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LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)

Identity

Alias_namesLeo1
Other aliasRDL
HGNC (Hugo) LEO1
LocusID (NCBI) 123169
Atlas_Id 54002
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 52230222 and ends at 52263998 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AIF1 (6p21.33) / LEO1 (15q21.2)IREB2 (15q25.1) / LEO1 (15q21.2)LEO1 (15q21.2) / FBN1 (15q21.1)
LEO1 (15q21.2) / LEO1 (15q21.2)LEO1 (15q21.2) / SLC12A1 (15q21.1)IREB2 15q25.1 / LEO1 15q21.2
LEO1 15q21.2 / FBN1 15q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LEO1   30401
Cards
Entrez_Gene (NCBI)LEO1  123169  LEO1 homolog, Paf1/RNA polymerase II complex component
AliasesRDL
GeneCards (Weizmann)LEO1
Ensembl hg19 (Hinxton)ENSG00000166477 [Gene_View]  chr15:52230222-52263998 [Contig_View]  LEO1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166477 [Gene_View]  chr15:52230222-52263998 [Contig_View]  LEO1 [Vega]
ICGC DataPortalENSG00000166477
TCGA cBioPortalLEO1
AceView (NCBI)LEO1
Genatlas (Paris)LEO1
WikiGenes123169
SOURCE (Princeton)LEO1
Genetics Home Reference (NIH)LEO1
Genomic and cartography
GoldenPath hg19 (UCSC)LEO1  -     chr15:52230222-52263998 -  15q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEO1  -     15q21.2   [Description]    (hg38-Dec_2013)
EnsemblLEO1 - 15q21.2 [CytoView hg19]  LEO1 - 15q21.2 [CytoView hg38]
Mapping of homologs : NCBILEO1 [Mapview hg19]  LEO1 [Mapview hg38]
OMIM610507   
Gene and transcription
Genbank (Entrez)AK055762 AK297972 AY302186 BC018147
RefSeq transcript (Entrez)NM_001286430 NM_138792
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)LEO1
Cluster EST : UnigeneHs.567662 [ NCBI ]
CGAP (NCI)Hs.567662
Alternative Splicing GalleryENSG00000166477
Gene ExpressionLEO1 [ NCBI-GEO ]   LEO1 [ EBI - ARRAY_EXPRESS ]   LEO1 [ SEEK ]   LEO1 [ MEM ]
Gene Expression Viewer (FireBrowse)LEO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)123169
GTEX Portal (Tissue expression)LEO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WVC0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WVC0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WVC0
Splice isoforms : SwissVarQ8WVC0
PhosPhoSitePlusQ8WVC0
Domains : Interpro (EBI)Leo1   
Domain families : Pfam (Sanger)Leo1 (PF04004)   
Domain families : Pfam (NCBI)pfam04004   
Conserved Domain (NCBI)LEO1
DMDM Disease mutations123169
Blocks (Seattle)LEO1
PDB (SRS)4M6T   
PDB (PDBSum)4M6T   
PDB (IMB)4M6T   
PDB (RSDB)4M6T   
Structural Biology KnowledgeBase4M6T   
SCOP (Structural Classification of Proteins)4M6T   
CATH (Classification of proteins structures)4M6T   
SuperfamilyQ8WVC0
Human Protein AtlasENSG00000166477
Peptide AtlasQ8WVC0
HPRD11231
IPIIPI00103090   IPI00154162   IPI01011777   
Protein Interaction databases
DIP (DOE-UCLA)Q8WVC0
IntAct (EBI)Q8WVC0
FunCoupENSG00000166477
BioGRIDLEO1
STRING (EMBL)LEO1
ZODIACLEO1
Ontologies - Pathways
QuickGOQ8WVC0
Ontology : AmiGOendodermal cell fate commitment  protein binding  nucleoplasm  nucleoplasm  nucleolus  centrosome  transcription elongation from RNA polymerase II promoter  mRNA polyadenylation  histone monoubiquitination  Wnt signaling pathway  Cdc73/Paf1 complex  stem cell population maintenance  positive regulation of mRNA 3'-end processing  positive regulation of transcription elongation from RNA polymerase II promoter  histone H2B ubiquitination  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  beta-catenin-TCF complex assembly  RNA polymerase II C-terminal domain phosphoserine binding  
Ontology : EGO-EBIendodermal cell fate commitment  protein binding  nucleoplasm  nucleoplasm  nucleolus  centrosome  transcription elongation from RNA polymerase II promoter  mRNA polyadenylation  histone monoubiquitination  Wnt signaling pathway  Cdc73/Paf1 complex  stem cell population maintenance  positive regulation of mRNA 3'-end processing  positive regulation of transcription elongation from RNA polymerase II promoter  histone H2B ubiquitination  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  beta-catenin-TCF complex assembly  RNA polymerase II C-terminal domain phosphoserine binding  
NDEx NetworkLEO1
Atlas of Cancer Signalling NetworkLEO1
Wikipedia pathwaysLEO1
Orthology - Evolution
OrthoDB123169
GeneTree (enSembl)ENSG00000166477
Phylogenetic Trees/Animal Genes : TreeFamLEO1
HOVERGENQ8WVC0
HOGENOMQ8WVC0
Homologs : HomoloGeneLEO1
Homology/Alignments : Family Browser (UCSC)LEO1
Gene fusions - Rearrangements
Fusion : MitelmanIREB2/LEO1 [15q25.1/15q21.2]  [t(15;15)(q21;q25)]  
Fusion : MitelmanLEO1/FBN1 [15q21.2/15q21.1]  [t(15;15)(q21;q21)]  
Fusion : MitelmanLEO1/SLC12A1 [15q21.2/15q21.1]  [t(15;15)(q21;q21)]  
Fusion: TCGAIREB2 15q25.1 LEO1 15q21.2 PRAD
Fusion: TCGALEO1 15q21.2 FBN1 15q21.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEO1
dbVarLEO1
ClinVarLEO1
1000_GenomesLEO1 
Exome Variant ServerLEO1
ExAC (Exome Aggregation Consortium)LEO1 (select the gene name)
Genetic variants : HAPMAP123169
Genomic Variants (DGV)LEO1 [DGVbeta]
DECIPHER (Syndromes)15:52230222-52263998  ENSG00000166477
CONAN: Copy Number AnalysisLEO1 
Mutations
ICGC Data PortalLEO1 
TCGA Data PortalLEO1 
Broad Tumor PortalLEO1
OASIS PortalLEO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLEO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEO1
DgiDB (Drug Gene Interaction Database)LEO1
DoCM (Curated mutations)LEO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEO1 (select a term)
intoGenLEO1
Cancer3DLEO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610507   
Orphanet
MedgenLEO1
Genetic Testing Registry LEO1
NextProtQ8WVC0 [Medical]
TSGene123169
GENETestsLEO1
Huge Navigator LEO1 [HugePedia]
snp3D : Map Gene to Disease123169
BioCentury BCIQLEO1
ClinGenLEO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD123169
Chemical/Pharm GKB GenePA142671558
Clinical trialLEO1
Miscellaneous
canSAR (ICR)LEO1 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEO1
EVEXLEO1
GoPubMedLEO1
iHOPLEO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:06:54 CEST 2017

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