LHX2 (LIM homeobox 2)

2014-07-01  

Identity

HGNC
LHX2
LOCATION
9q33.3
LOCUSID
9355
ALIAS
LH2,hLhx2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9355
MIM: 603759
HGNC: 6594
Ensembl: ENSG00000106689

Variants:

dbSNP: 9355
ClinVar: 9355
TCGA: ENSG00000106689
COSMIC: LHX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106689ENST00000373615P50458
ENSG00000106689ENST00000446480H7C0H1
ENSG00000106689ENST00000488674U3KQT5
ENSG00000106689ENST00000560961H0YM35

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
255053332014The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.22
238047532013LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1.19
233076372014Lhx2 regulates the development of the forebrain hem system.18
244234922014LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.15
261892142015miR-1238 inhibits cell proliferation by targeting LHX2 in non-small cell lung cancer.12
307919322019MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by down-regulating LHX2.10
253241712014Oncogenicity of LHX2 in pancreatic ductal adenocarcinoma.8
225356462012Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities.4
209495372010Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large schizencephaly cohort.2
212034062010Mutations in the LHX2 gene are not a frequent cause of micro/anophthalmia.2

Citation

Dessen P

LHX2 (LIM homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54067/lhx2