LGSN (lengsin, lens protein with glutamine synthetase domain)

2009-09-01  

Identity

HGNC
LGSN
LOCATION
6q12
LOCUSID
51557
ALIAS
GLULD1,LGS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51557
MIM: 611470
HGNC: 21016
Ensembl: ENSG00000146166

Variants:

dbSNP: 51557
ClinVar: 51557
TCGA: ENSG00000146166
COSMIC: LGSN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146166ENST00000370657Q5TDP6
ENSG00000146166ENST00000370658Q5TDP6
ENSG00000146166ENST00000485906A0A0A0MTD2
ENSG00000146166ENST00000622415Q5TDP6

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
eye
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121074132002Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.35
216212692011Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.17
171613722006Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens.12
194598482009Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4.12
170109352006Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens.7

Citation

Dessen P

LGSN (lengsin, lens protein with glutamine synthetase domain)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51123/lgsn