LGALS9 (galectin 9)

2003-06-01  

Identity

HGNC
LGALS9
LOCATION
17q11.2
LOCUSID
3965
ALIAS
HUAT,LGALS9A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3965
MIM: 601879
HGNC: 6570
Ensembl: ENSG00000168961

Variants:

dbSNP: 3965
ClinVar: 3965
TCGA: ENSG00000168961
COSMIC: LGALS9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168961ENST00000302228O00182
ENSG00000168961ENST00000302228A0A024QZ02
ENSG00000168961ENST00000313648O00182
ENSG00000168961ENST00000395473O00182
ENSG00000168961ENST00000395473A0A024QZ55
ENSG00000168961ENST00000467111J3QKK6
ENSG00000168961ENST00000577392J3KS82
ENSG00000168961ENST00000578944J3QS92
ENSG00000168961ENST00000580779J3QKK6
ENSG00000168961ENST00000581710J3KSA0
ENSG00000168961ENST00000584661K7EPS0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190051812009Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells.133
225052392012Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.120
223234532012Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9.106
205740072010Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells.79
216703072011Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.79
126466272003Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway.78
202090972010A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.78
171564392006Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9.71
170697542006A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9.59
174463362007Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma.53

Citation

Dessen P

LGALS9 (galectin 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41147/lgals9