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LEP (leptin)

Identity

Other namesLEPD
OB
OBS
HGNC (Hugo) LEP
LocusID (NCBI) 3952
Atlas_Id 46475
Location 7q32.1
Location_base_pair Starts at 127881331 and ends at 127897682 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LEP   6553
Cards
Entrez_Gene (NCBI)LEP  3952  leptin
GeneCards (Weizmann)LEP
Ensembl hg19 (Hinxton)ENSG00000174697 [Gene_View]  chr7:127881331-127897682 [Contig_View]  LEP [Vega]
Ensembl hg38 (Hinxton)ENSG00000174697 [Gene_View]  chr7:127881331-127897682 [Contig_View]  LEP [Vega]
ICGC DataPortalENSG00000174697
TCGA cBioPortalLEP
AceView (NCBI)LEP
Genatlas (Paris)LEP
WikiGenes3952
SOURCE (Princeton)LEP
Genomic and cartography
GoldenPath hg19 (UCSC)LEP  -     chr7:127881331-127897682 +  7q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEP  -     7q32.1   [Description]    (hg38-Dec_2013)
EnsemblLEP - 7q32.1 [CytoView hg19]  LEP - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBILEP [Mapview hg19]  LEP [Mapview hg38]
OMIM164160   614962   
Gene and transcription
Genbank (Entrez)AF008123 AK313553 BC060830 BC069323 BC069452
RefSeq transcript (Entrez)NM_000230
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007450 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LEP
Cluster EST : UnigeneHs.194236 [ NCBI ]
CGAP (NCI)Hs.194236
Alternative Splicing GalleryENSG00000174697
Gene ExpressionLEP [ NCBI-GEO ]   LEP [ EBI - ARRAY_EXPRESS ]   LEP [ SEEK ]   LEP [ MEM ]
Gene Expression Viewer (FireBrowse)LEP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3952
GTEX Portal (Tissue expression)LEP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41159 (Uniprot)
NextProtP41159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41159
Splice isoforms : SwissVarP41159 (Swissvar)
PhosPhoSitePlusP41159
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Leptin   
Domain families : Pfam (Sanger)Leptin (PF02024)   
Domain families : Pfam (NCBI)pfam02024   
Domain structure : Prodom (Prabi Lyon)Leptin (PD005698)   
DMDM Disease mutations3952
Blocks (Seattle)LEP
PDB (SRS)1AX8   
PDB (PDBSum)1AX8   
PDB (IMB)1AX8   
PDB (RSDB)1AX8   
Structural Biology KnowledgeBase1AX8   
SCOP (Structural Classification of Proteins)1AX8   
CATH (Classification of proteins structures)1AX8   
SuperfamilyP41159
Human Protein AtlasENSG00000174697
Peptide AtlasP41159
HPRD01249
IPIIPI00012760   
Protein Interaction databases
DIP (DOE-UCLA)P41159
IntAct (EBI)P41159
FunCoupENSG00000174697
BioGRIDLEP
STRING (EMBL)LEP
ZODIACLEP
Ontologies - Pathways
QuickGOP41159
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  angiogenesis  ovulation from ovarian follicle  response to hypoxia  positive regulation of cytokine production  placenta development  regulation of endothelial cell proliferation  response to dietary excess  cardiac muscle hypertrophy  hormone activity  extracellular region  extracellular space  cytoplasm  glucose metabolic process  regulation of gluconeogenesis  energy reserve metabolic process  glycerol biosynthetic process  lipid metabolic process  fatty acid beta-oxidation  tyrosine phosphorylation of STAT protein  female pregnancy  circadian rhythm  growth factor activity  cholesterol metabolic process  bile acid metabolic process  regulation of blood pressure  adult feeding behavior  negative regulation of autophagy  negative regulation of lipid storage  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  response to activity  sexual reproduction  central nervous system neuron development  insulin secretion  T cell differentiation  regulation of intestinal cholesterol absorption  positive regulation of TOR signaling  negative regulation of appetite  prostaglandin secretion  response to estradiol  regulation of natural killer cell activation  regulation of natural killer cell proliferation  response to insulin  response to vitamin E  leptin-mediated signaling pathway  positive regulation of luteinizing hormone secretion  positive regulation of peroxisome proliferator activated receptor signaling pathway  bone mineralization involved in bone maturation  negative regulation of appetite by leptin-mediated signaling pathway  negative regulation of appetite by leptin-mediated signaling pathway  positive regulation of T cell proliferation  regulation of natural killer cell mediated cytotoxicity  hormone metabolic process  positive regulation of tyrosine phosphorylation of Stat3 protein  glucose homeostasis  eating behavior  negative regulation of apoptotic process  positive regulation of ion transport  positive regulation of MAPK cascade  positive regulation of MAPK cascade  cellular response to leptin stimulus  response to ethanol  positive regulation of myeloid cell differentiation  regulation of angiogenesis  negative regulation of vasoconstriction  negative regulation of glucose import  positive regulation of JAK-STAT cascade  positive regulation of insulin receptor signaling pathway  regulation of bone remodeling  positive regulation of follicle-stimulating hormone secretion  positive regulation of developmental growth  regulation of insulin secretion  regulation of steroid biosynthetic process  intestinal absorption  leukocyte tethering or rolling  regulation of nitric-oxide synthase activity  peptide hormone receptor binding  regulation of cell cycle  positive regulation of protein kinase B signaling  regulation of lipoprotein lipid oxidation  adipose tissue development  negative regulation of cartilage development  negative regulation of glucagon secretion  cellular response to L-ascorbic acid  cellular response to retinoic acid  interleukin-6 secretion  interleukin-8 secretion  regulation of brown fat cell differentiation  bone growth  regulation of cytokine production involved in inflammatory response  positive regulation of p38MAPK cascade  positive regulation of fat cell apoptotic process  activation of protein kinase C activity  positive regulation of STAT protein import into nucleus  positive regulation of reactive oxygen species metabolic process  negative regulation of glutamine transport  positive regulation of hepatic stellate cell activation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  angiogenesis  ovulation from ovarian follicle  response to hypoxia  positive regulation of cytokine production  placenta development  regulation of endothelial cell proliferation  response to dietary excess  cardiac muscle hypertrophy  hormone activity  extracellular region  extracellular space  cytoplasm  glucose metabolic process  regulation of gluconeogenesis  energy reserve metabolic process  glycerol biosynthetic process  lipid metabolic process  fatty acid beta-oxidation  tyrosine phosphorylation of STAT protein  female pregnancy  circadian rhythm  growth factor activity  cholesterol metabolic process  bile acid metabolic process  regulation of blood pressure  adult feeding behavior  negative regulation of autophagy  negative regulation of lipid storage  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  response to activity  sexual reproduction  central nervous system neuron development  insulin secretion  T cell differentiation  regulation of intestinal cholesterol absorption  positive regulation of TOR signaling  negative regulation of appetite  prostaglandin secretion  response to estradiol  regulation of natural killer cell activation  regulation of natural killer cell proliferation  response to insulin  response to vitamin E  leptin-mediated signaling pathway  positive regulation of luteinizing hormone secretion  positive regulation of peroxisome proliferator activated receptor signaling pathway  bone mineralization involved in bone maturation  negative regulation of appetite by leptin-mediated signaling pathway  negative regulation of appetite by leptin-mediated signaling pathway  positive regulation of T cell proliferation  regulation of natural killer cell mediated cytotoxicity  hormone metabolic process  positive regulation of tyrosine phosphorylation of Stat3 protein  glucose homeostasis  eating behavior  negative regulation of apoptotic process  positive regulation of ion transport  positive regulation of MAPK cascade  positive regulation of MAPK cascade  cellular response to leptin stimulus  response to ethanol  positive regulation of myeloid cell differentiation  regulation of angiogenesis  negative regulation of vasoconstriction  negative regulation of glucose import  positive regulation of JAK-STAT cascade  positive regulation of insulin receptor signaling pathway  regulation of bone remodeling  positive regulation of follicle-stimulating hormone secretion  positive regulation of developmental growth  regulation of insulin secretion  regulation of steroid biosynthetic process  intestinal absorption  leukocyte tethering or rolling  regulation of nitric-oxide synthase activity  peptide hormone receptor binding  regulation of cell cycle  positive regulation of protein kinase B signaling  regulation of lipoprotein lipid oxidation  adipose tissue development  negative regulation of cartilage development  negative regulation of glucagon secretion  cellular response to L-ascorbic acid  cellular response to retinoic acid  interleukin-6 secretion  interleukin-8 secretion  regulation of brown fat cell differentiation  bone growth  regulation of cytokine production involved in inflammatory response  positive regulation of p38MAPK cascade  positive regulation of fat cell apoptotic process  activation of protein kinase C activity  positive regulation of STAT protein import into nucleus  positive regulation of reactive oxygen species metabolic process  negative regulation of glutamine transport  positive regulation of hepatic stellate cell activation  
Pathways : BIOCARTAReversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    Jak-STAT signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)   
NDEx Network
Atlas of Cancer Signalling NetworkLEP
Wikipedia pathwaysLEP
Orthology - Evolution
OrthoDB3952
GeneTree (enSembl)ENSG00000174697
Phylogenetic Trees/Animal Genes : TreeFamLEP
Homologs : HomoloGeneLEP
Homology/Alignments : Family Browser (UCSC)LEP
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEP
dbVarLEP
ClinVarLEP
1000_GenomesLEP 
Exome Variant ServerLEP
ExAC (Exome Aggregation Consortium)LEP (select the gene name)
Genetic variants : HAPMAP3952
Genomic Variants (DGV)LEP [DGVbeta]
Mutations
ICGC Data PortalLEP 
TCGA Data PortalLEP 
Broad Tumor PortalLEP
OASIS PortalLEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEP 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEP
DgiDB (Drug Gene Interaction Database)LEP
DoCM (Curated mutations)LEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEP (select a term)
intoGenLEP
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:127881331-127897682  ENSG00000174697
CONAN: Copy Number AnalysisLEP 
Mutations and Diseases : HGMDLEP
OMIM164160    614962   
MedgenLEP
Genetic Testing Registry LEP
NextProtP41159 [Medical]
TSGene3952
GENETestsLEP
Huge Navigator LEP [HugePedia]
snp3D : Map Gene to Disease3952
BioCentury BCIQLEP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3952
Chemical/Pharm GKB GenePA228
Clinical trialLEP
Miscellaneous
canSAR (ICR)LEP (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEP
EVEXLEP
GoPubMedLEP
iHOPLEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun May 8 18:52:38 CEST 2016

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