LEP (leptin)

2007-02-01  

Identity

HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
LEPD,OB,OBS

Other Information

Locus ID:

NCBI: 3952
MIM: 164160
HGNC: 6553
Ensembl: ENSG00000174697

Variants:

dbSNP: 3952
ClinVar: 3952
TCGA: ENSG00000174697
COSMIC: LEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174697ENST00000308868P41159
ENSG00000174697ENST00000308868A4D0Y8

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Neuroactive ligand-receptor interactionKEGGko04080
Jak-STAT signaling pathwayKEGGko04630
Adipocytokine signaling pathwayKEGGko04920
Cytokine-cytokine receptor interactionKEGGhsa04060
Neuroactive ligand-receptor interactionKEGGhsa04080
Jak-STAT signaling pathwayKEGGhsa04630
Adipocytokine signaling pathwayKEGGhsa04920
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA153906318Autism Spectrum DisorderDiseaseClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915
PA447209Mood DisordersDiseaseClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD18681781
PA450688olanzapineChemicalClinicalAnnotationassociatedPD18681781
PA451257risperidoneChemicalClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915

References

Pubmed IDYearTitleCitations
123938452002Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.350
196567762009DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.337
152326122004Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.198
176902622007Leptin regulates striatal regions and human eating behavior.168
152405182004Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer.142
185680782008Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.138
171223582006Genetics of obesity in humans.134
127279332003The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.129
165337672006Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli.120
145143482003Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance.106

Citation

Dessen P

LEP (leptin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46475/lep