Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LGALS9 (galectin 9)

Identity

Alias_nameslectin
Alias_symbol (synonym)LGALS9A
Other aliasHUAT
HGNC (Hugo) LGALS9
LocusID (NCBI) 3965
Atlas_Id 41147
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 27631148 and ends at 27649560 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KSR1 (17q11.1) / LGALS9 (17q11.2)LGALS9 (17q11.2) / LGALS9B (17p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LGALS9   6570
Cards
Entrez_Gene (NCBI)LGALS9  3965  galectin 9
AliasesHUAT; LGALS9A
GeneCards (Weizmann)LGALS9
Ensembl hg19 (Hinxton)ENSG00000168961 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168961 [Gene_View]  chr17:27631148-27649560 [Contig_View]  LGALS9 [Vega]
ICGC DataPortalENSG00000168961
TCGA cBioPortalLGALS9
AceView (NCBI)LGALS9
Genatlas (Paris)LGALS9
WikiGenes3965
SOURCE (Princeton)LGALS9
Genetics Home Reference (NIH)LGALS9
Genomic and cartography
GoldenPath hg38 (UCSC)LGALS9  -     chr17:27631148-27649560 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGALS9  -     17q11.2   [Description]    (hg19-Feb_2009)
EnsemblLGALS9 - 17q11.2 [CytoView hg19]  LGALS9 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBILGALS9 [Mapview hg19]  LGALS9 [Mapview hg38]
OMIM601879   
Gene and transcription
Genbank (Entrez)AB003517 AB005894 AB006782 AB008492 AK126017
RefSeq transcript (Entrez)NM_001330163 NM_002308 NM_009587
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGALS9
Cluster EST : UnigeneHs.81337 [ NCBI ]
CGAP (NCI)Hs.81337
Alternative Splicing GalleryENSG00000168961
Gene ExpressionLGALS9 [ NCBI-GEO ]   LGALS9 [ EBI - ARRAY_EXPRESS ]   LGALS9 [ SEEK ]   LGALS9 [ MEM ]
Gene Expression Viewer (FireBrowse)LGALS9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3965
GTEX Portal (Tissue expression)LGALS9
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00182   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00182  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00182
Splice isoforms : SwissVarO00182
PhosPhoSitePlusO00182
Domaine pattern : Prosite (Expaxy)GALECTIN (PS51304)   
Domains : Interpro (EBI)ConA-like_dom    Galectin_CRD   
Domain families : Pfam (Sanger)Gal-bind_lectin (PF00337)   
Domain families : Pfam (NCBI)pfam00337   
Domain families : Smart (EMBL)Gal-bind_lectin (SM00908)  GLECT (SM00276)  
Conserved Domain (NCBI)LGALS9
DMDM Disease mutations3965
Blocks (Seattle)LGALS9
PDB (SRS)2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
PDB (PDBSum)2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
PDB (IMB)2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
PDB (RSDB)2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
Structural Biology KnowledgeBase2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
SCOP (Structural Classification of Proteins)2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
CATH (Classification of proteins structures)2EAK    2EAL    2YY1    2ZHK    2ZHL    2ZHM    2ZHN    3LSD    3LSE    3NV1    3NV2    3NV3    3NV4    3WLU    3WV6   
SuperfamilyO00182
Human Protein AtlasENSG00000168961
Peptide AtlasO00182
HPRD03528
IPIIPI00010477   IPI00293267   IPI00908681   IPI00163684   IPI00788674   IPI00789269   
Protein Interaction databases
DIP (DOE-UCLA)O00182
IntAct (EBI)O00182
FunCoupENSG00000168961
BioGRIDLGALS9
STRING (EMBL)LGALS9
ZODIACLGALS9
Ontologies - Pathways
QuickGOO00182
Ontology : AmiGOnatural killer cell tolerance induction  signal transducer activity  galactose binding  extracellular space  intracellular  nucleus  cytoplasm  cytosol  chemotaxis  inflammatory response  female pregnancy  positive regulation of gene expression  negative regulation of gene expression  negative regulation of gene expression  enzyme binding  carbohydrate binding  response to lipopolysaccharide  regulation of interleukin-4 production  regulation of interleukin-5 production  negative regulation of chemokine production  negative regulation of interferon-gamma production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-4 production  positive regulation of interleukin-4 production  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  p38MAPK cascade  positive regulation of NF-kappaB import into nucleus  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of mast cell degranulation  negative regulation of natural killer cell mediated cytotoxicity  negative regulation of activated T cell proliferation  positive regulation of viral entry into host cell  disaccharide binding  positive regulation of interleukin-1 beta secretion  positive regulation of NF-kappaB transcription factor activity  maternal process involved in female pregnancy  extracellular exosome  positive regulation of activated T cell autonomous cell death  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  cellular response to interferon-gamma  positive regulation of transforming growth factor beta production  positive regulation of monocyte chemotactic protein-1 production  mature conventional dendritic cell differentiation  cellular response to virus  regulation of p38MAPK cascade  positive regulation of interferon-gamma secretion  positive regulation of tumor necrosis factor secretion  positive regulation of interleukin-8 secretion  positive regulation of dendritic cell chemotaxis  negative regulation of CD4-positive, alpha-beta T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell proliferation  positive regulation of interleukin-13 secretion  positive regulation of dendritic cell apoptotic process  positive regulation of interleukin-6 secretion  positive regulation of interleukin-10 secretion  positive regulation of interleukin-12 secretion  positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  positive regulation of dendritic cell differentiation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Ontology : EGO-EBInatural killer cell tolerance induction  signal transducer activity  galactose binding  extracellular space  intracellular  nucleus  cytoplasm  cytosol  chemotaxis  inflammatory response  female pregnancy  positive regulation of gene expression  negative regulation of gene expression  negative regulation of gene expression  enzyme binding  carbohydrate binding  response to lipopolysaccharide  regulation of interleukin-4 production  regulation of interleukin-5 production  negative regulation of chemokine production  negative regulation of interferon-gamma production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-4 production  positive regulation of interleukin-4 production  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  p38MAPK cascade  positive regulation of NF-kappaB import into nucleus  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of mast cell degranulation  negative regulation of natural killer cell mediated cytotoxicity  negative regulation of activated T cell proliferation  positive regulation of viral entry into host cell  disaccharide binding  positive regulation of interleukin-1 beta secretion  positive regulation of NF-kappaB transcription factor activity  maternal process involved in female pregnancy  extracellular exosome  positive regulation of activated T cell autonomous cell death  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  cellular response to interferon-gamma  positive regulation of transforming growth factor beta production  positive regulation of monocyte chemotactic protein-1 production  mature conventional dendritic cell differentiation  cellular response to virus  regulation of p38MAPK cascade  positive regulation of interferon-gamma secretion  positive regulation of tumor necrosis factor secretion  positive regulation of interleukin-8 secretion  positive regulation of dendritic cell chemotaxis  negative regulation of CD4-positive, alpha-beta T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell proliferation  positive regulation of interleukin-13 secretion  positive regulation of dendritic cell apoptotic process  positive regulation of interleukin-6 secretion  positive regulation of interleukin-10 secretion  positive regulation of interleukin-12 secretion  positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  positive regulation of dendritic cell differentiation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
NDEx NetworkLGALS9
Atlas of Cancer Signalling NetworkLGALS9
Wikipedia pathwaysLGALS9
Orthology - Evolution
OrthoDB3965
GeneTree (enSembl)ENSG00000168961
Phylogenetic Trees/Animal Genes : TreeFamLGALS9
HOVERGENO00182
HOGENOMO00182
Homologs : HomoloGeneLGALS9
Homology/Alignments : Family Browser (UCSC)LGALS9
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGALS9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGALS9
dbVarLGALS9
ClinVarLGALS9
1000_GenomesLGALS9 
Exome Variant ServerLGALS9
ExAC (Exome Aggregation Consortium)LGALS9 (select the gene name)
Genetic variants : HAPMAP3965
Genomic Variants (DGV)LGALS9 [DGVbeta]
DECIPHERLGALS9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGALS9 
Mutations
ICGC Data PortalLGALS9 
TCGA Data PortalLGALS9 
Broad Tumor PortalLGALS9
OASIS PortalLGALS9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGALS9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGALS9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGALS9
DgiDB (Drug Gene Interaction Database)LGALS9
DoCM (Curated mutations)LGALS9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGALS9 (select a term)
intoGenLGALS9
Cancer3DLGALS9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601879   
Orphanet
MedgenLGALS9
Genetic Testing Registry LGALS9
NextProtO00182 [Medical]
TSGene3965
GENETestsLGALS9
Target ValidationLGALS9
Huge Navigator LGALS9 [HugePedia]
snp3D : Map Gene to Disease3965
BioCentury BCIQLGALS9
ClinGenLGALS9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3965
Chemical/Pharm GKB GenePA30347
Clinical trialLGALS9
Miscellaneous
canSAR (ICR)LGALS9 (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGALS9
EVEXLGALS9
GoPubMedLGALS9
iHOPLGALS9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:05:13 CEST 2017

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