LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase)

2017-10-01  

Identity

HGNC
LHPP
LOCATION
10q26.13
LOCUSID
64077
ALIAS
HDHD2B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64077
MIM: 617231
HGNC: 30042
Ensembl: ENSG00000107902

Variants:

dbSNP: 64077
ClinVar: 64077
TCGA: ENSG00000107902
COSMIC: LHPP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107902ENST00000368839Q9H008
ENSG00000107902ENST00000368842Q9H008
ENSG00000107902ENST00000392757Q5T1Z0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Oxidative phosphorylationKEGGhsa00190
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine ribonucleoside monophosphate biosynthesisREACTOMER-HSA-73817

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
277498452016Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.36
182684992009Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.25
182684992009Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.25
295622342018The protein histidine phosphatase LHPP is a tumour suppressor.20
275316262017The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.11
278436512016Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder.7
299448862018Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT.5

Citation

Dessen P

LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57116/lhpp