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LHB (luteinizing hormone subunit beta)

Identity

Alias (NCBI)CGB4
HH23
LSH-B
LSH-beta
HGNC (Hugo) LHB
HGNC Alias symbLSH-B
CGB4
hLHB
HGNC Alias namelutropin, beta chain
 interstitial cell stimulating hormone, beta chain
HGNC Previous nameluteinizing hormone beta polypeptide
LocusID (NCBI) 3972
Atlas_Id 45872
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49015980 and ends at 49017091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)LHB   6584
Cards
Entrez_Gene (NCBI)LHB    luteinizing hormone subunit beta
AliasesCGB4; HH23; LSH-B; LSH-beta
GeneCards (Weizmann)LHB
Ensembl hg19 (Hinxton)ENSG00000104826 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104826 [Gene_View]  ENSG00000104826 [Sequence]  chr19:49015980-49017091 [Contig_View]  LHB [Vega]
ICGC DataPortalENSG00000104826
TCGA cBioPortalLHB
AceView (NCBI)LHB
Genatlas (Paris)LHB
SOURCE (Princeton)LHB
Genetics Home Reference (NIH)LHB
Genomic and cartography
GoldenPath hg38 (UCSC)LHB  -     chr19:49015980-49017091 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LHB  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathLHB - 19q13.33 [CytoView hg19]  LHB - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000104826
genome Data Viewer NCBILHB [Mapview hg19]  
OMIM152780   228300   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_000894
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LHB
Alternative Splicing GalleryENSG00000104826
Gene ExpressionLHB [ NCBI-GEO ]   LHB [ EBI - ARRAY_EXPRESS ]   LHB [ SEEK ]   LHB [ MEM ]
Gene Expression Viewer (FireBrowse)LHB [ Firebrowse - Broad ]
GenevisibleExpression of LHB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3972
GTEX Portal (Tissue expression)LHB
Human Protein AtlasENSG00000104826-LHB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01229   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01229  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01229
Splice isoforms : SwissVarP01229
PhosPhoSitePlusP01229
Domaine pattern : Prosite (Expaxy)GLYCO_HORMONE_BETA_1 (PS00261)    GLYCO_HORMONE_BETA_2 (PS00689)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Glyco_hormone_CN    Gonadotropin_bsu    Gonadotropin_bsu_CS   
Domain families : Pfam (Sanger)Cys_knot (PF00007)   
Domain families : Pfam (NCBI)pfam00007   
Domain families : Smart (EMBL)GHB (SM00068)  
Conserved Domain (NCBI)LHB
Blocks (Seattle)LHB
PDB (RSDB)1M92   
PDB Europe1M92   
PDB (PDBSum)1M92   
PDB (IMB)1M92   
Structural Biology KnowledgeBase1M92   
SCOP (Structural Classification of Proteins)1M92   
CATH (Classification of proteins structures)1M92   
SuperfamilyP01229
Human Protein Atlas [tissue]ENSG00000104826-LHB [tissue]
Peptide AtlasP01229
HPRD01072
IPIIPI00000854   IPI00937264   
Protein Interaction databases
DIP (DOE-UCLA)P01229
IntAct (EBI)P01229
BioGRIDLHB
STRING (EMBL)LHB
ZODIACLHB
Ontologies - Pathways
QuickGOP01229
Ontology : AmiGOsignaling receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  Golgi lumen  progesterone biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  cell-cell signaling  male gonad development  hormone-mediated signaling pathway  peptide hormone processing  
Ontology : EGO-EBIsignaling receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  Golgi lumen  progesterone biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  cell-cell signaling  male gonad development  hormone-mediated signaling pathway  peptide hormone processing  
Pathways : KEGGNeuroactive ligand-receptor interaction    GnRH signaling pathway    Ovarian steroidogenesis    Prolactin signaling pathway   
NDEx NetworkLHB
Atlas of Cancer Signalling NetworkLHB
Wikipedia pathwaysLHB
Orthology - Evolution
OrthoDB3972
GeneTree (enSembl)ENSG00000104826
Phylogenetic Trees/Animal Genes : TreeFamLHB
HOGENOMP01229
Homologs : HomoloGeneLHB
Homology/Alignments : Family Browser (UCSC)LHB
Gene fusions - Rearrangements
Fusion : QuiverLHB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHB [hg38]
dbVarLHB
ClinVarLHB
MonarchLHB
1000_GenomesLHB 
Exome Variant ServerLHB
GNOMAD BrowserENSG00000104826
Varsome BrowserLHB
Genomic Variants (DGV)LHB [DGVbeta]
DECIPHERLHB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLHB 
Mutations
ICGC Data PortalLHB 
TCGA Data PortalLHB 
Broad Tumor PortalLHB
OASIS PortalLHB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLHB
Mutations and Diseases : HGMDLHB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LHB
DgiDB (Drug Gene Interaction Database)LHB
DoCM (Curated mutations)LHB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHB (select a term)
intoGenLHB
Cancer3DLHB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM152780    228300   
Orphanet21841   
DisGeNETLHB
MedgenLHB
Genetic Testing Registry LHB
NextProtP01229 [Medical]
GENETestsLHB
Target ValidationLHB
Huge Navigator LHB [HugePedia]
ClinGenLHB
Clinical trials, drugs, therapy
MyCancerGenomeLHB
Protein Interactions : CTD
Pharm GKB GenePA30356
PharosP01229
Clinical trialLHB
Miscellaneous
canSAR (ICR)LHB (select the gene name)
HarmonizomeLHB
DataMed IndexLHB
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLHB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:28:54 CET 2021

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