LGR6 (leucine rich repeat containing G protein-coupled receptor 6)

2017-08-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
GPCR,VTS20631
FUSION GENES

Other Information

Locus ID:

NCBI: 59352
MIM: 606653
HGNC: 19719
Ensembl: ENSG00000133067

Variants:

dbSNP: 59352
ClinVar: 59352
TCGA: ENSG00000133067
COSMIC: LGR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133067ENST00000255432Q9HBX8
ENSG00000133067ENST00000367278Q9HBX8
ENSG00000133067ENST00000423542Q5T508
ENSG00000133067ENST00000439764Q9HBX8
ENSG00000133067ENST00000487787D6R9F0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226159202012LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.47
277986042016Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.19
280052672017Human gingiva transcriptome during wound healing.6
296255282018Down-regulation of LGR6 promotes bone fracture recovery using bone marrow stromal cells.2
316577862019Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.2
296931562018Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer.1
299716392019G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma.1
280132222017Generation and characterization of monoclonal antibodies against human LGR6.0

Citation

Dessen P

LGR6 (leucine rich repeat containing G protein-coupled receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57032/lgr6