LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)

2014-06-01  

Identity

HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
RDL
FUSION GENES

Other Information

Locus ID:

NCBI: 123169
MIM: 610507
HGNC: 30401
Ensembl: ENSG00000166477

Variants:

dbSNP: 123169
ClinVar: 123169
TCGA: ENSG00000166477
COSMIC: LEO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166477ENST00000299601Q8WVC0
ENSG00000166477ENST00000315141Q8WVC0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240384682013Structural insights into Paf1 complex assembly and histone binding.20
201960862010Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.14
246861702014LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.13
303057222019Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.4

Citation

Dessen P

LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54002/leo1