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LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)

Identity

Alias_namesleucine zipper-EF-hand containing transmembrane protein 1
Other alias-
HGNC (Hugo) LETM1
LocusID (NCBI) 3954
Atlas_Id 50978
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 1811479 and ends at 1856247 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LETM1 (4p16.3) / ERC1 (12p13.33)LETM1 (4p16.3) / USP15 (12q14.1)SLBP (4p16.3) / LETM1 (4p16.3)
TSC22D1 (13q14.11) / LETM1 (4p16.3)SLBP 4p16.3 / LETM1 4p16.3TSC22D1 13q14.11 / LETM1 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LETM1   6556
Cards
Entrez_Gene (NCBI)LETM1  3954  leucine zipper and EF-hand containing transmembrane protein 1
Aliases
GeneCards (Weizmann)LETM1
Ensembl hg19 (Hinxton)ENSG00000168924 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168924 [Gene_View]  chr4:1811479-1856247 [Contig_View]  LETM1 [Vega]
ICGC DataPortalENSG00000168924
TCGA cBioPortalLETM1
AceView (NCBI)LETM1
Genatlas (Paris)LETM1
WikiGenes3954
SOURCE (Princeton)LETM1
Genetics Home Reference (NIH)LETM1
Genomic and cartography
GoldenPath hg38 (UCSC)LETM1  -     chr4:1811479-1856247 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LETM1  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblLETM1 - 4p16.3 [CytoView hg19]  LETM1 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBILETM1 [Mapview hg19]  LETM1 [Mapview hg38]
OMIM194190   604407   
Gene and transcription
Genbank (Entrez)AF061025 AK293572 AK310563 AL133650 BC014500
RefSeq transcript (Entrez)NM_012318
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LETM1
Cluster EST : UnigeneHs.120165 [ NCBI ]
CGAP (NCI)Hs.120165
Alternative Splicing GalleryENSG00000168924
Gene ExpressionLETM1 [ NCBI-GEO ]   LETM1 [ EBI - ARRAY_EXPRESS ]   LETM1 [ SEEK ]   LETM1 [ MEM ]
Gene Expression Viewer (FireBrowse)LETM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3954
GTEX Portal (Tissue expression)LETM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95202   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95202  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95202
Splice isoforms : SwissVarO95202
PhosPhoSitePlusO95202
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    LETM1_RBD (PS51758)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    LETM1    LETM1_RBD   
Domain families : Pfam (Sanger)LETM1 (PF07766)   
Domain families : Pfam (NCBI)pfam07766   
Conserved Domain (NCBI)LETM1
DMDM Disease mutations3954
Blocks (Seattle)LETM1
SuperfamilyO95202
Human Protein AtlasENSG00000168924
Peptide AtlasO95202
HPRD05101
IPIIPI00017592   IPI00941879   IPI00941510   IPI01026554   
Protein Interaction databases
DIP (DOE-UCLA)O95202
IntAct (EBI)O95202
FunCoupENSG00000168924
BioGRIDLETM1
STRING (EMBL)LETM1
ZODIACLETM1
Ontologies - Pathways
QuickGOO95202
Ontology : AmiGOcalcium ion binding  protein binding  mitochondrion  mitochondrion  mitochondrial inner membrane  cellular metal ion homeostasis  integral component of membrane  cristae formation  ribosome binding  
Ontology : EGO-EBIcalcium ion binding  protein binding  mitochondrion  mitochondrion  mitochondrial inner membrane  cellular metal ion homeostasis  integral component of membrane  cristae formation  ribosome binding  
NDEx NetworkLETM1
Atlas of Cancer Signalling NetworkLETM1
Wikipedia pathwaysLETM1
Orthology - Evolution
OrthoDB3954
GeneTree (enSembl)ENSG00000168924
Phylogenetic Trees/Animal Genes : TreeFamLETM1
HOVERGENO95202
HOGENOMO95202
Homologs : HomoloGeneLETM1
Homology/Alignments : Family Browser (UCSC)LETM1
Gene fusions - Rearrangements
Fusion : MitelmanLETM1/USP15 [4p16.3/12q14.1]  
Fusion : MitelmanSLBP/LETM1 [4p16.3/4p16.3]  [t(4;4)(p16;p16)]  
Fusion : MitelmanTSC22D1/LETM1 [13q14.11/4p16.3]  [t(4;13)(p16;q14)]  
Fusion: TCGASLBP 4p16.3 LETM1 4p16.3 HNSC
Fusion: TCGATSC22D1 13q14.11 LETM1 4p16.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLETM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LETM1
dbVarLETM1
ClinVarLETM1
1000_GenomesLETM1 
Exome Variant ServerLETM1
ExAC (Exome Aggregation Consortium)LETM1 (select the gene name)
Genetic variants : HAPMAP3954
Genomic Variants (DGV)LETM1 [DGVbeta]
DECIPHERLETM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLETM1 
Mutations
ICGC Data PortalLETM1 
TCGA Data PortalLETM1 
Broad Tumor PortalLETM1
OASIS PortalLETM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLETM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLETM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LETM1
DgiDB (Drug Gene Interaction Database)LETM1
DoCM (Curated mutations)LETM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LETM1 (select a term)
intoGenLETM1
Cancer3DLETM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM194190    604407   
Orphanet147   
MedgenLETM1
Genetic Testing Registry LETM1
NextProtO95202 [Medical]
TSGene3954
GENETestsLETM1
Target ValidationLETM1
Huge Navigator LETM1 [HugePedia]
snp3D : Map Gene to Disease3954
BioCentury BCIQLETM1
ClinGenLETM1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3954
Chemical/Pharm GKB GenePA30335
Clinical trialLETM1
Miscellaneous
canSAR (ICR)LETM1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLETM1
EVEXLETM1
GoPubMedLETM1
iHOPLETM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:57:33 CEST 2017

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