LGALS4 (galectin 4)

2003-06-01  

Identity

HGNC
LGALS4
LOCATION
19q13.2
LOCUSID
3960
ALIAS
GAL4,L36LBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3960
MIM: 602518
HGNC: 6565
Ensembl: ENSG00000171747

Variants:

dbSNP: 3960
ClinVar: 3960
TCGA: ENSG00000171747
COSMIC: LGALS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171747ENST00000307751P56470
ENSG00000171747ENST00000307751Q6FHZ4
ENSG00000171747ENST00000594209M0R349
ENSG00000171747ENST00000595291M0R1B2
ENSG00000171747ENST00000600070M0QZ93

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158831992005Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.64
169404232007Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.42
191922492009Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells.37
210641092011Galectin-4 functions as a tumor suppressor of human colorectal cancer.28
119718642002High-affinity binding of recombinant human galectin-4 to SO(3)(-)-->3Galbeta1-->3GalNAc pyranoside.21
261732572015Assembly, organization and regulation of cell-surface receptors by lectin-glycan complexes.19
217241802011Galectins distinctively regulate central monocyte and macrophage function.18
275908972017Tissue- and cell-specific localization of galectins, β-galactose-binding animal lectins, and their potential functions in health and disease.16
155468742005Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells.15
252301112014Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinoma.15

Citation

Dessen P

LGALS4 (galectin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41144/lgals4