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LETM2 (leucine zipper and EF-hand containing transmembrane protein 2)

Identity

Alias_namesleucine zipper-EF-hand containing transmembrane protein 2
Alias_symbol (synonym)FLJ25409
Other alias-
HGNC (Hugo) LETM2
LocusID (NCBI) 137994
Atlas_Id 54423
Location 8p11.23  [Link to chromosome band 8p11]
Location_base_pair Starts at 38386441 and ends at 38409524 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KIAA0556 (16p12.1) / LETM2 (8p11.23)LETM2 (8p11.23) / KCNU1 (8p11.23)NSMAF (8q12.1) / LETM2 (8p11.23)
OSBPL1A (18q11.2) / LETM2 (8p11.23)NSMAF 8q12.1 / LETM2 8p11.23OSBPL1A 18q11.2 / LETM2 8p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)LETM2   14648
Cards
Entrez_Gene (NCBI)LETM2  137994  leucine zipper and EF-hand containing transmembrane protein 2
Aliases
GeneCards (Weizmann)LETM2
Ensembl hg19 (Hinxton)ENSG00000165046 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165046 [Gene_View]  chr8:38386441-38409524 [Contig_View]  LETM2 [Vega]
ICGC DataPortalENSG00000165046
TCGA cBioPortalLETM2
AceView (NCBI)LETM2
Genatlas (Paris)LETM2
WikiGenes137994
SOURCE (Princeton)LETM2
Genetics Home Reference (NIH)LETM2
Genomic and cartography
GoldenPath hg38 (UCSC)LETM2  -     chr8:38386441-38409524 +  8p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LETM2  -     8p11.23   [Description]    (hg19-Feb_2009)
EnsemblLETM2 - 8p11.23 [CytoView hg19]  LETM2 - 8p11.23 [CytoView hg38]
Mapping of homologs : NCBILETM2 [Mapview hg19]  LETM2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK058138 AK289944 AK302317 AK302474 AL832241
RefSeq transcript (Entrez)NM_001199659 NM_001199660 NM_001286787 NM_001286819 NM_001286821 NM_001330515 NM_144652
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LETM2
Cluster EST : UnigeneHs.734005 [ NCBI ]
CGAP (NCI)Hs.734005
Alternative Splicing GalleryENSG00000165046
Gene ExpressionLETM2 [ NCBI-GEO ]   LETM2 [ EBI - ARRAY_EXPRESS ]   LETM2 [ SEEK ]   LETM2 [ MEM ]
Gene Expression Viewer (FireBrowse)LETM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137994
GTEX Portal (Tissue expression)LETM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ2VYF4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ2VYF4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ2VYF4
Splice isoforms : SwissVarQ2VYF4
PhosPhoSitePlusQ2VYF4
Domaine pattern : Prosite (Expaxy)LETM1_RBD (PS51758)   
Domains : Interpro (EBI)LETM1    LETM1_RBD   
Domain families : Pfam (Sanger)LETM1 (PF07766)   
Domain families : Pfam (NCBI)pfam07766   
Conserved Domain (NCBI)LETM2
DMDM Disease mutations137994
Blocks (Seattle)LETM2
SuperfamilyQ2VYF4
Human Protein AtlasENSG00000165046
Peptide AtlasQ2VYF4
HPRD08060
IPIIPI00791632   IPI00869022   IPI00867594   IPI00922057   IPI00657815   IPI01009831   IPI00979577   IPI00985303   IPI00983419   IPI00982750   IPI00984108   IPI00982044   
Protein Interaction databases
DIP (DOE-UCLA)Q2VYF4
IntAct (EBI)Q2VYF4
FunCoupENSG00000165046
BioGRIDLETM2
STRING (EMBL)LETM2
ZODIACLETM2
Ontologies - Pathways
QuickGOQ2VYF4
Ontology : AmiGOmitochondrial inner membrane  cellular metal ion homeostasis  integral component of membrane  ribosome binding  
Ontology : EGO-EBImitochondrial inner membrane  cellular metal ion homeostasis  integral component of membrane  ribosome binding  
NDEx NetworkLETM2
Atlas of Cancer Signalling NetworkLETM2
Wikipedia pathwaysLETM2
Orthology - Evolution
OrthoDB137994
GeneTree (enSembl)ENSG00000165046
Phylogenetic Trees/Animal Genes : TreeFamLETM2
HOVERGENQ2VYF4
HOGENOMQ2VYF4
Homologs : HomoloGeneLETM2
Homology/Alignments : Family Browser (UCSC)LETM2
Gene fusions - Rearrangements
Fusion : MitelmanLETM2/KCNU1 [8p11.23/8p11.23]  
Fusion : MitelmanNSMAF/LETM2 [8q12.1/8p11.23]  [t(8;8)(p11;q12)]  
Fusion : MitelmanOSBPL1A/LETM2 [18q11.2/8p11.23]  [t(8;18)(p11;q11)]  
Fusion: TCGANSMAF 8q12.1 LETM2 8p11.23 BRCA
Fusion: TCGAOSBPL1A 18q11.2 LETM2 8p11.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLETM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LETM2
dbVarLETM2
ClinVarLETM2
1000_GenomesLETM2 
Exome Variant ServerLETM2
ExAC (Exome Aggregation Consortium)LETM2 (select the gene name)
Genetic variants : HAPMAP137994
Genomic Variants (DGV)LETM2 [DGVbeta]
DECIPHERLETM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLETM2 
Mutations
ICGC Data PortalLETM2 
TCGA Data PortalLETM2 
Broad Tumor PortalLETM2
OASIS PortalLETM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLETM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLETM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LETM2
DgiDB (Drug Gene Interaction Database)LETM2
DoCM (Curated mutations)LETM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LETM2 (select a term)
intoGenLETM2
Cancer3DLETM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenLETM2
Genetic Testing Registry LETM2
NextProtQ2VYF4 [Medical]
TSGene137994
GENETestsLETM2
Target ValidationLETM2
Huge Navigator LETM2 [HugePedia]
snp3D : Map Gene to Disease137994
BioCentury BCIQLETM2
ClinGenLETM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD137994
Chemical/Pharm GKB GenePA134887111
Clinical trialLETM2
Miscellaneous
canSAR (ICR)LETM2 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLETM2
EVEXLETM2
GoPubMedLETM2
iHOPLETM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:05:11 CEST 2017

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