Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LGALS1 (galectin 1)

Identity

Alias_nameslectin
Alias_symbol (synonym)GBP
Other aliasGAL1
HGNC (Hugo) LGALS1
LocusID (NCBI) 3956
Atlas_Id 46326
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 37675606 and ends at 37679802 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL1A2 (7q21.3) / LGALS1 (22q13.1)LGALS1 (22q13.1) / KLHL29 (2p24.1)LGALS1 (22q13.1) / MAGED1 (Xp11.22)
LGALS1 (22q13.1) / MTHFD2L (4q13.3)LGALS1 (22q13.1) / TF (3q22.1)TRIOBP (22q13.1) / LGALS1 (22q13.1)
UQCRC2 (16p12.2) / LGALS1 (22q13.1)VAMP2 (17p13.1) / LGALS1 (22q13.1)Z83844.2 () / LGALS1 (22q13.1)
Z83844.2 LGALS1 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(13q) in chronic lymphocytic leukemia

External links

Nomenclature
HGNC (Hugo)LGALS1   6561
Cards
Entrez_Gene (NCBI)LGALS1  3956  galectin 1
AliasesGAL1; GBP
GeneCards (Weizmann)LGALS1
Ensembl hg19 (Hinxton)ENSG00000100097 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100097 [Gene_View]  ENSG00000100097 [Sequence]  chr22:37675606-37679802 [Contig_View]  LGALS1 [Vega]
ICGC DataPortalENSG00000100097
TCGA cBioPortalLGALS1
AceView (NCBI)LGALS1
Genatlas (Paris)LGALS1
WikiGenes3956
SOURCE (Princeton)LGALS1
Genetics Home Reference (NIH)LGALS1
Genomic and cartography
GoldenPath hg38 (UCSC)LGALS1  -     chr22:37675606-37679802 +  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGALS1  -     7p22.3   [Description]    (hg19-Feb_2009)
EnsemblLGALS1 - 7p22.3 [CytoView hg19]  LGALS1 - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBILGALS1 [Mapview hg19]  LGALS1 [Mapview hg38]
OMIM150570   
Gene and transcription
Genbank (Entrez)AB097036 AK312161 AL832117 BC001693 BC020675
RefSeq transcript (Entrez)NM_002305
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGALS1
Cluster EST : UnigeneHs.445351 [ NCBI ]
CGAP (NCI)Hs.445351
Alternative Splicing GalleryENSG00000100097
Gene ExpressionLGALS1 [ NCBI-GEO ]   LGALS1 [ EBI - ARRAY_EXPRESS ]   LGALS1 [ SEEK ]   LGALS1 [ MEM ]
Gene Expression Viewer (FireBrowse)LGALS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3956
GTEX Portal (Tissue expression)LGALS1
Human Protein AtlasENSG00000100097-LGALS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09382   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09382  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09382
Splice isoforms : SwissVarP09382
PhosPhoSitePlusP09382
Domaine pattern : Prosite (Expaxy)GALECTIN (PS51304)   
Domains : Interpro (EBI)ConA-like_dom_sf    Galectin_CRD   
Domain families : Pfam (Sanger)Gal-bind_lectin (PF00337)   
Domain families : Pfam (NCBI)pfam00337   
Domain families : Smart (EMBL)Gal-bind_lectin (SM00908)  GLECT (SM00276)  
Conserved Domain (NCBI)LGALS1
DMDM Disease mutations3956
Blocks (Seattle)LGALS1
PDB (SRS)1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
PDB (PDBSum)1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
PDB (IMB)1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
PDB (RSDB)1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
Structural Biology KnowledgeBase1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
SCOP (Structural Classification of Proteins)1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
CATH (Classification of proteins structures)1GZW    1W6M    1W6N    1W6O    1W6P    1W6Q    2KM2    2ZKN    3OY8    3OYW    3T2T    3W58    3W59    4Q1P    4Q1R    4Q26    4Q27    4Q2F    4XBL    4Y1U    4Y1V    4Y1X    4Y1Y    4Y1Z    4Y20    4Y22    4Y24    5MWT    5MWX   
SuperfamilyP09382
Human Protein Atlas [tissue]ENSG00000100097-LGALS1 [tissue]
Peptide AtlasP09382
HPRD01040
IPIIPI00219219   IPI00879691   IPI00880148   
Protein Interaction databases
DIP (DOE-UCLA)P09382
IntAct (EBI)P09382
FunCoupENSG00000100097
BioGRIDLGALS1
STRING (EMBL)LGALS1
ZODIACLGALS1
Ontologies - Pathways
QuickGOP09382
Ontology : AmiGOplasma cell differentiation  RNA binding  protein binding  extracellular region  extracellular space  intracellular  nucleus  cytoplasm  endoplasmic reticulum lumen  cytosol  apoptotic process  cell surface  negative regulation of cell-substrate adhesion  negative regulation of neuron projection development  lactose binding  T cell costimulation  positive regulation of erythrocyte aggregation  response to isolation stress  response to drug  protein homodimerization activity  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  laminin binding  post-translational protein modification  cellular protein metabolic process  myoblast differentiation  positive regulation of viral entry into host cell  response to axon injury  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  cellular response to glucose stimulus  cellular response to organic cyclic compound  positive regulation of dendritic cell differentiation  
Ontology : EGO-EBIplasma cell differentiation  RNA binding  protein binding  extracellular region  extracellular space  intracellular  nucleus  cytoplasm  endoplasmic reticulum lumen  cytosol  apoptotic process  cell surface  negative regulation of cell-substrate adhesion  negative regulation of neuron projection development  lactose binding  T cell costimulation  positive regulation of erythrocyte aggregation  response to isolation stress  response to drug  protein homodimerization activity  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  laminin binding  post-translational protein modification  cellular protein metabolic process  myoblast differentiation  positive regulation of viral entry into host cell  response to axon injury  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  cellular response to glucose stimulus  cellular response to organic cyclic compound  positive regulation of dendritic cell differentiation  
NDEx NetworkLGALS1
Atlas of Cancer Signalling NetworkLGALS1
Wikipedia pathwaysLGALS1
Orthology - Evolution
OrthoDB3956
GeneTree (enSembl)ENSG00000100097
Phylogenetic Trees/Animal Genes : TreeFamLGALS1
HOVERGENP09382
HOGENOMP09382
Homologs : HomoloGeneLGALS1
Homology/Alignments : Family Browser (UCSC)LGALS1
Gene fusions - Rearrangements
Fusion PortalZ83844.2 LGALS1 22q13.1 BLCA
Fusion : QuiverLGALS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGALS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGALS1
dbVarLGALS1
ClinVarLGALS1
1000_GenomesLGALS1 
Exome Variant ServerLGALS1
ExAC (Exome Aggregation Consortium)ENSG00000100097
GNOMAD BrowserENSG00000100097
Varsome BrowserLGALS1
Genetic variants : HAPMAP3956
Genomic Variants (DGV)LGALS1 [DGVbeta]
DECIPHERLGALS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGALS1 
Mutations
ICGC Data PortalLGALS1 
TCGA Data PortalLGALS1 
Broad Tumor PortalLGALS1
OASIS PortalLGALS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGALS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGALS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGALS1
DgiDB (Drug Gene Interaction Database)LGALS1
DoCM (Curated mutations)LGALS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGALS1 (select a term)
intoGenLGALS1
Cancer3DLGALS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150570   
Orphanet
DisGeNETLGALS1
MedgenLGALS1
Genetic Testing Registry LGALS1
NextProtP09382 [Medical]
TSGene3956
GENETestsLGALS1
Target ValidationLGALS1
Huge Navigator LGALS1 [HugePedia]
snp3D : Map Gene to Disease3956
BioCentury BCIQLGALS1
ClinGenLGALS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3956
Chemical/Pharm GKB GenePA30337
Clinical trialLGALS1
Miscellaneous
canSAR (ICR)LGALS1 (select the gene name)
Probes
Litterature
PubMed389 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGALS1
EVEXLGALS1
GoPubMedLGALS1
iHOPLGALS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:10:54 CEST 2018
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