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LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase)

Identity

Other aliasHDHD2B
HGNC (Hugo) LHPP
LocusID (NCBI) 64077
Atlas_Id 57116
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 124461843 and ends at 124614140 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LHPP (10q26.13) / FANK1 (10q26.2)LHPP (10q26.13) / FLNA (Xq28)LHPP (10q26.13) / TANGO6 (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LHPP   30042
Cards
Entrez_Gene (NCBI)LHPP  64077  phospholysine phosphohistidine inorganic pyrophosphate phosphatase
AliasesHDHD2B
GeneCards (Weizmann)LHPP
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr10:124461843-124614140 [Contig_View]  LHPP [Vega]
TCGA cBioPortalLHPP
AceView (NCBI)LHPP
Genatlas (Paris)LHPP
WikiGenes64077
SOURCE (Princeton)LHPP
Genetics Home Reference (NIH)LHPP
Genomic and cartography
GoldenPath hg38 (UCSC)LHPP  -     chr10:124461843-124614140 +  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LHPP  -     10q26.13   [Description]    (hg19-Feb_2009)
EnsemblLHPP - 10q26.13 [CytoView hg19]  LHPP - 10q26.13 [CytoView hg38]
Mapping of homologs : NCBILHPP [Mapview hg19]  LHPP [Mapview hg38]
OMIM617231   
Gene and transcription
Genbank (Entrez)AK055532 AW631352 BC007324 BC073172 BC110344
RefSeq transcript (Entrez)NM_001167880 NM_001318331 NM_001318332 NM_022126
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LHPP
Cluster EST : UnigeneHs.527748 [ NCBI ]
CGAP (NCI)Hs.527748
Gene ExpressionLHPP [ NCBI-GEO ]   LHPP [ EBI - ARRAY_EXPRESS ]   LHPP [ SEEK ]   LHPP [ MEM ]
Gene Expression Viewer (FireBrowse)LHPP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64077
GTEX Portal (Tissue expression)LHPP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H008   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H008  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H008
Splice isoforms : SwissVarQ9H008
Catalytic activity : Enzyme3.1.3.- [ Enzyme-Expasy ]   3.1.3.-3.1.3.- [ IntEnz-EBI ]   3.1.3.- [ BRENDA ]   3.1.3.- [ KEGG ]   
PhosPhoSitePlusQ9H008
Domains : Interpro (EBI)HAD-like_dom    HAD-SF_hydro_IIA    HAD-SF_hydro_IIA_hyp2    NPhePase-like_dom   
Domain families : Pfam (Sanger)Hydrolase_6 (PF13344)   
Domain families : Pfam (NCBI)pfam13344   
Conserved Domain (NCBI)LHPP
DMDM Disease mutations64077
Blocks (Seattle)LHPP
PDB (SRS)2X4D   
PDB (PDBSum)2X4D   
PDB (IMB)2X4D   
PDB (RSDB)2X4D   
Structural Biology KnowledgeBase2X4D   
SCOP (Structural Classification of Proteins)2X4D   
CATH (Classification of proteins structures)2X4D   
SuperfamilyQ9H008
Peptide AtlasQ9H008
IPIIPI00005474   IPI00642397   IPI00921556   IPI00643622   
Protein Interaction databases
DIP (DOE-UCLA)Q9H008
IntAct (EBI)Q9H008
BioGRIDLHPP
STRING (EMBL)LHPP
ZODIACLHPP
Ontologies - Pathways
QuickGOQ9H008
Ontology : AmiGOmagnesium ion binding  inorganic diphosphatase activity  inorganic diphosphatase activity  nucleus  cytosol  cytosol  protein dephosphorylation  phosphate-containing compound metabolic process  purine ribonucleoside monophosphate biosynthetic process  dephosphorylation  nuclear speck  phosphatase activity  protein homodimerization activity  protein histidine phosphatase activity  
Ontology : EGO-EBImagnesium ion binding  inorganic diphosphatase activity  inorganic diphosphatase activity  nucleus  cytosol  cytosol  protein dephosphorylation  phosphate-containing compound metabolic process  purine ribonucleoside monophosphate biosynthetic process  dephosphorylation  nuclear speck  phosphatase activity  protein homodimerization activity  protein histidine phosphatase activity  
Pathways : KEGGOxidative phosphorylation   
NDEx NetworkLHPP
Atlas of Cancer Signalling NetworkLHPP
Wikipedia pathwaysLHPP
Orthology - Evolution
OrthoDB64077
Phylogenetic Trees/Animal Genes : TreeFamLHPP
HOVERGENQ9H008
HOGENOMQ9H008
Homologs : HomoloGeneLHPP
Homology/Alignments : Family Browser (UCSC)LHPP
Gene fusions - Rearrangements
Tumor Fusion PortalLHPP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHPP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LHPP
dbVarLHPP
ClinVarLHPP
1000_GenomesLHPP 
Exome Variant ServerLHPP
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP64077
Genomic Variants (DGV)LHPP [DGVbeta]
DECIPHERLHPP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLHPP 
Mutations
ICGC Data PortalLHPP 
TCGA Data PortalLHPP 
Broad Tumor PortalLHPP
OASIS PortalLHPP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHPP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLHPP
BioMutasearch LHPP
DgiDB (Drug Gene Interaction Database)LHPP
DoCM (Curated mutations)LHPP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHPP (select a term)
intoGenLHPP
Cancer3DLHPP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617231   
Orphanet
DisGeNETLHPP
MedgenLHPP
Genetic Testing Registry LHPP
NextProtQ9H008 [Medical]
TSGene64077
GENETestsLHPP
Target ValidationLHPP
Huge Navigator LHPP [HugePedia]
snp3D : Map Gene to Disease64077
BioCentury BCIQLHPP
ClinGenLHPP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64077
Chemical/Pharm GKB GenePA165548763
Clinical trialLHPP
Miscellaneous
canSAR (ICR)LHPP (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLHPP
EVEXLHPP
GoPubMedLHPP
iHOPLHPP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:19:50 CET 2017

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