LEP (leptin (obesity homolog, mouse))

Identity

Other names	OB
	OBS
Hugo	LEP
Location	7q31.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	LEP
GDB	LEP
Entrez_Gene	LEP  3952  leptin (obesity homolog, mouse)
	Cards
GeneCards	LEP
Ensembl	LEP [Search_View]   ENSG00000174697 [Gene_View]
Genatlas	LEP
GeneLynx	LEP
eGenome	LEP
euGene	3952
	Genomic and cartography
GoldenPath	LEP  -  7q31.3   chr7:127668567-127684917 +  7q32.1   [Description]    (hg18-March_2006)
Ensembl	LEP - 7q32.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	LEP
	Gene and transcription
Genbank	AF008123 [ ENTREZ ]
Genbank	BC060830 [ ENTREZ ]
Genbank	BC069323 [ ENTREZ ]
Genbank	BC069452 [ ENTREZ ]
Genbank	BC069527 [ ENTREZ ]
RefSeq	NM_000230 [ SRS ]    NM_000230 [ ENTREZ ]
RefSeq	AC_000050 [ SRS ]    AC_000050 [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NT_007933 [ SRS ]    NT_007933 [ ENTREZ ]
RefSeq	NT_079596 [ SRS ]    NT_079596 [ ENTREZ ]
RefSeq	NW_923640 [ SRS ]    NW_923640 [ ENTREZ ]
AceView	LEP AceView - NCBI
Unigene	Hs.194236 [ SRS ]    Hs.194236 [ NCBI ]     HS194236 [ spliceNest ]
Fast-db	11441 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P41159 [ SRS]    P41159 [ EXPASY ]     P41159 [ INTERPRO ]
Interpro	IPR012351 4_helix_cytokine_core [ SRS ]    IPR012351 4_helix_cytokine_core [ EBI ]
Interpro	IPR000065 Leptin [ SRS ]    IPR000065 Leptin [ EBI ]
CluSTr	P41159
Pfam	PF02024 Leptin [ SRS ]    PF02024 Leptin [ Sanger ]    pfam02024 [ NCBI-CDD ]
Prodom	PD005698 Leptin[INRA-Toulouse]
Prodom	P41159 LEP_HUMAN [ Domain structure ]   P41159 LEP_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P41159
PDB	1AX8 [ SRS ]    1AX8 [ PdbSum ],   1AX8 [ IMB ]   1AX8 [ RSDB ]
HPRD	01249
	Protein Interaction databases
DIP	P41159
IntAct	P41159
	Polymorphism : SNP, mutations, diseases
OMIM	164160    [ map ]
GENECLINICS	164160
SNP	LEP [dbSNP-NCBI]
SNP	NM_000230 [SNP-NCI]
SNP	LEP [GeneSNPs - Utah]  LEP] [HGBASE - SRS]
HAPMAP	LEP [HAPMAP]
HGMD	LEP
	General knowledge
Family Browser	LEP [UCSC Family Browser]
SOURCE	NM_000230
SMD	Hs.194236
SAGE	Hs.194236
GO	hormone activity [Amigo]  hormone activity
GO	protein binding [Amigo]  protein binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	glucose metabolic process [Amigo]  glucose metabolic process
GO	energy reserve metabolic process [Amigo]  energy reserve metabolic process
GO	lipid metabolic process [Amigo]  lipid metabolic process
GO	signal transduction [Amigo]  signal transduction
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	growth factor activity [Amigo]  growth factor activity
GO	cholesterol metabolic process [Amigo]  cholesterol metabolic process
GO	bile acid metabolic process [Amigo]  bile acid metabolic process
GO	adult feeding behavior [Amigo]  adult feeding behavior
GO	regulation of metabolic process [Amigo]  regulation of metabolic process
GO	regulation of cholesterol absorption [Amigo]  regulation of cholesterol absorption
GO	negative regulation of appetite [Amigo]  negative regulation of appetite
GO	eating behavior [Amigo]  eating behavior
GO	positive regulation of myeloid cell differentiation [Amigo]  positive regulation of myeloid cell differentiation
BIOCARTA	Reversal of Insulin Resistance by Leptin    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	Neuroactive ligand-receptor interaction
KEGG	Jak-STAT signaling pathway
KEGG	Adipocytokine signaling pathway
PubGene	LEP
TreeFam	LEP
CTD	3952 [Comparative Genomics Database]
	Other databases
	Probes
Probe	LEP Related clones (RZPD - Berlin)
	PubMed
PubMed	386 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:14:13 2008