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LEFTY2 (left-right determination factor 2)

Identity

Alias (NCBI)EBAF
LEFTA
LEFTYA
TGFB4
HGNC (Hugo) LEFTY2
HGNC Alias symbLEFTA
LEFTYA
HGNC Alias nametransforming growth factor, beta-4 (endometrial bleeding-associated factor; LEFTY A)
HGNC Previous nameTGFB4
 EBAF
HGNC Previous nameendometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily)
LocusID (NCBI) 7044
Atlas_Id 40392
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 225936603 and ends at 225941220 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SRGAP1 (12q14.2) / LEFTY2 (1q42.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LEFTY2   3122
Cards
Entrez_Gene (NCBI)LEFTY2    left-right determination factor 2
AliasesEBAF; LEFTA; LEFTYA; TGFB4
GeneCards (Weizmann)LEFTY2
Ensembl hg19 (Hinxton)ENSG00000143768 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143768 [Gene_View]  ENSG00000143768 [Sequence]  chr1:225936603-225941220 [Contig_View]  LEFTY2 [Vega]
ICGC DataPortalENSG00000143768
TCGA cBioPortalLEFTY2
AceView (NCBI)LEFTY2
Genatlas (Paris)LEFTY2
SOURCE (Princeton)LEFTY2
Genetics Home Reference (NIH)LEFTY2
Genomic and cartography
GoldenPath hg38 (UCSC)LEFTY2  -     chr1:225936603-225941220 -  1q42.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LEFTY2  -     1q42.12   [Description]    (hg19-Feb_2009)
GoldenPathLEFTY2 - 1q42.12 [CytoView hg19]  LEFTY2 - 1q42.12 [CytoView hg38]
ImmunoBaseENSG00000143768
Genome Data Viewer NCBILEFTY2 [Mapview hg19]  
OMIM601877   
Gene and transcription
Genbank (Entrez)AA922485 AF081513 AK027520 AK075344 AK094077
RefSeq transcript (Entrez)NM_001172425 NM_003240
Consensus coding sequences : CCDS (NCBI)LEFTY2
Gene ExpressionLEFTY2 [ NCBI-GEO ]   LEFTY2 [ EBI - ARRAY_EXPRESS ]   LEFTY2 [ SEEK ]   LEFTY2 [ MEM ]
Gene Expression Viewer (FireBrowse)LEFTY2 [ Firebrowse - Broad ]
GenevisibleExpression of LEFTY2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7044
GTEX Portal (Tissue expression)LEFTY2
Human Protein AtlasENSG00000143768-LEFTY2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00292   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00292  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00292
PhosPhoSitePlusO00292
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    LRDF    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)LEFTY2
SuperfamilyO00292
AlphaFold pdb e-kbO00292   
Human Protein Atlas [tissue]ENSG00000143768-LEFTY2 [tissue]
HPRD03526
Protein Interaction databases
DIP (DOE-UCLA)O00292
IntAct (EBI)O00292
BioGRIDLEFTY2
STRING (EMBL)LEFTY2
ZODIACLEFTY2
Ontologies - Pathways
QuickGOO00292
Ontology : AmiGOplatelet degranulation  cytokine activity  transforming growth factor beta receptor binding  extracellular region  extracellular space  transforming growth factor beta receptor signaling pathway  multicellular organism development  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  platelet alpha granule lumen  SMAD protein signal transduction  collagen-containing extracellular matrix  
Ontology : EGO-EBIplatelet degranulation  cytokine activity  transforming growth factor beta receptor binding  extracellular region  extracellular space  transforming growth factor beta receptor signaling pathway  multicellular organism development  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  platelet alpha granule lumen  SMAD protein signal transduction  collagen-containing extracellular matrix  
Pathways : KEGGTGF-beta signaling pathway   
NDEx NetworkLEFTY2
Atlas of Cancer Signalling NetworkLEFTY2
Wikipedia pathwaysLEFTY2
Orthology - Evolution
OrthoDB7044
GeneTree (enSembl)ENSG00000143768
Phylogenetic Trees/Animal Genes : TreeFamLEFTY2
Homologs : HomoloGeneLEFTY2
Homology/Alignments : Family Browser (UCSC)LEFTY2
Gene fusions - Rearrangements
Fusion : QuiverLEFTY2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEFTY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEFTY2
dbVarLEFTY2
ClinVarLEFTY2
MonarchLEFTY2
1000_GenomesLEFTY2 
Exome Variant ServerLEFTY2
GNOMAD BrowserENSG00000143768
Varsome BrowserLEFTY2
ACMGLEFTY2 variants
VarityO00292
Genomic Variants (DGV)LEFTY2 [DGVbeta]
DECIPHERLEFTY2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLEFTY2 
Mutations
ICGC Data PortalLEFTY2 
TCGA Data PortalLEFTY2 
Broad Tumor PortalLEFTY2
OASIS PortalLEFTY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEFTY2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLEFTY2
Mutations and Diseases : HGMDLEFTY2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLEFTY2
DgiDB (Drug Gene Interaction Database)LEFTY2
DoCM (Curated mutations)LEFTY2
CIViC (Clinical Interpretations of Variants in Cancer)LEFTY2
Cancer3DLEFTY2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601877   
Orphanet17142   
DisGeNETLEFTY2
MedgenLEFTY2
Genetic Testing Registry LEFTY2
NextProtO00292 [Medical]
GENETestsLEFTY2
Target ValidationLEFTY2
Huge Navigator LEFTY2 [HugePedia]
ClinGenLEFTY2
Clinical trials, drugs, therapy
MyCancerGenomeLEFTY2
Protein Interactions : CTDLEFTY2
Pharm GKB GenePA27580
PharosO00292
Clinical trialLEFTY2
Miscellaneous
canSAR (ICR)LEFTY2
HarmonizomeLEFTY2
DataMed IndexLEFTY2
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLEFTY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:45 CEST 2021

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