LECT2 (leukocyte cell derived chemotaxin 2)

2011-11-01  

Identity

HGNC
LECT2
LOCATION
5q31.1
LOCUSID
3950
ALIAS
chm-II,chm2

Other Information

Locus ID:

NCBI: 3950
MIM: 602882
HGNC: 6550
Ensembl: ENSG00000145826

Variants:

dbSNP: 3950
ClinVar: 3950
TCGA: ENSG00000145826
COSMIC: LECT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145826ENST00000274507O14960
ENSG00000145826ENST00000512872D6RD58
ENSG00000145826ENST00000514447D6RGX8
ENSG00000145826ENST00000522943E5RHW6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
152391002004Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
244783972014LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance.25
209514862010Leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis: a case series.13
243903662013Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver.13
213941082011The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target.12
155612492004Serum LECT2 level as a prognostic indicator in acute liver failure.11
241149412014Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment.11
244513242014Characterization and outcomes of renal leukocyte chemotactic factor 2-associated amyloidosis.11

Citation

Dessen P

LECT2 (leukocyte cell derived chemotaxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52494/lect2