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LHX3 (LIM homeobox 3)

Identity

Other aliasCPHD3
LIM3
M2-LHX3
HGNC (Hugo) LHX3
LocusID (NCBI) 8022
Atlas_Id 41151
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 136196250 and ends at 136205129 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LHX3 (9q34.3) / DDB2 (11p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LHX3   6595
Cards
Entrez_Gene (NCBI)LHX3  8022  LIM homeobox 3
AliasesCPHD3; LIM3; M2-LHX3
GeneCards (Weizmann)LHX3
Ensembl hg19 (Hinxton)ENSG00000107187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107187 [Gene_View]  ENSG00000107187 [Sequence]  chr9:136196250-136205129 [Contig_View]  LHX3 [Vega]
ICGC DataPortalENSG00000107187
TCGA cBioPortalLHX3
AceView (NCBI)LHX3
Genatlas (Paris)LHX3
WikiGenes8022
SOURCE (Princeton)LHX3
Genetics Home Reference (NIH)LHX3
Genomic and cartography
GoldenPath hg38 (UCSC)LHX3  -     chr9:136196250-136205129 -  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LHX3  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblLHX3 - 9q34.3 [CytoView hg19]  LHX3 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBILHX3 [Mapview hg19]  LHX3 [Mapview hg38]
OMIM221750   600577   
Gene and transcription
Genbank (Entrez)AB593062 AB593063 AB593064 AB593065 AB593066
RefSeq transcript (Entrez)NM_001363746 NM_014564 NM_178138
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LHX3
Cluster EST : UnigeneHs.148427 [ NCBI ]
CGAP (NCI)Hs.148427
Alternative Splicing GalleryENSG00000107187
Gene ExpressionLHX3 [ NCBI-GEO ]   LHX3 [ EBI - ARRAY_EXPRESS ]   LHX3 [ SEEK ]   LHX3 [ MEM ]
Gene Expression Viewer (FireBrowse)LHX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8022
GTEX Portal (Tissue expression)LHX3
Human Protein AtlasENSG00000107187-LHX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBR4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBR4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBR4
Splice isoforms : SwissVarQ9UBR4
PhosPhoSitePlusQ9UBR4
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Znf_LIM   
Domain families : Pfam (Sanger)Homeobox (PF00046)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00046    pfam00412   
Domain families : Smart (EMBL)HOX (SM00389)  LIM (SM00132)  
Conserved Domain (NCBI)LHX3
DMDM Disease mutations8022
Blocks (Seattle)LHX3
SuperfamilyQ9UBR4
Human Protein Atlas [tissue]ENSG00000107187-LHX3 [tissue]
Peptide AtlasQ9UBR4
HPRD02783
IPIIPI00002747   IPI00220680   IPI00182961   IPI00387129   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBR4
IntAct (EBI)Q9UBR4
FunCoupENSG00000107187
BioGRIDLHX3
STRING (EMBL)LHX3
ZODIACLHX3
Ontologies - Pathways
QuickGOQ9UBR4
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II transcription factor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  placenta development  nucleus  transcription factor complex  motor neuron axon guidance  animal organ morphogenesis  spinal cord motor neuron cell fate specification  ventral spinal cord interneuron specification  medial motor column neuron differentiation  spinal cord association neuron differentiation  pituitary gland development  lung development  negative regulation of apoptotic process  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  metal ion binding  inner ear development  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II transcription factor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  placenta development  nucleus  transcription factor complex  motor neuron axon guidance  animal organ morphogenesis  spinal cord motor neuron cell fate specification  ventral spinal cord interneuron specification  medial motor column neuron differentiation  spinal cord association neuron differentiation  pituitary gland development  lung development  negative regulation of apoptotic process  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  metal ion binding  inner ear development  
NDEx NetworkLHX3
Atlas of Cancer Signalling NetworkLHX3
Wikipedia pathwaysLHX3
Orthology - Evolution
OrthoDB8022
GeneTree (enSembl)ENSG00000107187
Phylogenetic Trees/Animal Genes : TreeFamLHX3
HOGENOMQ9UBR4
Homologs : HomoloGeneLHX3
Homology/Alignments : Family Browser (UCSC)LHX3
Gene fusions - Rearrangements
Fusion : QuiverLHX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LHX3
dbVarLHX3
ClinVarLHX3
1000_GenomesLHX3 
Exome Variant ServerLHX3
ExAC (Exome Aggregation Consortium)ENSG00000107187
GNOMAD BrowserENSG00000107187
Varsome BrowserLHX3
Genetic variants : HAPMAP8022
Genomic Variants (DGV)LHX3 [DGVbeta]
DECIPHERLHX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLHX3 
Mutations
ICGC Data PortalLHX3 
TCGA Data PortalLHX3 
Broad Tumor PortalLHX3
OASIS PortalLHX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLHX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LHX3
DgiDB (Drug Gene Interaction Database)LHX3
DoCM (Curated mutations)LHX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHX3 (select a term)
intoGenLHX3
Cancer3DLHX3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM221750    600577   
Orphanet19033    19213   
DisGeNETLHX3
MedgenLHX3
Genetic Testing Registry LHX3
NextProtQ9UBR4 [Medical]
TSGene8022
GENETestsLHX3
Target ValidationLHX3
Huge Navigator LHX3 [HugePedia]
snp3D : Map Gene to Disease8022
BioCentury BCIQLHX3
ClinGenLHX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8022
Chemical/Pharm GKB GenePA30366
Clinical trialLHX3
Miscellaneous
canSAR (ICR)LHX3 (select the gene name)
DataMed IndexLHX3
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLHX3
EVEXLHX3
GoPubMedLHX3
iHOPLHX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:20:18 CET 2019

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