LEFTY2 (left-right determination factor 2)

2003-12-01  

Identity

HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
EBAF,LEFTA,LEFTYA,TGFB4
FUSION GENES

Other Information

Locus ID:

NCBI: 7044
MIM: 601877
HGNC: 3122
Ensembl: ENSG00000143768

Variants:

dbSNP: 7044
ClinVar: 7044
TCGA: ENSG00000143768
COSMIC: LEFTY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143768ENST00000366820O00292
ENSG00000143768ENST00000366820A0A024R3P5
ENSG00000143768ENST00000420304O00292

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153086652004Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.62
212665362011The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.43
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
122154262002Regulation and function of LEFTY-A/EBAF in the human endometrium. mRNA expression during the menstrual cycle, control by progesterone, and effect on matrix metalloprotineases.14
170386732007Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.13
224699822013Role of Lefty in the anti tumor activity of human adult liver stem cells.12
274976692016LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a.8
155361552005Regulation of matrix metalloproteinase-9/gelatinase B expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium.7
305757242018Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty.7

Citation

Dessen P

LEFTY2 (left-right determination factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40392/lefty2