Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LEPRE1 (leucine proline-enriched proteoglycan (leprecan) 1)

Identity

Other namesGROS1
OI8
P3H1
HGNC (Hugo) LEPRE1
LocusID (NCBI) 64175
Location 1p34.2
Location_base_pair Starts at 43212006 and ends at 43232755 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LEPRE1   19316
Cards
Entrez_Gene (NCBI)LEPRE1  64175  leucine proline-enriched proteoglycan (leprecan) 1
GeneCards (Weizmann)LEPRE1
Ensembl (Hinxton)ENSG00000117385 [Gene_View]  chr1:43212006-43232755 [Contig_View]  LEPRE1 [Vega]
ICGC DataPortalENSG00000117385
AceView (NCBI)LEPRE1
Genatlas (Paris)LEPRE1
WikiGenes64175
SOURCE (Princeton)NM_001146289 NM_001243246 NM_022356
Genomic and cartography
GoldenPath (UCSC)LEPRE1  -  1p34.2   chr1:43212006-43232755 -  1p34.2   [Description]    (hg19-Feb_2009)
EnsemblLEPRE1 - 1p34.2 [CytoView]
Mapping of homologs : NCBILEPRE1 [Mapview]
OMIM610339   610915   
Gene and transcription
Genbank (Entrez)AF097431 AF097432 AK025841 AK027648 AK027680
RefSeq transcript (Entrez)NM_001146289 NM_001243246 NM_022356
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008123 NT_032977 NW_001838578 NW_004929290
Consensus coding sequences : CCDS (NCBI)LEPRE1
Cluster EST : UnigeneHs.720014 [ NCBI ]
CGAP (NCI)Hs.720014
Alternative Splicing : Fast-db (Paris)GSHG0002031
Alternative Splicing GalleryENSG00000117385
Gene ExpressionLEPRE1 [ NCBI-GEO ]     LEPRE1 [ SEEK ]   LEPRE1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ32P28 (Uniprot)
NextProtQ32P28  [Medical]
With graphics : InterProQ32P28
Splice isoforms : SwissVarQ32P28 (Swissvar)
Catalytic activity : Enzyme1.14.11.7 [ Enzyme-Expasy ]   1.14.11.71.14.11.7 [ IntEnz-EBI ]   1.14.11.7 [ BRENDA ]   1.14.11.7 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    FE2OG_OXY (PS51471)   
Domains : Interpro (EBI)Oxoglu/Fe-dep_dioxygenase    Pro_4_hyd_alph    TPR-like_helical   
Related proteins : CluSTrQ32P28
Domain families : Pfam (Sanger)2OG-FeII_Oxy_3 (PF13640)   
Domain families : Pfam (NCBI)pfam13640   
Domain families : Smart (EMBL)P4Hc (SM00702)  
DMDM Disease mutations64175
Blocks (Seattle)Q32P28
Human Protein AtlasENSG00000117385
Peptide AtlasQ32P28
HPRD11227
IPIIPI00163381   IPI00761114   IPI00045839   IPI01013314   IPI00916562   IPI00644560   IPI00916709   
Protein Interaction databases
DIP (DOE-UCLA)Q32P28
IntAct (EBI)Q32P28
FunCoupENSG00000117385
BioGRIDLEPRE1
InParanoidQ32P28
Interologous Interaction database Q32P28
IntegromeDBLEPRE1
STRING (EMBL)LEPRE1
Ontologies - Pathways
Ontology : AmiGOmolecular_function  iron ion binding  collagen binding  proteinaceous extracellular matrix  nucleus  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  negative regulation of cell proliferation  membrane  cell growth  protein hydroxylation  peptidyl-proline hydroxylation  peptidyl-proline hydroxylation  procollagen-proline 3-dioxygenase activity  extracellular matrix organization  collagen fibril organization  regulation of ossification  L-ascorbic acid binding  protein complex binding  collagen metabolic process  macromolecular complex  regulation of protein secretion  protein stabilization  oxidation-reduction process  bone development  chaperone-mediated protein folding  extracellular vesicular exosome  negative regulation of post-translational protein modification  
Ontology : EGO-EBImolecular_function  iron ion binding  collagen binding  proteinaceous extracellular matrix  nucleus  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  negative regulation of cell proliferation  membrane  cell growth  protein hydroxylation  peptidyl-proline hydroxylation  peptidyl-proline hydroxylation  procollagen-proline 3-dioxygenase activity  extracellular matrix organization  collagen fibril organization  regulation of ossification  L-ascorbic acid binding  protein complex binding  collagen metabolic process  macromolecular complex  regulation of protein secretion  protein stabilization  oxidation-reduction process  bone development  chaperone-mediated protein folding  extracellular vesicular exosome  negative regulation of post-translational protein modification  
Protein Interaction DatabaseLEPRE1
Wikipedia pathwaysLEPRE1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LEPRE1
SNP (GeneSNP Utah)LEPRE1
SNP : HGBaseLEPRE1
Genetic variants : HAPMAPLEPRE1
1000_GenomesLEPRE1 
ICGC programENSG00000117385 
CONAN: Copy Number AnalysisLEPRE1 
Somatic Mutations in Cancer : COSMICLEPRE1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Osteogenesis Imperfecta Variant Database
Mutations and Diseases : HGMDLEPRE1
OMIM610339    610915   
MedgenLEPRE1
GENETestsLEPRE1
Disease Genetic AssociationLEPRE1
Huge Navigator LEPRE1 [HugePedia]  LEPRE1 [HugeCancerGEM]
Genomic VariantsLEPRE1  LEPRE1 [DGVbeta]
Exome VariantLEPRE1
dbVarLEPRE1
ClinVarLEPRE1
snp3D : Map Gene to Disease64175
General knowledge
Homologs : HomoloGeneLEPRE1
Homology/Alignments : Family Browser (UCSC)LEPRE1
Phylogenetic Trees/Animal Genes : TreeFamLEPRE1
Chemical/Protein Interactions : CTD64175
Chemical/Pharm GKB GenePA134930599
Clinical trialLEPRE1
Cancer Resource (Charite)ENSG00000117385
Other databases
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
CoreMineLEPRE1
iHOPLEPRE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:55:48 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.