Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LDHB (lactate dehydrogenase B)

Identity

Other aliasHEL-S-281
LDH-B
LDH-H
LDHBD
TRG-5
HGNC (Hugo) LDHB
LocusID (NCBI) 3945
Atlas_Id 47310
Location 12p12.1  [Link to chromosome band 12p12]
Location_base_pair Starts at 21635342 and ends at 21657794 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		LDHB (12p12.1) / BCAR1 (16q23.1)LDHB (12p12.1) / SUPT3H (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LDHB   6541
Cards
Entrez_Gene (NCBI)LDHB  3945  lactate dehydrogenase B
AliasesHEL-S-281; LDH-B; LDH-H; LDHBD; 
TRG-5
GeneCards (Weizmann)LDHB
Ensembl hg19 (Hinxton)ENSG00000111716 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111716 [Gene_View]  chr12:21635342-21657794 [Contig_View]  LDHB [Vega]
ICGC DataPortalENSG00000111716
TCGA cBioPortalLDHB
AceView (NCBI)LDHB
Genatlas (Paris)LDHB
WikiGenes3945
SOURCE (Princeton)LDHB
Genetics Home Reference (NIH)LDHB
Genomic and cartography
GoldenPath hg38 (UCSC)LDHB  -     chr12:21635342-21657794 -  12p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LDHB  -     12p12.1   [Description]    (hg19-Feb_2009)
EnsemblLDHB - 12p12.1 [CytoView hg19]  LDHB - 12p12.1 [CytoView hg38]
Mapping of homologs : NCBILDHB [Mapview hg19]  LDHB [Mapview hg38]
OMIM150100   614128   
Gene and transcription
Genbank (Entrez)AB209231 AK129881 AK312328 AL516910 AY189689
RefSeq transcript (Entrez)NM_001174097 NM_001315537 NM_002300
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LDHB
Cluster EST : UnigeneHs.446149 [ NCBI ]
CGAP (NCI)Hs.446149
Alternative Splicing GalleryENSG00000111716
Gene ExpressionLDHB [ NCBI-GEO ]   LDHB [ EBI - ARRAY_EXPRESS ]   LDHB [ SEEK ]   LDHB [ MEM ]
Gene Expression Viewer (FireBrowse)LDHB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3945
GTEX Portal (Tissue expression)LDHB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07195   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07195  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07195
Splice isoforms : SwissVarP07195
Catalytic activity : Enzyme1.1.1.27 [ Enzyme-Expasy ]   1.1.1.271.1.1.27 [ IntEnz-EBI ]   1.1.1.27 [ BRENDA ]   1.1.1.27 [ KEGG ]   
PhosPhoSitePlusP07195
Domaine pattern : Prosite (Expaxy)L_LDH (PS00064)   
Domains : Interpro (EBI)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (NCBI)pfam02866    pfam00056   
Conserved Domain (NCBI)LDHB
DMDM Disease mutations3945
Blocks (Seattle)LDHB
PDB (SRS)1I0Z    1T2F   
PDB (PDBSum)1I0Z    1T2F   
PDB (IMB)1I0Z    1T2F   
PDB (RSDB)1I0Z    1T2F   
Structural Biology KnowledgeBase1I0Z    1T2F   
SCOP (Structural Classification of Proteins)1I0Z    1T2F   
CATH (Classification of proteins structures)1I0Z    1T2F   
SuperfamilyP07195
Human Protein AtlasENSG00000111716
Peptide AtlasP07195
HPRD01026
IPIIPI00219217   IPI00556477   IPI00789173   IPI00788938   IPI01011090   
Protein Interaction databases
DIP (DOE-UCLA)P07195
IntAct (EBI)P07195
FunCoupENSG00000111716
BioGRIDLDHB
STRING (EMBL)LDHB
ZODIACLDHB
Ontologies - Pathways
QuickGOP07195
Ontology : AmiGOL-lactate dehydrogenase activity  protein binding  cytoplasm  mitochondrion  cytosol  cytosol  carbohydrate metabolic process  lactate metabolic process  pyruvate metabolic process  membrane  NAD metabolic process  kinase binding  identical protein binding  myelin sheath  membrane raft  NAD binding  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIL-lactate dehydrogenase activity  protein binding  cytoplasm  mitochondrion  cytosol  cytosol  carbohydrate metabolic process  lactate metabolic process  pyruvate metabolic process  membrane  NAD metabolic process  kinase binding  identical protein binding  myelin sheath  membrane raft  NAD binding  oxidation-reduction process  extracellular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Cysteine and methionine metabolism    Pyruvate metabolism    Propanoate metabolism   
NDEx NetworkLDHB
Atlas of Cancer Signalling NetworkLDHB
Wikipedia pathwaysLDHB
Orthology - Evolution
OrthoDB3945
GeneTree (enSembl)ENSG00000111716
Phylogenetic Trees/Animal Genes : TreeFamLDHB
HOVERGENP07195
HOGENOMP07195
Homologs : HomoloGeneLDHB
Homology/Alignments : Family Browser (UCSC)LDHB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLDHB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LDHB
dbVarLDHB
ClinVarLDHB
1000_GenomesLDHB 
Exome Variant ServerLDHB
ExAC (Exome Aggregation Consortium)LDHB (select the gene name)
Genetic variants : HAPMAP3945
Genomic Variants (DGV)LDHB [DGVbeta]
DECIPHERLDHB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLDHB 
Mutations
ICGC Data PortalLDHB 
TCGA Data PortalLDHB 
Broad Tumor PortalLDHB
OASIS PortalLDHB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLDHB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLDHB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LDHB
DgiDB (Drug Gene Interaction Database)LDHB
DoCM (Curated mutations)LDHB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LDHB (select a term)
intoGenLDHB
Cancer3DLDHB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150100    614128   
Orphanet20611   
MedgenLDHB
Genetic Testing Registry LDHB
NextProtP07195 [Medical]
TSGene3945
GENETestsLDHB
Target ValidationLDHB
Huge Navigator LDHB [HugePedia]
snp3D : Map Gene to Disease3945
BioCentury BCIQLDHB
ClinGenLDHB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3945
Chemical/Pharm GKB GenePA30325
Clinical trialLDHB
Miscellaneous
canSAR (ICR)LDHB (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLDHB
EVEXLDHB
GoPubMedLDHB
iHOPLDHB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:40:20 CEST 2017
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