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LEPR (leptin receptor)

Identity

Other namesCD295
LEP-R
LEPRD
OB-R
OBR
HGNC (Hugo) LEPR
LocusID (NCBI) 3953
Location 1p31.3
Location_base_pair Starts at 65886335 and ends at 66101111 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LEPR   6554
Cards
Entrez_Gene (NCBI)LEPR  3953  leptin receptor
GeneCards (Weizmann)LEPR
Ensembl hg19 (Hinxton)ENSG00000116678 [Gene_View]  chr1:65886335-66101111 [Contig_View]  LEPR [Vega]
Ensembl hg38 (Hinxton)ENSG00000116678 [Gene_View]  chr1:65886335-66101111 [Contig_View]  LEPR [Vega]
ICGC DataPortalENSG00000116678
cBioPortalLEPR
AceView (NCBI)LEPR
Genatlas (Paris)LEPR
WikiGenes3953
SOURCE (Princeton)LEPR
Genomic and cartography
GoldenPath hg19 (UCSC)LEPR  -     chr1:65886335-66101111 +  1p31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEPR  -     1p31.3   [Description]    (hg38-Dec_2013)
EnsemblLEPR - 1p31.3 [CytoView hg19]  LEPR - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBILEPR [Mapview hg19]  LEPR [Mapview hg38]
OMIM601007   614963   
Gene and transcription
Genbank (Entrez)AA813024 AI436180 AK001042 AK290208 AW302522
RefSeq transcript (Entrez)NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689 NM_002303
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_015831 NT_032977 NW_001838579 NW_004929290
Consensus coding sequences : CCDS (NCBI)LEPR
Cluster EST : UnigeneHs.723178 [ NCBI ]
CGAP (NCI)Hs.723178
Alternative Splicing : Fast-db (Paris)GSHG0000600
Alternative Splicing GalleryENSG00000116678
Gene ExpressionLEPR [ NCBI-GEO ]     LEPR [ SEEK ]   LEPR [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48357 (Uniprot)
NextProtP48357  [Medical]
With graphics : InterProP48357
Splice isoforms : SwissVarP48357 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)Fibronectin_type3    Hematopoietin_rcpt_Gp130_CS    Hempt_rcpt_S_F1_CS    Ig-like_dom    Ig-like_fold    IgC2-like_lig-bd    Lep_receptor   
Related proteins : CluSTrP48357
Domain families : Pfam (Sanger)Lep_receptor_Ig (PF06328)   
Domain families : Pfam (NCBI)pfam06328   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3953
Blocks (Seattle)P48357
PDB (SRS)3V6O   
PDB (PDBSum)3V6O   
PDB (IMB)3V6O   
PDB (RSDB)3V6O   
Human Protein AtlasENSG00000116678
Peptide AtlasP48357
HPRD03001
IPIIPI00009243   IPI00219708   IPI00219709   IPI00219710   IPI00219711   IPI01014481   
Protein Interaction databases
DIP (DOE-UCLA)P48357
IntAct (EBI)P48357
FunCoupENSG00000116678
BioGRIDLEPR
IntegromeDBLEPR
STRING (EMBL)LEPR
Ontologies - Pathways
QuickGOP48357
Ontology : AmiGOtransmembrane signaling receptor activity  cytokine receptor activity  protein binding  extracellular region  plasma membrane  energy reserve metabolic process  cell surface receptor signaling pathway  multicellular organismal development  cholesterol metabolic process  integral component of membrane  cytokine-mediated signaling pathway  identical protein binding  receptor complex  negative regulation of hydrolase activity  
Ontology : EGO-EBItransmembrane signaling receptor activity  cytokine receptor activity  protein binding  extracellular region  plasma membrane  energy reserve metabolic process  cell surface receptor signaling pathway  multicellular organismal development  cholesterol metabolic process  integral component of membrane  cytokine-mediated signaling pathway  identical protein binding  receptor complex  negative regulation of hydrolase activity  
Pathways : BIOCARTAReversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Neuroactive ligand-receptor interaction    Jak-STAT signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)   
Protein Interaction DatabaseLEPR
DoCM (Curated mutations)LEPR
Wikipedia pathwaysLEPR
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLEPR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEPR
dbVarLEPR
ClinVarLEPR
1000_GenomesLEPR 
Exome Variant ServerLEPR
SNP (GeneSNP Utah)LEPR
SNP : HGBaseLEPR
Genetic variants : HAPMAPLEPR
Genomic VariantsLEPR  LEPR [DGVbeta]
Mutations
ICGC Data PortalENSG00000116678 
Somatic Mutations in Cancer : COSMICLEPR 
CONAN: Copy Number AnalysisLEPR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:65886335-66101111
Mutations and Diseases : HGMDLEPR
OMIM601007    614963   
MedgenLEPR
NextProtP48357 [Medical]
GENETestsLEPR
Disease Genetic AssociationLEPR
Huge Navigator LEPR [HugePedia]  LEPR [HugeCancerGEM]
snp3D : Map Gene to Disease3953
DGIdb (Drug Gene Interaction db)LEPR
General knowledge
Homologs : HomoloGeneLEPR
Homology/Alignments : Family Browser (UCSC)LEPR
Phylogenetic Trees/Animal Genes : TreeFamLEPR
Chemical/Protein Interactions : CTD3953
Chemical/Pharm GKB GenePA229
Clinical trialLEPR
Cancer Resource (Charite)ENSG00000116678
Other databases
Probes
Litterature
PubMed456 Pubmed reference(s) in Entrez
CoreMineLEPR
GoPubMedLEPR
iHOPLEPR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:26:54 CET 2014

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