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LHX2 (LIM homeobox 2)

Identity

Alias_symbol (synonym)LH-2
hLhx2
Other aliasLH2
HGNC (Hugo) LHX2
LocusID (NCBI) 9355
Atlas_Id 54067
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 126773889 and ends at 126795442 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAMTS13 (9q34.2) / LHX2 (9q33.3)IGH (14q32.33) / LHX2 (9q33.3)LHX2 (9q33.3) / NR2F1 (5q15)
ADAMTS13 9q34.2 / LHX2 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;14)(q33;q32) IGH/LHX2


External links

Nomenclature
HGNC (Hugo)LHX2   6594
Cards
Entrez_Gene (NCBI)LHX2  9355  LIM homeobox 2
AliasesLH2; hLhx2
GeneCards (Weizmann)LHX2
Ensembl hg19 (Hinxton)ENSG00000106689 [Gene_View]  chr9:126773889-126795442 [Contig_View]  LHX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106689 [Gene_View]  chr9:126773889-126795442 [Contig_View]  LHX2 [Vega]
ICGC DataPortalENSG00000106689
TCGA cBioPortalLHX2
AceView (NCBI)LHX2
Genatlas (Paris)LHX2
WikiGenes9355
SOURCE (Princeton)LHX2
Genetics Home Reference (NIH)LHX2
Genomic and cartography
GoldenPath hg19 (UCSC)LHX2  -     chr9:126773889-126795442 +  9q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LHX2  -     9q33.3   [Description]    (hg38-Dec_2013)
EnsemblLHX2 - 9q33.3 [CytoView hg19]  LHX2 - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBILHX2 [Mapview hg19]  LHX2 [Mapview hg38]
OMIM603759   
Gene and transcription
Genbank (Entrez)AK027597 AK094511 BC034458 BC093662 BC112185
RefSeq transcript (Entrez)NM_004789
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)LHX2
Cluster EST : UnigeneHs.696425 [ NCBI ]
CGAP (NCI)Hs.696425
Alternative Splicing GalleryENSG00000106689
Gene ExpressionLHX2 [ NCBI-GEO ]   LHX2 [ EBI - ARRAY_EXPRESS ]   LHX2 [ SEEK ]   LHX2 [ MEM ]
Gene Expression Viewer (FireBrowse)LHX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9355
GTEX Portal (Tissue expression)LHX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50458   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50458  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50458
Splice isoforms : SwissVarP50458
PhosPhoSitePlusP50458
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    Znf_LIM   
Domain families : Pfam (Sanger)Homeobox (PF00046)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00046    pfam00412   
Domain families : Smart (EMBL)HOX (SM00389)  LIM (SM00132)  
Conserved Domain (NCBI)LHX2
DMDM Disease mutations9355
Blocks (Seattle)LHX2
SuperfamilyP50458
Human Protein AtlasENSG00000106689
Peptide AtlasP50458
HPRD04786
IPIIPI00032144   IPI00647069   
Protein Interaction databases
DIP (DOE-UCLA)P50458
IntAct (EBI)P50458
FunCoupENSG00000106689
BioGRIDLHX2
STRING (EMBL)LHX2
ZODIACLHX2
Ontologies - Pathways
QuickGOP50458
Ontology : AmiGOtranscription factor activity, RNA polymerase II transcription factor binding  neural tube closure  hair follicle development  chromatin binding  nucleus  transcription, DNA-templated  axon guidance  mesoderm development  zinc ion binding  dorsal/ventral pattern formation  olfactory bulb development  telencephalon regionalization  cerebral cortex development  sequence-specific DNA binding  maintenance of epithelial cell apical/basal polarity  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  axon extension  retina development in camera-type eye  negative regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II transcription factor binding  neural tube closure  hair follicle development  chromatin binding  nucleus  transcription, DNA-templated  axon guidance  mesoderm development  zinc ion binding  dorsal/ventral pattern formation  olfactory bulb development  telencephalon regionalization  cerebral cortex development  sequence-specific DNA binding  maintenance of epithelial cell apical/basal polarity  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  axon extension  retina development in camera-type eye  negative regulation of transcription regulatory region DNA binding  
NDEx NetworkLHX2
Atlas of Cancer Signalling NetworkLHX2
Wikipedia pathwaysLHX2
Orthology - Evolution
OrthoDB9355
GeneTree (enSembl)ENSG00000106689
Phylogenetic Trees/Animal Genes : TreeFamLHX2
HOVERGENP50458
HOGENOMP50458
Homologs : HomoloGeneLHX2
Homology/Alignments : Family Browser (UCSC)LHX2
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS13/LHX2 [9q34.2/9q33.3]  [t(9;9)(q33;q34)]  
Fusion : MitelmanIGH/LHX2 [14q32.33/9q33.3]  [t(9;14)(q33;q32)]  
Fusion: TCGAADAMTS13 9q34.2 LHX2 9q33.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LHX2
dbVarLHX2
ClinVarLHX2
1000_GenomesLHX2 
Exome Variant ServerLHX2
ExAC (Exome Aggregation Consortium)LHX2 (select the gene name)
Genetic variants : HAPMAP9355
Genomic Variants (DGV)LHX2 [DGVbeta]
DECIPHER (Syndromes)9:126773889-126795442  ENSG00000106689
CONAN: Copy Number AnalysisLHX2 
Mutations
ICGC Data PortalLHX2 
TCGA Data PortalLHX2 
Broad Tumor PortalLHX2
OASIS PortalLHX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLHX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LHX2
DgiDB (Drug Gene Interaction Database)LHX2
DoCM (Curated mutations)LHX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHX2 (select a term)
intoGenLHX2
Cancer3DLHX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603759   
Orphanet
MedgenLHX2
Genetic Testing Registry LHX2
NextProtP50458 [Medical]
TSGene9355
GENETestsLHX2
Huge Navigator LHX2 [HugePedia]
snp3D : Map Gene to Disease9355
BioCentury BCIQLHX2
ClinGenLHX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9355
Chemical/Pharm GKB GenePA30365
Clinical trialLHX2
Miscellaneous
canSAR (ICR)LHX2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLHX2
EVEXLHX2
GoPubMedLHX2
iHOPLHX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:12:47 CET 2017

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