Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 116842
MIM: 611373
HGNC: 29571
Ensembl: ENSG00000164406
Variants:
dbSNP: 116842
ClinVar: 116842
TCGA: ENSG00000164406
COSMIC: LEAP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164406 | ENST00000296877 | Q969E1 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Antimicrobial peptides | REACTOME | R-HSA-6803157 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37436962 | 2023 | LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes. | 1 |
| 37436962 | 2023 | LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes. | 1 |
| 36076912 | 2022 | Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy. | 4 |
| 36076912 | 2022 | Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy. | 4 |
| 33139887 | 2021 | Circulating LEAP-2 is associated with puberty in girls. | 13 |
| 33811478 | 2021 | Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis. | 4 |
| 33966114 | 2021 | LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish. | 6 |
| 33991145 | 2021 | LEAP-2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study. | 5 |
| 33139887 | 2021 | Circulating LEAP-2 is associated with puberty in girls. | 13 |
| 33811478 | 2021 | Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis. | 4 |
| 33966114 | 2021 | LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish. | 6 |
| 33991145 | 2021 | LEAP-2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study. | 5 |
| 31526069 | 2020 | Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome. | 5 |
| 31770106 | 2020 | Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance. | 20 |
| 32268520 | 2020 | Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis. | 10 |
Citation
Dessen P
LEAP2 (liver enriched antimicrobial peptide 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-03-01
Online version: http://atlasgeneticsoncology.org/gene/51383/leap2
