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LEMD2 (LEM domain containing 2)

Identity

Alias_symbol (synonym)dJ482C21.1
NET25
Other aliasCTRCT42
HGNC (Hugo) LEMD2
LocusID (NCBI) 221496
Atlas_Id 54422
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 33771213 and ends at 33786942 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYP39A1 (6p12.3) / LEMD2 (6p21.31)FUT9 (6q16.1) / LEMD2 (6p21.31)LEMD2 (6p21.31) / LEMD2 (6p21.31)
LEMD2 (6p21.31) / MALAT1 (11q13.1)PRKCB (16p12.2) / LEMD2 (6p21.31)CYP39A1 6p12.3 / LEMD2 6p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LEMD2   21244
Cards
Entrez_Gene (NCBI)LEMD2  221496  LEM domain containing 2
AliasesCTRCT42; NET25; dJ482C21.1
GeneCards (Weizmann)LEMD2
Ensembl hg19 (Hinxton)ENSG00000161904 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161904 [Gene_View]  chr6:33771213-33786942 [Contig_View]  LEMD2 [Vega]
ICGC DataPortalENSG00000161904
TCGA cBioPortalLEMD2
AceView (NCBI)LEMD2
Genatlas (Paris)LEMD2
WikiGenes221496
SOURCE (Princeton)LEMD2
Genetics Home Reference (NIH)LEMD2
Genomic and cartography
GoldenPath hg38 (UCSC)LEMD2  -     chr6:33771213-33786942 -  6p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LEMD2  -     6p21.31   [Description]    (hg19-Feb_2009)
EnsemblLEMD2 - 6p21.31 [CytoView hg19]  LEMD2 - 6p21.31 [CytoView hg38]
Mapping of homologs : NCBILEMD2 [Mapview hg19]  LEMD2 [Mapview hg38]
OMIM212500   616312   
Gene and transcription
Genbank (Entrez)AK024858 AK026077 AK074959 AK127084 AK301083
RefSeq transcript (Entrez)NM_001143944 NM_001348709 NM_001348710 NM_181336
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LEMD2
Cluster EST : UnigeneHs.444845 [ NCBI ]
CGAP (NCI)Hs.444845
Alternative Splicing GalleryENSG00000161904
Gene ExpressionLEMD2 [ NCBI-GEO ]   LEMD2 [ EBI - ARRAY_EXPRESS ]   LEMD2 [ SEEK ]   LEMD2 [ MEM ]
Gene Expression Viewer (FireBrowse)LEMD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221496
GTEX Portal (Tissue expression)LEMD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NC56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NC56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NC56
Splice isoforms : SwissVarQ8NC56
PhosPhoSitePlusQ8NC56
Domaine pattern : Prosite (Expaxy)LEM (PS50954)   
Domains : Interpro (EBI)Inner-Nucl-membr_MAN1    LEM/LEM-like_dom    LEM_dom   
Domain families : Pfam (Sanger)LEM (PF03020)    MSC (PF09402)   
Domain families : Pfam (NCBI)pfam03020    pfam09402   
Domain families : Smart (EMBL)LEM (SM00540)  
Conserved Domain (NCBI)LEMD2
DMDM Disease mutations221496
Blocks (Seattle)LEMD2
SuperfamilyQ8NC56
Human Protein AtlasENSG00000161904
Peptide AtlasQ8NC56
HPRD13984
IPIIPI00168336   IPI00514106   IPI00964346   IPI00941685   IPI00966169   IPI00964438   IPI00967133   
Protein Interaction databases
DIP (DOE-UCLA)Q8NC56
IntAct (EBI)Q8NC56
FunCoupENSG00000161904
BioGRIDLEMD2
STRING (EMBL)LEMD2
ZODIACLEMD2
Ontologies - Pathways
QuickGOQ8NC56
Ontology : AmiGOintegral component of nuclear inner membrane  nuclear envelope organization  membrane  neurogenesis  negative regulation of BMP signaling pathway  chromatin DNA binding  nuclear membrane  skeletal muscle cell differentiation  negative regulation of MAPK cascade  negative regulation of protein kinase B signaling  heart formation  meiotic attachment of telomere to nuclear envelope  
Ontology : EGO-EBIintegral component of nuclear inner membrane  nuclear envelope organization  membrane  neurogenesis  negative regulation of BMP signaling pathway  chromatin DNA binding  nuclear membrane  skeletal muscle cell differentiation  negative regulation of MAPK cascade  negative regulation of protein kinase B signaling  heart formation  meiotic attachment of telomere to nuclear envelope  
NDEx NetworkLEMD2
Atlas of Cancer Signalling NetworkLEMD2
Wikipedia pathwaysLEMD2
Orthology - Evolution
OrthoDB221496
GeneTree (enSembl)ENSG00000161904
Phylogenetic Trees/Animal Genes : TreeFamLEMD2
HOVERGENQ8NC56
HOGENOMQ8NC56
Homologs : HomoloGeneLEMD2
Homology/Alignments : Family Browser (UCSC)LEMD2
Gene fusions - Rearrangements
Fusion : MitelmanCYP39A1/LEMD2 [6p12.3/6p21.31]  [t(6;6)(p12;p21)]  
Fusion: TCGACYP39A1 6p12.3 LEMD2 6p21.31 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEMD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEMD2
dbVarLEMD2
ClinVarLEMD2
1000_GenomesLEMD2 
Exome Variant ServerLEMD2
ExAC (Exome Aggregation Consortium)LEMD2 (select the gene name)
Genetic variants : HAPMAP221496
Genomic Variants (DGV)LEMD2 [DGVbeta]
DECIPHERLEMD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLEMD2 
Mutations
ICGC Data PortalLEMD2 
TCGA Data PortalLEMD2 
Broad Tumor PortalLEMD2
OASIS PortalLEMD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEMD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLEMD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEMD2
DgiDB (Drug Gene Interaction Database)LEMD2
DoCM (Curated mutations)LEMD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEMD2 (select a term)
intoGenLEMD2
Cancer3DLEMD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM212500    616312   
Orphanet23422    14011   
MedgenLEMD2
Genetic Testing Registry LEMD2
NextProtQ8NC56 [Medical]
TSGene221496
GENETestsLEMD2
Target ValidationLEMD2
Huge Navigator LEMD2 [HugePedia]
snp3D : Map Gene to Disease221496
BioCentury BCIQLEMD2
ClinGenLEMD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD221496
Chemical/Pharm GKB GenePA134952135
Clinical trialLEMD2
Miscellaneous
canSAR (ICR)LEMD2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEMD2
EVEXLEMD2
GoPubMedLEMD2
iHOPLEMD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:40:23 CEST 2017

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