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LEPR (leptin receptor)

Identity

Other namesCD295
LEP-R
LEPRD
OB-R
OBR
HGNC (Hugo) LEPR
LocusID (NCBI) 3953
Atlas_Id 43957
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 65886335 and ends at 66101111 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MIER1 (1p31.3) / LEPR (1p31.3)MIER1 1p31.3 / LEPR 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LEPR   6554
Cards
Entrez_Gene (NCBI)LEPR  3953  leptin receptor
AliasesCD295; LEP-R; LEPRD; OB-R; 
OBR
GeneCards (Weizmann)LEPR
Ensembl hg19 (Hinxton)ENSG00000116678 [Gene_View]  chr1:65886335-66101111 [Contig_View]  LEPR [Vega]
Ensembl hg38 (Hinxton)ENSG00000116678 [Gene_View]  chr1:65886335-66101111 [Contig_View]  LEPR [Vega]
ICGC DataPortalENSG00000116678
TCGA cBioPortalLEPR
AceView (NCBI)LEPR
Genatlas (Paris)LEPR
WikiGenes3953
SOURCE (Princeton)LEPR
Genomic and cartography
GoldenPath hg19 (UCSC)LEPR  -     chr1:65886335-66101111 +  1p31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEPR  -     1p31.3   [Description]    (hg38-Dec_2013)
EnsemblLEPR - 1p31.3 [CytoView hg19]  LEPR - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBILEPR [Mapview hg19]  LEPR [Mapview hg38]
OMIM601007   614963   
Gene and transcription
Genbank (Entrez)AA813024 AI436180 AK001042 AK290208 AW302522
RefSeq transcript (Entrez)NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689 NM_002303
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_015831 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)LEPR
Cluster EST : UnigeneHs.723178 [ NCBI ]
CGAP (NCI)Hs.723178
Alternative Splicing GalleryENSG00000116678
Gene ExpressionLEPR [ NCBI-GEO ]   LEPR [ EBI - ARRAY_EXPRESS ]   LEPR [ SEEK ]   LEPR [ MEM ]
Gene Expression Viewer (FireBrowse)LEPR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3953
GTEX Portal (Tissue expression)LEPR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48357 (Uniprot)
NextProtP48357  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48357
Splice isoforms : SwissVarP48357 (Swissvar)
PhosPhoSitePlusP48357
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)FN3_dom    Hematopoietin_rcpt_Gp130_CS    Hempt_rcpt_S_F1_CS    Ig-like_dom    Ig-like_fold    IgC2-like_lig-bd    Lep_receptor   
Domain families : Pfam (Sanger)Lep_receptor_Ig (PF06328)   
Domain families : Pfam (NCBI)pfam06328   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3953
Blocks (Seattle)LEPR
PDB (SRS)3V6O   
PDB (PDBSum)3V6O   
PDB (IMB)3V6O   
PDB (RSDB)3V6O   
Structural Biology KnowledgeBase3V6O   
SCOP (Structural Classification of Proteins)3V6O   
CATH (Classification of proteins structures)3V6O   
SuperfamilyP48357
Human Protein AtlasENSG00000116678
Peptide AtlasP48357
HPRD03001
IPIIPI00009243   IPI00219708   IPI00219709   IPI00219710   IPI00219711   IPI01014481   
Protein Interaction databases
DIP (DOE-UCLA)P48357
IntAct (EBI)P48357
FunCoupENSG00000116678
BioGRIDLEPR
STRING (EMBL)LEPR
ZODIACLEPR
Ontologies - Pathways
QuickGOP48357
Ontology : AmiGOangiogenesis  transmembrane signaling receptor activity  protein binding  extracellular region  plasma membrane  energy reserve metabolic process  cell surface receptor signaling pathway  multicellular organism development  cholesterol metabolic process  negative regulation of autophagy  integral component of membrane  basolateral plasma membrane  sexual reproduction  T cell differentiation  leptin-mediated signaling pathway  leptin receptor activity  glucose homeostasis  identical protein binding  receptor complex  response to leptin  negative regulation of gluconeogenesis  regulation of bone remodeling  negative regulation of hydrolase activity  regulation of feeding behavior  energy homeostasis  bone growth  regulation of energy homeostasis  
Ontology : EGO-EBIangiogenesis  transmembrane signaling receptor activity  protein binding  extracellular region  plasma membrane  energy reserve metabolic process  cell surface receptor signaling pathway  multicellular organism development  cholesterol metabolic process  negative regulation of autophagy  integral component of membrane  basolateral plasma membrane  sexual reproduction  T cell differentiation  leptin-mediated signaling pathway  leptin receptor activity  glucose homeostasis  identical protein binding  receptor complex  response to leptin  negative regulation of gluconeogenesis  regulation of bone remodeling  negative regulation of hydrolase activity  regulation of feeding behavior  energy homeostasis  bone growth  regulation of energy homeostasis  
Pathways : BIOCARTAReversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    Jak-STAT signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)   
NDEx Network
Atlas of Cancer Signalling NetworkLEPR
Wikipedia pathwaysLEPR
Orthology - Evolution
OrthoDB3953
GeneTree (enSembl)ENSG00000116678
Phylogenetic Trees/Animal Genes : TreeFamLEPR
Homologs : HomoloGeneLEPR
Homology/Alignments : Family Browser (UCSC)LEPR
Gene fusions - Rearrangements
Fusion: TCGAMIER1 1p31.3 LEPR 1p31.3 SKCM
Polymorphisms : SNP, variants
NCBI Variation ViewerLEPR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEPR
dbVarLEPR
ClinVarLEPR
1000_GenomesLEPR 
Exome Variant ServerLEPR
ExAC (Exome Aggregation Consortium)LEPR (select the gene name)
Genetic variants : HAPMAP3953
Genomic Variants (DGV)LEPR [DGVbeta]
Mutations
ICGC Data PortalLEPR 
TCGA Data PortalLEPR 
Broad Tumor PortalLEPR
OASIS PortalLEPR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEPR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LEPR
DgiDB (Drug Gene Interaction Database)LEPR
DoCM (Curated mutations)LEPR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEPR (select a term)
intoGenLEPR
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:65886335-66101111  ENSG00000116678
CONAN: Copy Number AnalysisLEPR 
Mutations and Diseases : HGMDLEPR
OMIM601007    614963   
MedgenLEPR
Genetic Testing Registry LEPR
NextProtP48357 [Medical]
TSGene3953
GENETestsLEPR
Huge Navigator LEPR [HugePedia]
snp3D : Map Gene to Disease3953
BioCentury BCIQLEPR
ClinGenLEPR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3953
Chemical/Pharm GKB GenePA229
Clinical trialLEPR
Miscellaneous
canSAR (ICR)LEPR (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEPR
EVEXLEPR
GoPubMedLEPR
iHOPLEPR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:07 CEST 2016

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