Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LEF1 (lymphoid enhancer binding factor 1)

Identity

Alias_nameslymphoid enhancer-binding factor 1
Alias_symbol (synonym)TCF1ALPHA
TCF10
TCF7L3
Other aliasLEF-1
HGNC (Hugo) LEF1
LocusID (NCBI) 51176
Atlas_Id 401
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 108968701 and ends at 109090112 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EFHD1 (2q37.1) / LEF1 (4q25)LEF1 (4q25) / HADH (4q25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Skin: Pilomatricoma


External links

Nomenclature
HGNC (Hugo)LEF1   6551
Cards
Entrez_Gene (NCBI)LEF1  51176  lymphoid enhancer binding factor 1
AliasesLEF-1; TCF10; TCF1ALPHA; TCF7L3
GeneCards (Weizmann)LEF1
Ensembl hg19 (Hinxton)ENSG00000138795 [Gene_View]  chr4:108968701-109090112 [Contig_View]  LEF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138795 [Gene_View]  chr4:108968701-109090112 [Contig_View]  LEF1 [Vega]
ICGC DataPortalENSG00000138795
TCGA cBioPortalLEF1
AceView (NCBI)LEF1
Genatlas (Paris)LEF1
WikiGenes51176
SOURCE (Princeton)LEF1
Genetics Home Reference (NIH)LEF1
Genomic and cartography
GoldenPath hg19 (UCSC)LEF1  -     chr4:108968701-109090112 -  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEF1  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblLEF1 - 4q25 [CytoView hg19]  LEF1 - 4q25 [CytoView hg38]
Mapping of homologs : NCBILEF1 [Mapview hg19]  LEF1 [Mapview hg38]
OMIM153245   
Gene and transcription
Genbank (Entrez)AF086339 AF198532 AF288571 AF294627 AK128255
RefSeq transcript (Entrez)NM_001130713 NM_001130714 NM_001166119 NM_016269
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_015798 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)LEF1
Cluster EST : UnigeneHs.743478 [ NCBI ]
CGAP (NCI)Hs.743478
Alternative Splicing GalleryENSG00000138795
Gene ExpressionLEF1 [ NCBI-GEO ]   LEF1 [ EBI - ARRAY_EXPRESS ]   LEF1 [ SEEK ]   LEF1 [ MEM ]
Gene Expression Viewer (FireBrowse)LEF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51176
GTEX Portal (Tissue expression)LEF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJU2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJU2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJU2
Splice isoforms : SwissVarQ9UJU2
PhosPhoSitePlusQ9UJU2
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)Catenin_binding_dom    CTNNB1-bd_N    HMG_box_dom    TCF/LEF   
Domain families : Pfam (Sanger)CTNNB1_binding (PF08347)    HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam08347    pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)LEF1
DMDM Disease mutations51176
Blocks (Seattle)LEF1
SuperfamilyQ9UJU2
Human Protein AtlasENSG00000138795
Peptide AtlasQ9UJU2
HPRD01075
IPIIPI00007156   IPI00220455   IPI00220456   IPI00220457   IPI00909155   IPI00651680   IPI00946679   IPI00965245   IPI00967606   IPI00963835   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJU2
IntAct (EBI)Q9UJU2
FunCoupENSG00000138795
BioGRIDLEF1
STRING (EMBL)LEF1
ZODIACLEF1
Ontologies - Pathways
QuickGOQ9UJU2
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  patterning of blood vessels  osteoblast differentiation  neural crest cell migration  somitogenesis  kidney development  epithelial to mesenchymal transition  sprouting angiogenesis  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleus  nucleoplasm  transcription factor complex  cytoplasm  transcription from RNA polymerase II promoter  Wnt signaling pathway, calcium modulating pathway  beta-catenin binding  beta-catenin binding  beta-catenin binding  transcription factor binding  positive regulation of cell proliferation  DNA binding, bending  response to lithium ion  positive regulation of gene expression  positive regulation of epithelial to mesenchymal transition  Wnt signaling pathway  regulation of striated muscle tissue development  dentate gyrus development  hypothalamus development  forebrain radial glial cell differentiation  forebrain neuroblast division  forebrain neuron differentiation  formation of radial glial scaffolds  regulation of cell-cell adhesion  negative regulation of cell-cell adhesion  positive regulation of cell-cell adhesion  neutrophil differentiation  estrogen receptor activity  positive regulation of cell growth  embryonic limb morphogenesis  estrogen receptor binding  positive regulation of cell migration  positive regulation of cell migration  BMP signaling pathway  positive regulation of granulocyte differentiation  positive regulation of granulocyte differentiation  mammary gland development  organ regeneration  negative regulation of interleukin-13 production  negative regulation of interleukin-4 production  negative regulation of interleukin-5 production  protein-DNA complex  T cell receptor V(D)J recombination  enhancer binding  B cell proliferation  histone binding  odontogenesis of dentin-containing tooth  histone deacetylase binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of DNA binding  steroid hormone mediated signaling pathway  sequence-specific DNA binding  tongue development  skin development  positive regulation by host of viral transcription  histone H3 acetylation  histone H4 acetylation  transcription regulatory region DNA binding  transcription regulatory region DNA binding  T-helper 1 cell differentiation  gamma-catenin binding  negative regulation of striated muscle tissue development  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  alpha-beta T cell differentiation  eye pigmentation  paraxial mesoderm formation  muscle fiber development  sensory perception of taste  palate development  anatomical structure regression  canonical Wnt signaling pathway  canonical Wnt signaling pathway  face morphogenesis  cell chemotaxis  apoptotic process involved in morphogenesis  chorio-allantoic fusion  trachea gland development  armadillo repeat domain binding  C2H2 zinc finger domain binding  cellular response to cytokine stimulus  cellular response to interleukin-4  positive regulation of cell proliferation in bone marrow  negative regulation of apoptotic process in bone marrow  odontoblast differentiation  negative regulation of estrogen receptor binding  positive regulation of cell cycle process  negative regulation of canonical Wnt signaling pathway  apoptotic process involved in patterning of blood vessels  beta-catenin-TCF complex assembly  beta-catenin-TCF complex  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  patterning of blood vessels  osteoblast differentiation  neural crest cell migration  somitogenesis  kidney development  epithelial to mesenchymal transition  sprouting angiogenesis  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleus  nucleoplasm  transcription factor complex  cytoplasm  transcription from RNA polymerase II promoter  Wnt signaling pathway, calcium modulating pathway  beta-catenin binding  beta-catenin binding  beta-catenin binding  transcription factor binding  positive regulation of cell proliferation  DNA binding, bending  response to lithium ion  positive regulation of gene expression  positive regulation of epithelial to mesenchymal transition  Wnt signaling pathway  regulation of striated muscle tissue development  dentate gyrus development  hypothalamus development  forebrain radial glial cell differentiation  forebrain neuroblast division  forebrain neuron differentiation  formation of radial glial scaffolds  regulation of cell-cell adhesion  negative regulation of cell-cell adhesion  positive regulation of cell-cell adhesion  neutrophil differentiation  estrogen receptor activity  positive regulation of cell growth  embryonic limb morphogenesis  estrogen receptor binding  positive regulation of cell migration  positive regulation of cell migration  BMP signaling pathway  positive regulation of granulocyte differentiation  positive regulation of granulocyte differentiation  mammary gland development  organ regeneration  negative regulation of interleukin-13 production  negative regulation of interleukin-4 production  negative regulation of interleukin-5 production  protein-DNA complex  T cell receptor V(D)J recombination  enhancer binding  B cell proliferation  histone binding  odontogenesis of dentin-containing tooth  histone deacetylase binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of DNA binding  steroid hormone mediated signaling pathway  sequence-specific DNA binding  tongue development  skin development  positive regulation by host of viral transcription  histone H3 acetylation  histone H4 acetylation  transcription regulatory region DNA binding  transcription regulatory region DNA binding  T-helper 1 cell differentiation  gamma-catenin binding  negative regulation of striated muscle tissue development  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  alpha-beta T cell differentiation  eye pigmentation  paraxial mesoderm formation  muscle fiber development  sensory perception of taste  palate development  anatomical structure regression  canonical Wnt signaling pathway  canonical Wnt signaling pathway  face morphogenesis  cell chemotaxis  apoptotic process involved in morphogenesis  chorio-allantoic fusion  trachea gland development  armadillo repeat domain binding  C2H2 zinc finger domain binding  cellular response to cytokine stimulus  cellular response to interleukin-4  positive regulation of cell proliferation in bone marrow  negative regulation of apoptotic process in bone marrow  odontoblast differentiation  negative regulation of estrogen receptor binding  positive regulation of cell cycle process  negative regulation of canonical Wnt signaling pathway  apoptotic process involved in patterning of blood vessels  beta-catenin-TCF complex assembly  beta-catenin-TCF complex  
Pathways : BIOCARTAInactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Multi-step Regulation of Transcription by Pitx2 [Genes]   
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Adherens junction    Melanogenesis    Pathways in cancer    Colorectal cancer    Endometrial cancer    Prostate cancer    Thyroid cancer    Basal cell carcinoma    Acute myeloid leukemia    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkLEF1
Atlas of Cancer Signalling NetworkLEF1
Wikipedia pathwaysLEF1
Orthology - Evolution
OrthoDB51176
GeneTree (enSembl)ENSG00000138795
Phylogenetic Trees/Animal Genes : TreeFamLEF1
HOVERGENQ9UJU2
HOGENOMQ9UJU2
Homologs : HomoloGeneLEF1
Homology/Alignments : Family Browser (UCSC)LEF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEF1
dbVarLEF1
ClinVarLEF1
1000_GenomesLEF1 
Exome Variant ServerLEF1
ExAC (Exome Aggregation Consortium)LEF1 (select the gene name)
Genetic variants : HAPMAP51176
Genomic Variants (DGV)LEF1 [DGVbeta]
DECIPHER (Syndromes)4:108968701-109090112  ENSG00000138795
CONAN: Copy Number AnalysisLEF1 
Mutations
ICGC Data PortalLEF1 
TCGA Data PortalLEF1 
Broad Tumor PortalLEF1
OASIS PortalLEF1 [ Somatic mutations - Copy number]
Cancer Gene: CensusLEF1 
Somatic Mutations in Cancer : COSMICLEF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLEF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEF1
DgiDB (Drug Gene Interaction Database)LEF1
DoCM (Curated mutations)LEF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEF1 (select a term)
intoGenLEF1
Cancer3DLEF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153245   
Orphanet
MedgenLEF1
Genetic Testing Registry LEF1
NextProtQ9UJU2 [Medical]
TSGene51176
GENETestsLEF1
Huge Navigator LEF1 [HugePedia]
snp3D : Map Gene to Disease51176
BioCentury BCIQLEF1
ClinGenLEF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51176
Chemical/Pharm GKB GenePA30331
Clinical trialLEF1
Miscellaneous
canSAR (ICR)LEF1 (select the gene name)
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEF1
EVEXLEF1
GoPubMedLEF1
iHOPLEF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:12:39 CET 2017

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