Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LGALS3BP (galectin 3 binding protein)

Identity

Alias_nameslectin
Alias_symbol (synonym)MAC-2-BP
90K
BTBD17B
TANGO10B
M2BP
gp90
CyCAP
Other alias
HGNC (Hugo) LGALS3BP
LocusID (NCBI) 3959
Atlas_Id 41143
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78971253 and ends at 78979979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FOS (14q24.3) / LGALS3BP (17q25.3)LGALS3BP (17q25.3) / CYTH1 (17q25.3)LGALS3BP (17q25.3) / DCBLD2 (3q12.1)
LGALS3BP (17q25.3) / ELK3 (12q23.1)LGALS3BP (17q25.3) / LGALS3BP (17q25.3)VCP (9p13.3) / LGALS3BP (17q25.3)
XPC (3p25.1) / LGALS3BP (17q25.3)LGALS3BP 17q25.3 / DCBLD2 3q12.1LGALS3BP 17q25.3 / ELK3 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;17)(q12;q25) LGALS3BP/DCBLD2
t(12;17)(q23;q25) LGALS3BP/ELK3

External links

Nomenclature
HGNC (Hugo)LGALS3BP   6564
Cards
Entrez_Gene (NCBI)LGALS3BP  3959  galectin 3 binding protein
Aliases90K; BTBD17B; CyCAP; M2BP; 
MAC-2-BP; TANGO10B; gp90
GeneCards (Weizmann)LGALS3BP
Ensembl hg19 (Hinxton)ENSG00000108679 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108679 [Gene_View]  ENSG00000108679 [Sequence]  chr17:78971253-78979979 [Contig_View]  LGALS3BP [Vega]
ICGC DataPortalENSG00000108679
TCGA cBioPortalLGALS3BP
AceView (NCBI)LGALS3BP
Genatlas (Paris)LGALS3BP
WikiGenes3959
SOURCE (Princeton)LGALS3BP
Genetics Home Reference (NIH)LGALS3BP
Genomic and cartography
GoldenPath hg38 (UCSC)LGALS3BP  -     chr17:78971253-78979979 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGALS3BP  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblLGALS3BP - 17q25.3 [CytoView hg19]  LGALS3BP - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBILGALS3BP [Mapview hg19]  LGALS3BP [Mapview hg38]
OMIM600626   
Gene and transcription
Genbank (Entrez)AK055977 AK057776 AK293183 AK295442 AK301040
RefSeq transcript (Entrez)NM_005567
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGALS3BP
Cluster EST : UnigeneHs.514535 [ NCBI ]
CGAP (NCI)Hs.514535
Alternative Splicing GalleryENSG00000108679
Gene ExpressionLGALS3BP [ NCBI-GEO ]   LGALS3BP [ EBI - ARRAY_EXPRESS ]   LGALS3BP [ SEEK ]   LGALS3BP [ MEM ]
Gene Expression Viewer (FireBrowse)LGALS3BP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3959
GTEX Portal (Tissue expression)LGALS3BP
Human Protein AtlasENSG00000108679-LGALS3BP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08380   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08380  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08380
Splice isoforms : SwissVarQ08380
PhosPhoSitePlusQ08380
Domaine pattern : Prosite (Expaxy)BTB (PS50097)    SRCR_1 (PS00420)    SRCR_2 (PS50287)   
Domains : Interpro (EBI)BACK    BTB/POZ_dom    SRCR    SRCR-like_dom    SRCR-like_dom_sf   
Domain families : Pfam (Sanger)BACK (PF07707)    SRCR (PF00530)   
Domain families : Pfam (NCBI)pfam07707    pfam00530   
Domain families : Smart (EMBL)BACK (SM00875)  SR (SM00202)  
Conserved Domain (NCBI)LGALS3BP
DMDM Disease mutations3959
Blocks (Seattle)LGALS3BP
PDB (SRS)1BY2   
PDB (PDBSum)1BY2   
PDB (IMB)1BY2   
PDB (RSDB)1BY2   
Structural Biology KnowledgeBase1BY2   
SCOP (Structural Classification of Proteins)1BY2   
CATH (Classification of proteins structures)1BY2   
SuperfamilyQ08380
Human Protein Atlas [tissue]ENSG00000108679-LGALS3BP [tissue]
Peptide AtlasQ08380
HPRD02796
IPIIPI00023673   IPI00902654   IPI00908762   IPI01010990   
Protein Interaction databases
DIP (DOE-UCLA)Q08380
IntAct (EBI)Q08380
FunCoupENSG00000108679
BioGRIDLGALS3BP
STRING (EMBL)LGALS3BP
ZODIACLGALS3BP
Ontologies - Pathways
QuickGOQ08380
Ontology : AmiGOplatelet degranulation  scavenger receptor activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  receptor-mediated endocytosis  cellular defense response  cell adhesion  signal transduction  membrane  platelet dense granule lumen  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  
Ontology : EGO-EBIplatelet degranulation  scavenger receptor activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  receptor-mediated endocytosis  cellular defense response  cell adhesion  signal transduction  membrane  platelet dense granule lumen  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  
NDEx NetworkLGALS3BP
Atlas of Cancer Signalling NetworkLGALS3BP
Wikipedia pathwaysLGALS3BP
Orthology - Evolution
OrthoDB3959
GeneTree (enSembl)ENSG00000108679
Phylogenetic Trees/Animal Genes : TreeFamLGALS3BP
HOVERGENQ08380
HOGENOMQ08380
Homologs : HomoloGeneLGALS3BP
Homology/Alignments : Family Browser (UCSC)LGALS3BP
Gene fusions - Rearrangements
Fusion : MitelmanLGALS3BP/DCBLD2 [17q25.3/3q12.1]  
Fusion : MitelmanLGALS3BP/ELK3 [17q25.3/12q23.1]  [t(12;17)(q23;q25)]  
Fusion PortalLGALS3BP 17q25.3 DCBLD2 3q12.1 SKCM
Fusion PortalLGALS3BP 17q25.3 ELK3 12q23.1 LUAD
Fusion : QuiverLGALS3BP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGALS3BP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGALS3BP
dbVarLGALS3BP
ClinVarLGALS3BP
1000_GenomesLGALS3BP 
Exome Variant ServerLGALS3BP
ExAC (Exome Aggregation Consortium)ENSG00000108679
GNOMAD BrowserENSG00000108679
Varsome BrowserLGALS3BP
Genetic variants : HAPMAP3959
Genomic Variants (DGV)LGALS3BP [DGVbeta]
DECIPHERLGALS3BP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGALS3BP 
Mutations
ICGC Data PortalLGALS3BP 
TCGA Data PortalLGALS3BP 
Broad Tumor PortalLGALS3BP
OASIS PortalLGALS3BP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGALS3BP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGALS3BP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGALS3BP
DgiDB (Drug Gene Interaction Database)LGALS3BP
DoCM (Curated mutations)LGALS3BP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGALS3BP (select a term)
intoGenLGALS3BP
Cancer3DLGALS3BP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600626   
Orphanet
DisGeNETLGALS3BP
MedgenLGALS3BP
Genetic Testing Registry LGALS3BP
NextProtQ08380 [Medical]
TSGene3959
GENETestsLGALS3BP
Target ValidationLGALS3BP
Huge Navigator LGALS3BP [HugePedia]
snp3D : Map Gene to Disease3959
BioCentury BCIQLGALS3BP
ClinGenLGALS3BP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3959
Chemical/Pharm GKB GenePA30341
Clinical trialLGALS3BP
Miscellaneous
canSAR (ICR)LGALS3BP (select the gene name)
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGALS3BP
EVEXLGALS3BP
GoPubMedLGALS3BP
iHOPLGALS3BP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:16:16 CET 2018
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