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LDHC (lactate dehydrogenase C)

Identity

Alias_symbol (synonym)CT32
Other aliasLDH3
LDHX
HGNC (Hugo) LDHC
LocusID (NCBI) 3948
Atlas_Id 47075
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 18412306 and ends at 18451246 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LDHC (11p15.1) / SERGEF (11p15.1)RGS22 (8q22.2) / LDHC (11p15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(11)(p15p15) LDHC/SERGEF


External links

Nomenclature
HGNC (Hugo)LDHC   6544
Cards
Entrez_Gene (NCBI)LDHC  3948  lactate dehydrogenase C
AliasesCT32; LDH3; LDHX
GeneCards (Weizmann)LDHC
Ensembl hg19 (Hinxton)ENSG00000166796 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166796 [Gene_View]  ENSG00000166796 [Sequence]  chr11:18412306-18451246 [Contig_View]  LDHC [Vega]
ICGC DataPortalENSG00000166796
TCGA cBioPortalLDHC
AceView (NCBI)LDHC
Genatlas (Paris)LDHC
WikiGenes3948
SOURCE (Princeton)LDHC
Genetics Home Reference (NIH)LDHC
Genomic and cartography
GoldenPath hg38 (UCSC)LDHC  -     chr11:18412306-18451246 +  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LDHC  -     11p15.1   [Description]    (hg19-Feb_2009)
EnsemblLDHC - 11p15.1 [CytoView hg19]  LDHC - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBILDHC [Mapview hg19]  LDHC [Mapview hg38]
OMIM150150   
Gene and transcription
Genbank (Entrez)AF401094 AF401095 AF401096 AF401097 AK058181
RefSeq transcript (Entrez)NM_002301 NM_017448
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LDHC
Cluster EST : UnigeneHs.654377 [ NCBI ]
CGAP (NCI)Hs.654377
Alternative Splicing GalleryENSG00000166796
Gene ExpressionLDHC [ NCBI-GEO ]   LDHC [ EBI - ARRAY_EXPRESS ]   LDHC [ SEEK ]   LDHC [ MEM ]
Gene Expression Viewer (FireBrowse)LDHC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3948
GTEX Portal (Tissue expression)LDHC
Human Protein AtlasENSG00000166796-LDHC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07864   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07864  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07864
Splice isoforms : SwissVarP07864
Catalytic activity : Enzyme1.1.1.27 [ Enzyme-Expasy ]   1.1.1.271.1.1.27 [ IntEnz-EBI ]   1.1.1.27 [ BRENDA ]   1.1.1.27 [ KEGG ]   
PhosPhoSitePlusP07864
Domaine pattern : Prosite (Expaxy)L_LDH (PS00064)   
Domains : Interpro (EBI)L-lactate/malate_DH    L-lactate_DH    L-lactate_DH_AS    Lactate/malate_DH_C    Lactate/malate_DH_N    Lactate_DH/Glyco_Ohase_4_C    NAD(P)-bd_dom_sf   
Domain families : Pfam (Sanger)Ldh_1_C (PF02866)    Ldh_1_N (PF00056)   
Domain families : Pfam (NCBI)pfam02866    pfam00056   
Conserved Domain (NCBI)LDHC
DMDM Disease mutations3948
Blocks (Seattle)LDHC
SuperfamilyP07864
Human Protein Atlas [tissue]ENSG00000166796-LDHC [tissue]
Peptide AtlasP07864
HPRD01027
IPIIPI00554498   IPI01014690   IPI01015836   IPI01015418   IPI01012697   IPI01015870   IPI01015912   IPI01013638   
Protein Interaction databases
DIP (DOE-UCLA)P07864
IntAct (EBI)P07864
FunCoupENSG00000166796
BioGRIDLDHC
STRING (EMBL)LDHC
ZODIACLDHC
Ontologies - Pathways
QuickGOP07864
Ontology : AmiGOL-lactate dehydrogenase activity  nucleus  cytosol  carbohydrate metabolic process  pyruvate metabolic process  ATP biosynthetic process  lactate biosynthetic process from pyruvate  lactate oxidation  flagellated sperm motility  motile cilium  extracellular exosome  
Ontology : EGO-EBIL-lactate dehydrogenase activity  nucleus  cytosol  carbohydrate metabolic process  pyruvate metabolic process  ATP biosynthetic process  lactate biosynthetic process from pyruvate  lactate oxidation  flagellated sperm motility  motile cilium  extracellular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Cysteine and methionine metabolism    Pyruvate metabolism    Propanoate metabolism   
NDEx NetworkLDHC
Atlas of Cancer Signalling NetworkLDHC
Wikipedia pathwaysLDHC
Orthology - Evolution
OrthoDB3948
GeneTree (enSembl)ENSG00000166796
Phylogenetic Trees/Animal Genes : TreeFamLDHC
HOVERGENP07864
HOGENOMP07864
Homologs : HomoloGeneLDHC
Homology/Alignments : Family Browser (UCSC)LDHC
Gene fusions - Rearrangements
Fusion : MitelmanLDHC/SERGEF [11p15.1/11p15.1]  
Fusion : QuiverLDHC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLDHC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LDHC
dbVarLDHC
ClinVarLDHC
1000_GenomesLDHC 
Exome Variant ServerLDHC
ExAC (Exome Aggregation Consortium)ENSG00000166796
GNOMAD BrowserENSG00000166796
Varsome BrowserLDHC
Genetic variants : HAPMAP3948
Genomic Variants (DGV)LDHC [DGVbeta]
DECIPHERLDHC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLDHC 
Mutations
ICGC Data PortalLDHC 
TCGA Data PortalLDHC 
Broad Tumor PortalLDHC
OASIS PortalLDHC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLDHC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLDHC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LDHC
DgiDB (Drug Gene Interaction Database)LDHC
DoCM (Curated mutations)LDHC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LDHC (select a term)
intoGenLDHC
Cancer3DLDHC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150150   
Orphanet
DisGeNETLDHC
MedgenLDHC
Genetic Testing Registry LDHC
NextProtP07864 [Medical]
TSGene3948
GENETestsLDHC
Target ValidationLDHC
Huge Navigator LDHC [HugePedia]
snp3D : Map Gene to Disease3948
BioCentury BCIQLDHC
ClinGenLDHC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3948
Chemical/Pharm GKB GenePA30328
Clinical trialLDHC
Miscellaneous
canSAR (ICR)LDHC (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLDHC
EVEXLDHC
GoPubMedLDHC
iHOPLDHC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:16:07 CET 2018

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