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LEFTY2 (left-right determination factor 2)

Identity

Alias_namesbeta-4 (endometrial bleeding-associated factor
LEFTY A)
Alias_symbol (synonym)LEFTA
LEFTYA
Other aliasEBAF
TGFB4
HGNC (Hugo) LEFTY2
LocusID (NCBI) 7044
Atlas_Id 40392
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 226124298 and ends at 226129083 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SRGAP1 (12q14.2) / LEFTY2 (1q42.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LEFTY2   3122
Cards
Entrez_Gene (NCBI)LEFTY2  7044  left-right determination factor 2
AliasesEBAF; LEFTA; LEFTYA; TGFB4
GeneCards (Weizmann)LEFTY2
Ensembl hg19 (Hinxton)ENSG00000143768 [Gene_View]  chr1:226124298-226129083 [Contig_View]  LEFTY2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143768 [Gene_View]  chr1:226124298-226129083 [Contig_View]  LEFTY2 [Vega]
ICGC DataPortalENSG00000143768
TCGA cBioPortalLEFTY2
AceView (NCBI)LEFTY2
Genatlas (Paris)LEFTY2
WikiGenes7044
SOURCE (Princeton)LEFTY2
Genetics Home Reference (NIH)LEFTY2
Genomic and cartography
GoldenPath hg19 (UCSC)LEFTY2  -     chr1:226124298-226129083 -  1q42.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEFTY2  -     1q42.12   [Description]    (hg38-Dec_2013)
EnsemblLEFTY2 - 1q42.12 [CytoView hg19]  LEFTY2 - 1q42.12 [CytoView hg38]
Mapping of homologs : NCBILEFTY2 [Mapview hg19]  LEFTY2 [Mapview hg38]
OMIM601877   
Gene and transcription
Genbank (Entrez)AA922485 AF081513 AK027520 AK075344 AK094077
RefSeq transcript (Entrez)NM_001172425 NM_003240
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008118 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)LEFTY2
Cluster EST : UnigeneHs.520187 [ NCBI ]
CGAP (NCI)Hs.520187
Alternative Splicing GalleryENSG00000143768
Gene ExpressionLEFTY2 [ NCBI-GEO ]   LEFTY2 [ EBI - ARRAY_EXPRESS ]   LEFTY2 [ SEEK ]   LEFTY2 [ MEM ]
Gene Expression Viewer (FireBrowse)LEFTY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7044
GTEX Portal (Tissue expression)LEFTY2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00292   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00292  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00292
Splice isoforms : SwissVarO00292
PhosPhoSitePlusO00292
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    LRDF    TGF-b_C    TGF-b_N    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)LEFTY2
DMDM Disease mutations7044
Blocks (Seattle)LEFTY2
SuperfamilyO00292
Human Protein AtlasENSG00000143768
Peptide AtlasO00292
HPRD03526
IPIIPI00010893   IPI00910132   
Protein Interaction databases
DIP (DOE-UCLA)O00292
IntAct (EBI)O00292
FunCoupENSG00000143768
BioGRIDLEFTY2
STRING (EMBL)LEFTY2
ZODIACLEFTY2
Ontologies - Pathways
QuickGOO00292
Ontology : AmiGOplatelet degranulation  cytokine activity  transforming growth factor beta receptor binding  extracellular region  extracellular space  transforming growth factor beta receptor signaling pathway  multicellular organism development  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  cell growth  extracellular matrix  platelet alpha granule lumen  regulation of apoptotic process  regulation of MAPK cascade  cell development  SMAD protein signal transduction  
Ontology : EGO-EBIplatelet degranulation  cytokine activity  transforming growth factor beta receptor binding  extracellular region  extracellular space  transforming growth factor beta receptor signaling pathway  multicellular organism development  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  cell growth  extracellular matrix  platelet alpha granule lumen  regulation of apoptotic process  regulation of MAPK cascade  cell development  SMAD protein signal transduction  
Pathways : KEGGTGF-beta signaling pathway   
NDEx NetworkLEFTY2
Atlas of Cancer Signalling NetworkLEFTY2
Wikipedia pathwaysLEFTY2
Orthology - Evolution
OrthoDB7044
GeneTree (enSembl)ENSG00000143768
Phylogenetic Trees/Animal Genes : TreeFamLEFTY2
HOVERGENO00292
HOGENOMO00292
Homologs : HomoloGeneLEFTY2
Homology/Alignments : Family Browser (UCSC)LEFTY2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEFTY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEFTY2
dbVarLEFTY2
ClinVarLEFTY2
1000_GenomesLEFTY2 
Exome Variant ServerLEFTY2
ExAC (Exome Aggregation Consortium)LEFTY2 (select the gene name)
Genetic variants : HAPMAP7044
Genomic Variants (DGV)LEFTY2 [DGVbeta]
DECIPHER (Syndromes)1:226124298-226129083  ENSG00000143768
CONAN: Copy Number AnalysisLEFTY2 
Mutations
ICGC Data PortalLEFTY2 
TCGA Data PortalLEFTY2 
Broad Tumor PortalLEFTY2
OASIS PortalLEFTY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEFTY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLEFTY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEFTY2
DgiDB (Drug Gene Interaction Database)LEFTY2
DoCM (Curated mutations)LEFTY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEFTY2 (select a term)
intoGenLEFTY2
Cancer3DLEFTY2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601877   
Orphanet17142   
MedgenLEFTY2
Genetic Testing Registry LEFTY2
NextProtO00292 [Medical]
TSGene7044
GENETestsLEFTY2
Huge Navigator LEFTY2 [HugePedia]
snp3D : Map Gene to Disease7044
BioCentury BCIQLEFTY2
ClinGenLEFTY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7044
Chemical/Pharm GKB GenePA27580
Clinical trialLEFTY2
Miscellaneous
canSAR (ICR)LEFTY2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEFTY2
EVEXLEFTY2
GoPubMedLEFTY2
iHOPLEFTY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:39 CET 2017

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