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LGSN (lengsin, lens protein with glutamine synthetase domain)

Identity

Alias_namesGLULD1
glutamate-ammonia ligase (glutamine synthetase) domain containing 1
Alias_symbol (synonym)LGS
Other alias
HGNC (Hugo) LGSN
LocusID (NCBI) 51557
Atlas_Id 51123
Location 6q12  [Link to chromosome band 6q12]
Location_base_pair Starts at 63275951 and ends at 63319977 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LMBRD1 (6q13) / LGSN (6q12)LMBRD1 6q13 / LGSN 6q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LGSN   21016
Cards
Entrez_Gene (NCBI)LGSN  51557  lengsin, lens protein with glutamine synthetase domain
AliasesGLULD1; LGS
GeneCards (Weizmann)LGSN
Ensembl hg19 (Hinxton)ENSG00000146166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146166 [Gene_View]  ENSG00000146166 [Sequence]  chr6:63275951-63319977 [Contig_View]  LGSN [Vega]
ICGC DataPortalENSG00000146166
TCGA cBioPortalLGSN
AceView (NCBI)LGSN
Genatlas (Paris)LGSN
WikiGenes51557
SOURCE (Princeton)LGSN
Genetics Home Reference (NIH)LGSN
Genomic and cartography
GoldenPath hg38 (UCSC)LGSN  -     chr6:63275951-63319977 -  6q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LGSN  -     6q12   [Description]    (hg19-Feb_2009)
EnsemblLGSN - 6q12 [CytoView hg19]  LGSN - 6q12 [CytoView hg38]
Mapping of homologs : NCBILGSN [Mapview hg19]  LGSN [Mapview hg38]
OMIM611470   
Gene and transcription
Genbank (Entrez)AF242388 BC130366 BC130368 DQ682605 DQ682606
RefSeq transcript (Entrez)NM_001143940 NM_016571
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LGSN
Cluster EST : UnigeneHs.149585 [ NCBI ]
CGAP (NCI)Hs.149585
Alternative Splicing GalleryENSG00000146166
Gene ExpressionLGSN [ NCBI-GEO ]   LGSN [ EBI - ARRAY_EXPRESS ]   LGSN [ SEEK ]   LGSN [ MEM ]
Gene Expression Viewer (FireBrowse)LGSN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51557
GTEX Portal (Tissue expression)LGSN
Human Protein AtlasENSG00000146166-LGSN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TDP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TDP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TDP6
Splice isoforms : SwissVarQ5TDP6
PhosPhoSitePlusQ5TDP6
Domains : Interpro (EBI)Gln_synt_N    Gln_synth/guanido_kin_cat_dom    Gln_synth_cat_dom   
Domain families : Pfam (Sanger)Gln-synt_C (PF00120)   
Domain families : Pfam (NCBI)pfam00120   
Domain families : Smart (EMBL)Gln-synt_C (SM01230)  
Conserved Domain (NCBI)LGSN
DMDM Disease mutations51557
Blocks (Seattle)LGSN
SuperfamilyQ5TDP6
Human Protein Atlas [tissue]ENSG00000146166-LGSN [tissue]
Peptide AtlasQ5TDP6
HPRD13585
IPIIPI00009831   IPI00784892   IPI00784706   
Protein Interaction databases
DIP (DOE-UCLA)Q5TDP6
IntAct (EBI)Q5TDP6
FunCoupENSG00000146166
BioGRIDLGSN
STRING (EMBL)LGSN
ZODIACLGSN
Ontologies - Pathways
QuickGOQ5TDP6
Ontology : AmiGOglutamate-ammonia ligase activity  plasma membrane  glutamine biosynthetic process  membrane  nitrogen utilization  
Ontology : EGO-EBIglutamate-ammonia ligase activity  plasma membrane  glutamine biosynthetic process  membrane  nitrogen utilization  
NDEx NetworkLGSN
Atlas of Cancer Signalling NetworkLGSN
Wikipedia pathwaysLGSN
Orthology - Evolution
OrthoDB51557
GeneTree (enSembl)ENSG00000146166
Phylogenetic Trees/Animal Genes : TreeFamLGSN
HOVERGENQ5TDP6
HOGENOMQ5TDP6
Homologs : HomoloGeneLGSN
Homology/Alignments : Family Browser (UCSC)LGSN
Gene fusions - Rearrangements
Fusion PortalLMBRD1 6q13 LGSN 6q12 THCA
Fusion : QuiverLGSN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLGSN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LGSN
dbVarLGSN
ClinVarLGSN
1000_GenomesLGSN 
Exome Variant ServerLGSN
ExAC (Exome Aggregation Consortium)ENSG00000146166
GNOMAD BrowserENSG00000146166
Varsome BrowserLGSN
Genetic variants : HAPMAP51557
Genomic Variants (DGV)LGSN [DGVbeta]
DECIPHERLGSN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLGSN 
Mutations
ICGC Data PortalLGSN 
TCGA Data PortalLGSN 
Broad Tumor PortalLGSN
OASIS PortalLGSN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLGSN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLGSN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LGSN
DgiDB (Drug Gene Interaction Database)LGSN
DoCM (Curated mutations)LGSN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LGSN (select a term)
intoGenLGSN
Cancer3DLGSN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611470   
Orphanet
DisGeNETLGSN
MedgenLGSN
Genetic Testing Registry LGSN
NextProtQ5TDP6 [Medical]
TSGene51557
GENETestsLGSN
Target ValidationLGSN
Huge Navigator LGSN [HugePedia]
snp3D : Map Gene to Disease51557
BioCentury BCIQLGSN
ClinGenLGSN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51557
Chemical/Pharm GKB GenePA164722103
Clinical trialLGSN
Miscellaneous
canSAR (ICR)LGSN (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLGSN
EVEXLGSN
GoPubMedLGSN
iHOPLGSN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:16:20 CET 2018

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