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LGI4 (leucine rich repeat LGI family member 4)

Identity

Alias_namesleucine-rich repeat LGI family
Other aliasLGIL3
HGNC (Hugo) LGI4
LocusID (NCBI) 163175
Atlas_Id 55267
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35124513 and ends at 35135274 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AC020907.3 () / LGI4 (19q13.12)LGI4 (19q13.12) / MYH10 (17p13.1)LGI4 (19q13.12) / PROX1-AS1 (1q32.3)
MGMT (10q26.3) / LGI4 (19q13.12)AC020907.3 LGI4 19q13.12MGMT 10q26.3 / LGI4 19q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LGI4   18712
Cards
Entrez_Gene (NCBI)LGI4  163175  leucine rich repeat LGI family member 4
AliasesLGIL3
GeneCards (Weizmann)LGI4
Ensembl hg19 (Hinxton)ENSG00000153902 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153902 [Gene_View]  chr19:35124513-35135274 [Contig_View]  LGI4 [Vega]
ICGC DataPortalENSG00000153902
TCGA cBioPortalLGI4
AceView (NCBI)LGI4
Genatlas (Paris)LGI4
WikiGenes163175
SOURCE (Princeton)LGI4
Genetics Home Reference (NIH)LGI4
Genomic and cartography
GoldenPath hg38 (UCSC)LGI4  -     chr19:35124513-35135274 -  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGI4  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblLGI4 - 19q13.12 [CytoView hg19]  LGI4 - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBILGI4 [Mapview hg19]  LGI4 [Mapview hg38]
OMIM608303   
Gene and transcription
Genbank (Entrez)AF467954 AJ487519 AJ487959 AL832968 AY358121
RefSeq transcript (Entrez)NM_139284
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGI4
Cluster EST : UnigeneHs.65256 [ NCBI ]
CGAP (NCI)Hs.65256
Alternative Splicing GalleryENSG00000153902
Gene ExpressionLGI4 [ NCBI-GEO ]   LGI4 [ EBI - ARRAY_EXPRESS ]   LGI4 [ SEEK ]   LGI4 [ MEM ]
Gene Expression Viewer (FireBrowse)LGI4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)163175
GTEX Portal (Tissue expression)LGI4
Human Protein AtlasENSG00000153902-LGI4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N135   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N135  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N135
Splice isoforms : SwissVarQ8N135
PhosPhoSitePlusQ8N135
Domaine pattern : Prosite (Expaxy)EAR (PS50912)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    EAR    EPTP    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)EPTP (PF03736)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam03736    pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  
Conserved Domain (NCBI)LGI4
DMDM Disease mutations163175
Blocks (Seattle)LGI4
SuperfamilyQ8N135
Human Protein Atlas [tissue]ENSG00000153902-LGI4 [tissue]
Peptide AtlasQ8N135
HPRD06433
IPIIPI00166060   IPI00397585   IPI01014351   IPI00790367   
Protein Interaction databases
DIP (DOE-UCLA)Q8N135
IntAct (EBI)Q8N135
FunCoupENSG00000153902
BioGRIDLGI4
STRING (EMBL)LGI4
ZODIACLGI4
Ontologies - Pathways
QuickGOQ8N135
Ontology : AmiGOextracellular region  extracellular space  adult locomotory behavior  glial cell proliferation  myelination in peripheral nervous system  neuron maturation  
Ontology : EGO-EBIextracellular region  extracellular space  adult locomotory behavior  glial cell proliferation  myelination in peripheral nervous system  neuron maturation  
NDEx NetworkLGI4
Atlas of Cancer Signalling NetworkLGI4
Wikipedia pathwaysLGI4
Orthology - Evolution
OrthoDB163175
GeneTree (enSembl)ENSG00000153902
Phylogenetic Trees/Animal Genes : TreeFamLGI4
HOVERGENQ8N135
HOGENOMQ8N135
Homologs : HomoloGeneLGI4
Homology/Alignments : Family Browser (UCSC)LGI4
Gene fusions - Rearrangements
Fusion : MitelmanMGMT/LGI4 [10q26.3/19q13.12]  [t(10;19)(q26;q13)]  
Fusion: TCGA_MDACCAC020907.3 LGI4 19q13.12 SKCM
Fusion: TCGA_MDACCMGMT 10q26.3 LGI4 19q13.12 BRCA
Tumor Fusion PortalLGI4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGI4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGI4
dbVarLGI4
ClinVarLGI4
1000_GenomesLGI4 
Exome Variant ServerLGI4
ExAC (Exome Aggregation Consortium)ENSG00000153902
GNOMAD BrowserENSG00000153902
Genetic variants : HAPMAP163175
Genomic Variants (DGV)LGI4 [DGVbeta]
DECIPHERLGI4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGI4 
Mutations
ICGC Data PortalLGI4 
TCGA Data PortalLGI4 
Broad Tumor PortalLGI4
OASIS PortalLGI4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGI4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGI4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGI4
DgiDB (Drug Gene Interaction Database)LGI4
DoCM (Curated mutations)LGI4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGI4 (select a term)
intoGenLGI4
Cancer3DLGI4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608303   
Orphanet
DisGeNETLGI4
MedgenLGI4
Genetic Testing Registry LGI4
NextProtQ8N135 [Medical]
TSGene163175
GENETestsLGI4
Target ValidationLGI4
Huge Navigator LGI4 [HugePedia]
snp3D : Map Gene to Disease163175
BioCentury BCIQLGI4
ClinGenLGI4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD163175
Chemical/Pharm GKB GenePA38656
Clinical trialLGI4
Miscellaneous
canSAR (ICR)LGI4 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGI4
EVEXLGI4
GoPubMedLGI4
iHOPLGI4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:47 CET 2017

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