding  
Pathways : KEGGGlycolysis / GluconeogenesisPyruvate metabolismPropanoate metabolismCysteine metabolism
Other databases
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
PubGeneLDHB
iHOPLDHB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 20:05:40 CET 2013
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