Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LGALS12 (galectin 12)

Identity

Alias_nameslectin
Alias_symbol (synonym)GRIP1
Other aliasGAL12
HGNC (Hugo) LGALS12
LocusID (NCBI) 85329
Atlas_Id 55659
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 63506052 and ends at 63516774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANXA7 (10q22.2) / LGALS12 (11q12.3)LGALS12 (11q12.3) / PLAC9 (10q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;11)(q22;q12) ANXA7/LGALS12
t(10;11)(q22;q12) LGALS12/PLAC9

External links

Nomenclature
HGNC (Hugo)LGALS12   15788
Cards
Entrez_Gene (NCBI)LGALS12  85329  galectin 12
AliasesGAL12; GRIP1
GeneCards (Weizmann)LGALS12
Ensembl hg19 (Hinxton)ENSG00000133317 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133317 [Gene_View]  ENSG00000133317 [Sequence]  chr11:63506052-63516774 [Contig_View]  LGALS12 [Vega]
ICGC DataPortalENSG00000133317
TCGA cBioPortalLGALS12
AceView (NCBI)LGALS12
Genatlas (Paris)LGALS12
WikiGenes85329
SOURCE (Princeton)LGALS12
Genetics Home Reference (NIH)LGALS12
Genomic and cartography
GoldenPath hg38 (UCSC)LGALS12  -     chr11:63506052-63516774 +  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGALS12  -     11q12.3   [Description]    (hg19-Feb_2009)
EnsemblLGALS12 - 11q12.3 [CytoView hg19]  LGALS12 - 11q12.3 [CytoView hg38]
Mapping of homologs : NCBILGALS12 [Mapview hg19]  LGALS12 [Mapview hg38]
OMIM606096   
Gene and transcription
Genbank (Entrez)AF222694 AF222695 AF244974 AF244975 AF244976
RefSeq transcript (Entrez)NM_001142535 NM_001142536 NM_001142537 NM_001142538 NM_033101
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGALS12
Cluster EST : UnigeneHs.502774 [ NCBI ]
CGAP (NCI)Hs.502774
Alternative Splicing GalleryENSG00000133317
Gene ExpressionLGALS12 [ NCBI-GEO ]   LGALS12 [ EBI - ARRAY_EXPRESS ]   LGALS12 [ SEEK ]   LGALS12 [ MEM ]
Gene Expression Viewer (FireBrowse)LGALS12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85329
GTEX Portal (Tissue expression)LGALS12
Human Protein AtlasENSG00000133317-LGALS12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DT0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96DT0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96DT0
Splice isoforms : SwissVarQ96DT0
PhosPhoSitePlusQ96DT0
Domaine pattern : Prosite (Expaxy)GALECTIN (PS51304)   
Domains : Interpro (EBI)ConA-like_dom_sf    Galectin_12    Galectin_CRD   
Domain families : Pfam (Sanger)Gal-bind_lectin (PF00337)   
Domain families : Pfam (NCBI)pfam00337   
Domain families : Smart (EMBL)Gal-bind_lectin (SM00908)  GLECT (SM00276)  
Conserved Domain (NCBI)LGALS12
DMDM Disease mutations85329
Blocks (Seattle)LGALS12
SuperfamilyQ96DT0
Human Protein Atlas [tissue]ENSG00000133317-LGALS12 [tissue]
Peptide AtlasQ96DT0
HPRD16196
IPIIPI00304389   IPI00220535   IPI00220536   IPI00220537   IPI00220538   IPI00010990   IPI00220539   
Protein Interaction databases
DIP (DOE-UCLA)Q96DT0
IntAct (EBI)Q96DT0
FunCoupENSG00000133317
BioGRIDLGALS12
STRING (EMBL)LGALS12
ZODIACLGALS12
Ontologies - Pathways
QuickGOQ96DT0
Ontology : AmiGOnucleus  mitochondrion  lactose binding  regulation of fat cell differentiation  regulation of lipid catabolic process  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBInucleus  mitochondrion  lactose binding  regulation of fat cell differentiation  regulation of lipid catabolic process  intrinsic apoptotic signaling pathway  
NDEx NetworkLGALS12
Atlas of Cancer Signalling NetworkLGALS12
Wikipedia pathwaysLGALS12
Orthology - Evolution
OrthoDB85329
GeneTree (enSembl)ENSG00000133317
Phylogenetic Trees/Animal Genes : TreeFamLGALS12
HOVERGENQ96DT0
HOGENOMQ96DT0
Homologs : HomoloGeneLGALS12
Homology/Alignments : Family Browser (UCSC)LGALS12
Gene fusions - Rearrangements
Fusion : QuiverLGALS12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGALS12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGALS12
dbVarLGALS12
ClinVarLGALS12
1000_GenomesLGALS12 
Exome Variant ServerLGALS12
ExAC (Exome Aggregation Consortium)ENSG00000133317
GNOMAD BrowserENSG00000133317
Varsome BrowserLGALS12
Genetic variants : HAPMAP85329
Genomic Variants (DGV)LGALS12 [DGVbeta]
DECIPHERLGALS12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGALS12 
Mutations
ICGC Data PortalLGALS12 
TCGA Data PortalLGALS12 
Broad Tumor PortalLGALS12
OASIS PortalLGALS12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGALS12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGALS12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGALS12
DgiDB (Drug Gene Interaction Database)LGALS12
DoCM (Curated mutations)LGALS12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGALS12 (select a term)
intoGenLGALS12
Cancer3DLGALS12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606096   
Orphanet
DisGeNETLGALS12
MedgenLGALS12
Genetic Testing Registry LGALS12
NextProtQ96DT0 [Medical]
TSGene85329
GENETestsLGALS12
Target ValidationLGALS12
Huge Navigator LGALS12 [HugePedia]
snp3D : Map Gene to Disease85329
BioCentury BCIQLGALS12
ClinGenLGALS12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85329
Chemical/Pharm GKB GenePA30338
Clinical trialLGALS12
Miscellaneous
canSAR (ICR)LGALS12 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGALS12
EVEXLGALS12
GoPubMedLGALS12
iHOPLGALS12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:31:46 CEST 2018
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