Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LEP (leptin)

Identity

Other namesLEPD
OB
OBS
HGNC (Hugo) LEP
LocusID (NCBI) 3952
Location 7q32.1
Location_base_pair Starts at 127881331 and ends at 127897682 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LEP   6553
Cards
Entrez_Gene (NCBI)LEP  3952  leptin
GeneCards (Weizmann)LEP
Ensembl (Hinxton)ENSG00000174697 [Gene_View]  chr7:127881331-127897682 [Contig_View]  LEP [Vega]
ICGC DataPortalENSG00000174697
cBioPortalLEP
AceView (NCBI)LEP
Genatlas (Paris)LEP
WikiGenes3952
SOURCE (Princeton)NM_000230
Genomic and cartography
GoldenPath (UCSC)LEP  -  7q32.1   chr7:127881331-127897682 +  7q32.1   [Description]    (hg19-Feb_2009)
EnsemblLEP - 7q32.1 [CytoView]
Mapping of homologs : NCBILEP [Mapview]
OMIM164160   614962   
Gene and transcription
Genbank (Entrez)AF008123 AK313553 BC060830 BC069323 BC069452
RefSeq transcript (Entrez)NM_000230
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_007450 NT_007933 NW_001839071 NW_004929332
Consensus coding sequences : CCDS (NCBI)LEP
Cluster EST : UnigeneHs.194236 [ NCBI ]
CGAP (NCI)Hs.194236
Alternative Splicing : Fast-db (Paris)GSHG0027697
Alternative Splicing GalleryENSG00000174697
Gene ExpressionLEP [ NCBI-GEO ]     LEP [ SEEK ]   LEP [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41159 (Uniprot)
NextProtP41159  [Medical]
With graphics : InterProP41159
Splice isoforms : SwissVarP41159 (Swissvar)
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   Leptin [organisation]  
Related proteins : CluSTrP41159
Domain families : Pfam (Sanger)Leptin (PF02024)   
Domain families : Pfam (NCBI)pfam02024   
Domain structure : Prodom (Prabi Lyon)Leptin (PD005698)   
DMDM Disease mutations3952
Blocks (Seattle)P41159
PDB (SRS)1AX8   
PDB (PDBSum)1AX8   
PDB (IMB)1AX8   
PDB (RSDB)1AX8   
Human Protein AtlasENSG00000174697 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP41159
HPRD01249
IPIIPI00012760   
Protein Interaction databases
DIP (DOE-UCLA)P41159
IntAct (EBI)P41159
FunCoupENSG00000174697
BioGRIDLEP
InParanoidP41159
Interologous Interaction database P41159
IntegromeDBLEP
STRING (EMBL)LEP
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  ovulation from ovarian follicle  response to hypoxia  positive regulation of cytokine production  placenta development  response to dietary excess  hormone activity  extracellular region  extracellular space  cytoplasm  glucose metabolic process  regulation of gluconeogenesis  energy reserve metabolic process  glycerol biosynthetic process  tyrosine phosphorylation of STAT protein  female pregnancy  circadian rhythm  growth factor activity  cholesterol metabolic process  bile acid metabolic process  regulation of blood pressure  positive regulation of cell proliferation  adult feeding behavior  fatty acid catabolic process  central nervous system neuron development  insulin secretion  regulation of intestinal cholesterol absorption  negative regulation of appetite  response to insulin  response to vitamin E  leptin-mediated signaling pathway  positive regulation of luteinizing hormone secretion  bone mineralization involved in bone maturation  hormone metabolic process  positive regulation of tyrosine phosphorylation of Stat3 protein  eating behavior  negative regulation of apoptotic process  positive regulation of ion transport  positive regulation of MAPK cascade  regulation of fat cell differentiation  positive regulation of myeloid cell differentiation  negative regulation of vasoconstriction  positive regulation of insulin receptor signaling pathway  positive regulation of follicle-stimulating hormone secretion  positive regulation of developmental growth  regulation of insulin secretion  regulation of steroid biosynthetic process  leukocyte tethering or rolling  peptide hormone receptor binding  regulation of lipoprotein lipid oxidation  adipose tissue development  negative regulation of cartilage development  negative regulation of glucagon secretion  cellular response to L-ascorbic acid  cellular response to retinoic acid  positive regulation of STAT protein import into nucleus  negative regulation of glutamine transport  positive regulation of hepatic stellate cell activation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  ovulation from ovarian follicle  response to hypoxia  positive regulation of cytokine production  placenta development  response to dietary excess  hormone activity  extracellular region  extracellular space  cytoplasm  glucose metabolic process  regulation of gluconeogenesis  energy reserve metabolic process  glycerol biosynthetic process  tyrosine phosphorylation of STAT protein  female pregnancy  circadian rhythm  growth factor activity  cholesterol metabolic process  bile acid metabolic process  regulation of blood pressure  positive regulation of cell proliferation  adult feeding behavior  fatty acid catabolic process  central nervous system neuron development  insulin secretion  regulation of intestinal cholesterol absorption  negative regulation of appetite  response to insulin  response to vitamin E  leptin-mediated signaling pathway  positive regulation of luteinizing hormone secretion  bone mineralization involved in bone maturation  hormone metabolic process  positive regulation of tyrosine phosphorylation of Stat3 protein  eating behavior  negative regulation of apoptotic process  positive regulation of ion transport  positive regulation of MAPK cascade  regulation of fat cell differentiation  positive regulation of myeloid cell differentiation  negative regulation of vasoconstriction  positive regulation of insulin receptor signaling pathway  positive regulation of follicle-stimulating hormone secretion  positive regulation of developmental growth  regulation of insulin secretion  regulation of steroid biosynthetic process  leukocyte tethering or rolling  peptide hormone receptor binding  regulation of lipoprotein lipid oxidation  adipose tissue development  negative regulation of cartilage development  negative regulation of glucagon secretion  cellular response to L-ascorbic acid  cellular response to retinoic acid  positive regulation of STAT protein import into nucleus  negative regulation of glutamine transport  positive regulation of hepatic stellate cell activation  
Pathways : BIOCARTAReversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    Jak-STAT signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)   
Protein Interaction DatabaseLEP
Wikipedia pathwaysLEP
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LEP
snp3D : Map Gene to Disease3952
SNP (GeneSNP Utah)LEP
SNP : HGBaseLEP
Genetic variants : HAPMAPLEP
Exome VariantLEP
1000_GenomesLEP 
ICGC programENSG00000174697 
Somatic Mutations in Cancer : COSMICLEP 
CONAN: Copy Number AnalysisLEP 
Mutations and Diseases : HGMDLEP
Mutations and Diseases : intOGenLEP
Genomic VariantsLEP  LEP [DGVbeta]
dbVarLEP
ClinVarLEP
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM164160    614962   
MedgenLEP
GENETestsLEP
Disease Genetic AssociationLEP
Huge Navigator LEP [HugePedia]  LEP [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneLEP
Homology/Alignments : Family Browser (UCSC)LEP
Phylogenetic Trees/Animal Genes : TreeFamLEP
Chemical/Protein Interactions : CTD3952
Chemical/Pharm GKB GenePA228
Clinical trialLEP
Cancer Resource (Charite)ENSG00000174697
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineLEP
iHOPLEP
OncoSearchLEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 18:59:12 CEST 2014

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