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LHFPL2 (LHFPL tetraspan subfamily member 2)

Identity

Alias_symbol (synonym)KIAA0206
Other alias-
HGNC (Hugo) LHFPL2
LocusID (NCBI) 10184
Atlas_Id 56266
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 78485215 and ends at 78648825 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HIST1H2AC (6p22.2) / LHFPL2 (5q14.1)KCNMA1 (10q22.3) / LHFPL2 (5q14.1)LHFPL2 (5q14.1) / ANXA2 (15q22.2)
LHFPL2 (5q14.1) / CRK (17p13.3)LHFPL2 (5q14.1) / HIST1H2AC (6p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;6)(q14;p22) HIST1H2AC/LHFPL2
t(5;6)(q14;p22) LHFPL2/HIST1H2AC

External links

Nomenclature
HGNC (Hugo)LHFPL2   6588
Cards
Entrez_Gene (NCBI)LHFPL2  10184  LHFPL tetraspan subfamily member 2
Aliases
GeneCards (Weizmann)LHFPL2
Ensembl hg19 (Hinxton)ENSG00000145685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145685 [Gene_View]  chr5:78485215-78648825 [Contig_View]  LHFPL2 [Vega]
ICGC DataPortalENSG00000145685
TCGA cBioPortalLHFPL2
AceView (NCBI)LHFPL2
Genatlas (Paris)LHFPL2
WikiGenes10184
SOURCE (Princeton)LHFPL2
Genetics Home Reference (NIH)LHFPL2
Genomic and cartography
GoldenPath hg38 (UCSC)LHFPL2  -     chr5:78485215-78648825 -  5q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LHFPL2  -     5q14.1   [Description]    (hg19-Feb_2009)
EnsemblLHFPL2 - 5q14.1 [CytoView hg19]  LHFPL2 - 5q14.1 [CytoView hg38]
Mapping of homologs : NCBILHFPL2 [Mapview hg19]  LHFPL2 [Mapview hg38]
OMIM609718   
Gene and transcription
Genbank (Entrez)AK091868 AK125227 AY309920 BC136335 BC136336
RefSeq transcript (Entrez)NM_005779
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LHFPL2
Cluster EST : UnigeneHs.670094 [ NCBI ]
CGAP (NCI)Hs.670094
Alternative Splicing GalleryENSG00000145685
Gene ExpressionLHFPL2 [ NCBI-GEO ]   LHFPL2 [ EBI - ARRAY_EXPRESS ]   LHFPL2 [ SEEK ]   LHFPL2 [ MEM ]
Gene Expression Viewer (FireBrowse)LHFPL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10184
GTEX Portal (Tissue expression)LHFPL2
Human Protein AtlasENSG00000145685-LHFPL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZUX7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZUX7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZUX7
Splice isoforms : SwissVarQ6ZUX7
PhosPhoSitePlusQ6ZUX7
Domains : Interpro (EBI)Lipome_HGMIC_fus_partner-like   
Domain families : Pfam (Sanger)L_HMGIC_fpl (PF10242)   
Domain families : Pfam (NCBI)pfam10242   
Conserved Domain (NCBI)LHFPL2
DMDM Disease mutations10184
Blocks (Seattle)LHFPL2
SuperfamilyQ6ZUX7
Human Protein Atlas [tissue]ENSG00000145685-LHFPL2 [tissue]
Peptide AtlasQ6ZUX7
HPRD17272
IPIIPI00445977   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZUX7
IntAct (EBI)Q6ZUX7
FunCoupENSG00000145685
BioGRIDLHFPL2
STRING (EMBL)LHFPL2
ZODIACLHFPL2
Ontologies - Pathways
QuickGOQ6ZUX7
Ontology : AmiGOplatelet degranulation  molecular_function  cellular_component  plasma membrane  single fertilization  biological_process  integral component of membrane  platelet alpha granule membrane  development of primary female sexual characteristics  development of primary male sexual characteristics  positive regulation of fertilization  
Ontology : EGO-EBIplatelet degranulation  molecular_function  cellular_component  plasma membrane  single fertilization  biological_process  integral component of membrane  platelet alpha granule membrane  development of primary female sexual characteristics  development of primary male sexual characteristics  positive regulation of fertilization  
NDEx NetworkLHFPL2
Atlas of Cancer Signalling NetworkLHFPL2
Wikipedia pathwaysLHFPL2
Orthology - Evolution
OrthoDB10184
GeneTree (enSembl)ENSG00000145685
Phylogenetic Trees/Animal Genes : TreeFamLHFPL2
HOVERGENQ6ZUX7
HOGENOMQ6ZUX7
Homologs : HomoloGeneLHFPL2
Homology/Alignments : Family Browser (UCSC)LHFPL2
Gene fusions - Rearrangements
Fusion : QuiverLHFPL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHFPL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LHFPL2
dbVarLHFPL2
ClinVarLHFPL2
1000_GenomesLHFPL2 
Exome Variant ServerLHFPL2
ExAC (Exome Aggregation Consortium)ENSG00000145685
GNOMAD BrowserENSG00000145685
Genetic variants : HAPMAP10184
Genomic Variants (DGV)LHFPL2 [DGVbeta]
DECIPHERLHFPL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLHFPL2 
Mutations
ICGC Data PortalLHFPL2 
TCGA Data PortalLHFPL2 
Broad Tumor PortalLHFPL2
OASIS PortalLHFPL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHFPL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLHFPL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LHFPL2
DgiDB (Drug Gene Interaction Database)LHFPL2
DoCM (Curated mutations)LHFPL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHFPL2 (select a term)
intoGenLHFPL2
Cancer3DLHFPL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609718   
Orphanet
DisGeNETLHFPL2
MedgenLHFPL2
Genetic Testing Registry LHFPL2
NextProtQ6ZUX7 [Medical]
TSGene10184
GENETestsLHFPL2
Target ValidationLHFPL2
Huge Navigator LHFPL2 [HugePedia]
snp3D : Map Gene to Disease10184
BioCentury BCIQLHFPL2
ClinGenLHFPL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10184
Chemical/Pharm GKB GenePA30360
Clinical trialLHFPL2
Miscellaneous
canSAR (ICR)LHFPL2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLHFPL2
EVEXLHFPL2
GoPubMedLHFPL2
iHOPLHFPL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:20:23 CET 2018
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