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LGALS8 (galectin 8)

Identity

Alias_nameslectin
Alias_symbol (synonym)PCTA-1
Other aliasGal-8
PCTA1
Po66-CBP
HGNC (Hugo) LGALS8
LocusID (NCBI) 3964
Atlas_Id 41146
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 236518214 and ends at 236552979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LGALS8 (1q43) / EDARADD (1q42.3)LGALS8 (1q43) / LGALS8 (1q43)LGALS8 (1q43) / RHBG (1q22)
LGALS8 (1q43) / TRIM67 (1q42.2)LGALS8 (1q43) / WAC (10p12.1)RELL1 (4p14) / LGALS8 (1q43)
LGALS8 1q43 / EDARADD 1q42.3LGALS8 1q43 / RHBG 1q22LGALS8 1q43 / TRIM67 1q42.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(q42;q43) LGALS8/EDARADD
t(1;1)(q42;q43) LGALS8/TRIM67


External links

Nomenclature
HGNC (Hugo)LGALS8   6569
Cards
Entrez_Gene (NCBI)LGALS8  3964  galectin 8
AliasesGal-8; PCTA-1; PCTA1; Po66-CBP
GeneCards (Weizmann)LGALS8
Ensembl hg19 (Hinxton)ENSG00000116977 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116977 [Gene_View]  ENSG00000116977 [Sequence]  chr1:236518214-236552979 [Contig_View]  LGALS8 [Vega]
ICGC DataPortalENSG00000116977
TCGA cBioPortalLGALS8
AceView (NCBI)LGALS8
Genatlas (Paris)LGALS8
WikiGenes3964
SOURCE (Princeton)LGALS8
Genetics Home Reference (NIH)LGALS8
Genomic and cartography
GoldenPath hg38 (UCSC)LGALS8  -     chr1:236518214-236552979 +  1q43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGALS8  -     1q43   [Description]    (hg19-Feb_2009)
EnsemblLGALS8 - 1q43 [CytoView hg19]  LGALS8 - 1q43 [CytoView hg38]
Mapping of homologs : NCBILGALS8 [Mapview hg19]  LGALS8 [Mapview hg38]
OMIM606099   
Gene and transcription
Genbank (Entrez)AB209914 AF074000 AF074001 AF074002 AF342815
RefSeq transcript (Entrez)NM_006499 NM_201543 NM_201544 NM_201545
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGALS8
Cluster EST : UnigeneHs.735982 [ NCBI ]
CGAP (NCI)Hs.735982
Alternative Splicing GalleryENSG00000116977
Gene ExpressionLGALS8 [ NCBI-GEO ]   LGALS8 [ EBI - ARRAY_EXPRESS ]   LGALS8 [ SEEK ]   LGALS8 [ MEM ]
Gene Expression Viewer (FireBrowse)LGALS8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3964
GTEX Portal (Tissue expression)LGALS8
Human Protein AtlasENSG00000116977-LGALS8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00214   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00214  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00214
Splice isoforms : SwissVarO00214
PhosPhoSitePlusO00214
Domaine pattern : Prosite (Expaxy)GALECTIN (PS51304)   
Domains : Interpro (EBI)ConA-like_dom_sf    Galectin_8    Galectin_CRD   
Domain families : Pfam (Sanger)Gal-bind_lectin (PF00337)   
Domain families : Pfam (NCBI)pfam00337   
Domain families : Smart (EMBL)Gal-bind_lectin (SM00908)  GLECT (SM00276)  
Conserved Domain (NCBI)LGALS8
DMDM Disease mutations3964
Blocks (Seattle)LGALS8
PDB (SRS)2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
PDB (PDBSum)2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
PDB (IMB)2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
PDB (RSDB)2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
Structural Biology KnowledgeBase2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
SCOP (Structural Classification of Proteins)2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
CATH (Classification of proteins structures)2YRO    2YV8    2YXS    3AP4    3AP5    3AP6    3AP7    3AP9    3APB    3OJB    3VKL    3VKM    3VKN    3VKO    4BMB    4BME    4FQZ    4GXL    4HAN    5GZC    5GZD    5GZE    5GZF    5GZG    5T7I    5T7S    5T7T    5T7U   
SuperfamilyO00214
Human Protein Atlas [tissue]ENSG00000116977-LGALS8 [tissue]
Peptide AtlasO00214
HPRD09356
IPIIPI00010844   IPI00165587   IPI00909243   IPI00874257   IPI00479062   IPI00646437   IPI00644218   IPI00983338   IPI00974239   IPI00940092   IPI00980034   IPI00984601   IPI00974503   IPI00382683   
Protein Interaction databases
DIP (DOE-UCLA)O00214
IntAct (EBI)O00214
FunCoupENSG00000116977
BioGRIDLGALS8
STRING (EMBL)LGALS8
ZODIACLGALS8
Ontologies - Pathways
QuickGOO00214
Ontology : AmiGOintegrin binding  protein binding  extracellular space  cytoplasm  cytosol  membrane  carbohydrate binding  cytoplasmic vesicle  cellular response to virus  xenophagy  lymphatic endothelial cell migration  
Ontology : EGO-EBIintegrin binding  protein binding  extracellular space  cytoplasm  cytosol  membrane  carbohydrate binding  cytoplasmic vesicle  cellular response to virus  xenophagy  lymphatic endothelial cell migration  
NDEx NetworkLGALS8
Atlas of Cancer Signalling NetworkLGALS8
Wikipedia pathwaysLGALS8
Orthology - Evolution
OrthoDB3964
GeneTree (enSembl)ENSG00000116977
Phylogenetic Trees/Animal Genes : TreeFamLGALS8
HOVERGENO00214
HOGENOMO00214
Homologs : HomoloGeneLGALS8
Homology/Alignments : Family Browser (UCSC)LGALS8
Gene fusions - Rearrangements
Fusion : MitelmanLGALS8/EDARADD [1q43/1q42.3]  
Fusion : MitelmanLGALS8/TRIM67 [1q43/1q42.2]  [t(1;1)(q42;q43)]  
Fusion PortalLGALS8 1q43 EDARADD 1q42.3 BRCA
Fusion PortalLGALS8 1q43 RHBG 1q22 BLCA
Fusion PortalLGALS8 1q43 TRIM67 1q42.2 BRCA
Fusion : QuiverLGALS8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGALS8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGALS8
dbVarLGALS8
ClinVarLGALS8
1000_GenomesLGALS8 
Exome Variant ServerLGALS8
ExAC (Exome Aggregation Consortium)ENSG00000116977
GNOMAD BrowserENSG00000116977
Varsome BrowserLGALS8
Genetic variants : HAPMAP3964
Genomic Variants (DGV)LGALS8 [DGVbeta]
DECIPHERLGALS8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGALS8 
Mutations
ICGC Data PortalLGALS8 
TCGA Data PortalLGALS8 
Broad Tumor PortalLGALS8
OASIS PortalLGALS8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGALS8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGALS8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGALS8
DgiDB (Drug Gene Interaction Database)LGALS8
DoCM (Curated mutations)LGALS8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGALS8 (select a term)
intoGenLGALS8
Cancer3DLGALS8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606099   
Orphanet
DisGeNETLGALS8
MedgenLGALS8
Genetic Testing Registry LGALS8
NextProtO00214 [Medical]
TSGene3964
GENETestsLGALS8
Target ValidationLGALS8
Huge Navigator LGALS8 [HugePedia]
snp3D : Map Gene to Disease3964
BioCentury BCIQLGALS8
ClinGenLGALS8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3964
Chemical/Pharm GKB GenePA30346
Clinical trialLGALS8
Miscellaneous
canSAR (ICR)LGALS8 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGALS8
EVEXLGALS8
GoPubMedLGALS8
iHOPLGALS8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:31:49 CEST 2018

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