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LHX3 (LIM homeobox 3)

Identity

Other aliasCPHD3
LIM3
M2-LHX3
HGNC (Hugo) LHX3
LocusID (NCBI) 8022
Atlas_Id 41151
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 139088096 and ends at 139095019 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LHX3 (9q34.3) / DDB2 (11p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LHX3   6595
Cards
Entrez_Gene (NCBI)LHX3  8022  LIM homeobox 3
AliasesCPHD3; LIM3; M2-LHX3
GeneCards (Weizmann)LHX3
Ensembl hg19 (Hinxton)ENSG00000107187 [Gene_View]  chr9:139088096-139095019 [Contig_View]  LHX3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000107187 [Gene_View]  chr9:139088096-139095019 [Contig_View]  LHX3 [Vega]
ICGC DataPortalENSG00000107187
TCGA cBioPortalLHX3
AceView (NCBI)LHX3
Genatlas (Paris)LHX3
WikiGenes8022
SOURCE (Princeton)LHX3
Genetics Home Reference (NIH)LHX3
Genomic and cartography
GoldenPath hg19 (UCSC)LHX3  -     chr9:139088096-139095019 -  9q34.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LHX3  -     9q34.3   [Description]    (hg38-Dec_2013)
EnsemblLHX3 - 9q34.3 [CytoView hg19]  LHX3 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBILHX3 [Mapview hg19]  LHX3 [Mapview hg38]
OMIM221750   600577   
Gene and transcription
Genbank (Entrez)AB593062 AB593063 AB593064 AB593065 AB593066
RefSeq transcript (Entrez)NM_014564 NM_178138
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_008097 NT_008470 NW_004929368
Consensus coding sequences : CCDS (NCBI)LHX3
Cluster EST : UnigeneHs.148427 [ NCBI ]
CGAP (NCI)Hs.148427
Alternative Splicing GalleryENSG00000107187
Gene ExpressionLHX3 [ NCBI-GEO ]   LHX3 [ EBI - ARRAY_EXPRESS ]   LHX3 [ SEEK ]   LHX3 [ MEM ]
Gene Expression Viewer (FireBrowse)LHX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8022
GTEX Portal (Tissue expression)LHX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBR4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBR4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBR4
Splice isoforms : SwissVarQ9UBR4
PhosPhoSitePlusQ9UBR4
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    Znf_LIM   
Domain families : Pfam (Sanger)Homeobox (PF00046)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00046    pfam00412   
Domain families : Smart (EMBL)HOX (SM00389)  LIM (SM00132)  
Conserved Domain (NCBI)LHX3
DMDM Disease mutations8022
Blocks (Seattle)LHX3
SuperfamilyQ9UBR4
Human Protein AtlasENSG00000107187
Peptide AtlasQ9UBR4
HPRD02783
IPIIPI00002747   IPI00220680   IPI00182961   IPI00387129   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBR4
IntAct (EBI)Q9UBR4
FunCoupENSG00000107187
BioGRIDLHX3
STRING (EMBL)LHX3
ZODIACLHX3
Ontologies - Pathways
QuickGOQ9UBR4
Ontology : AmiGOtranscription factor activity, RNA polymerase II transcription factor binding  RNA polymerase II transcription factor binding  placenta development  nucleus  transcription factor complex  transcription, DNA-templated  motor neuron axon guidance  zinc ion binding  organ morphogenesis  spinal cord motor neuron cell fate specification  ventral spinal cord interneuron specification  medial motor column neuron differentiation  spinal cord association neuron differentiation  pituitary gland development  lung development  negative regulation of apoptotic process  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  inner ear development  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II transcription factor binding  RNA polymerase II transcription factor binding  placenta development  nucleus  transcription factor complex  transcription, DNA-templated  motor neuron axon guidance  zinc ion binding  organ morphogenesis  spinal cord motor neuron cell fate specification  ventral spinal cord interneuron specification  medial motor column neuron differentiation  spinal cord association neuron differentiation  pituitary gland development  lung development  negative regulation of apoptotic process  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  inner ear development  
NDEx NetworkLHX3
Atlas of Cancer Signalling NetworkLHX3
Wikipedia pathwaysLHX3
Orthology - Evolution
OrthoDB8022
GeneTree (enSembl)ENSG00000107187
Phylogenetic Trees/Animal Genes : TreeFamLHX3
HOVERGENQ9UBR4
HOGENOMQ9UBR4
Homologs : HomoloGeneLHX3
Homology/Alignments : Family Browser (UCSC)LHX3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LHX3
dbVarLHX3
ClinVarLHX3
1000_GenomesLHX3 
Exome Variant ServerLHX3
ExAC (Exome Aggregation Consortium)LHX3 (select the gene name)
Genetic variants : HAPMAP8022
Genomic Variants (DGV)LHX3 [DGVbeta]
DECIPHER (Syndromes)9:139088096-139095019  ENSG00000107187
CONAN: Copy Number AnalysisLHX3 
Mutations
ICGC Data PortalLHX3 
TCGA Data PortalLHX3 
Broad Tumor PortalLHX3
OASIS PortalLHX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLHX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LHX3
DgiDB (Drug Gene Interaction Database)LHX3
DoCM (Curated mutations)LHX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHX3 (select a term)
intoGenLHX3
Cancer3DLHX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM221750    600577   
Orphanet19033    19213   
MedgenLHX3
Genetic Testing Registry LHX3
NextProtQ9UBR4 [Medical]
TSGene8022
GENETestsLHX3
Huge Navigator LHX3 [HugePedia]
snp3D : Map Gene to Disease8022
BioCentury BCIQLHX3
ClinGenLHX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8022
Chemical/Pharm GKB GenePA30366
Clinical trialLHX3
Miscellaneous
canSAR (ICR)LHX3 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLHX3
EVEXLHX3
GoPubMedLHX3
iHOPLHX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:12:47 CET 2017

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