LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

2012-08-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
SCDO3
FUSION GENES

Other Information

Locus ID:

NCBI: 3955
MIM: 602576
HGNC: 6560
Ensembl: ENSG00000106003

Variants:

dbSNP: 3955
ClinVar: 3955
TCGA: ENSG00000106003
COSMIC: LFNG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106003ENST00000222725Q8NES3
ENSG00000106003ENST00000338732Q8NES3
ENSG00000106003ENST00000359574Q8NES3
ENSG00000106003ENST00000402045Q8NES3
ENSG00000106003ENST00000402506Q8NES3
ENSG00000106003ENST00000614382A0A087X191

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Other types of O-glycan biosynthesisKEGGko00514
Notch signaling pathwayKEGGko04330
Other types of O-glycan biosynthesisKEGGhsa00514
Notch signaling pathwayKEGGhsa04330
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854472006Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype.53
226247132012Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.47
247094232014Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.13
262793022016Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.12
271568402016Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1.7
289381592017Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.3
291936072018Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.2
305318072019Identification of novel LFNG mutations in spondylocostal dysostosis.0

Citation

Dessen P

LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52840/lfng