| Nomenclature |
|---|
| HGNC (Hugo) | LHX4 21734 |
| Cards |
|---|
| Entrez_Gene (NCBI) | LHX4 LIM homeobox 4 |
| Aliases | CPHD4 |
| GeneCards (Weizmann) | LHX4 |
| Ensembl hg19 (Hinxton) | ENSG00000121454 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000121454 [Gene_View] ENSG00000121454 [Sequence] chr1:180230264-180278984 [Contig_View] LHX4 [Vega] |
| ICGC DataPortal | ENSG00000121454 |
| TCGA cBioPortal | LHX4 |
| AceView (NCBI) | LHX4 |
| Genatlas (Paris) | LHX4 |
| SOURCE (Princeton) | LHX4 |
| Genetics Home Reference (NIH) | LHX4 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | LHX4 - chr1:180230264-180278984 + 1q25.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | LHX4 - 1q25.2 [Description] (hg19-Feb_2009) |
| GoldenPath | LHX4 - 1q25.2 [CytoView hg19] LHX4 - 1q25.2 [CytoView hg38] |
| ImmunoBase | ENSG00000121454 |
| genome Data Viewer NCBI | LHX4 [Mapview hg19] |
| OMIM | 262700 602146 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB037683 AB055703 AB055704 AF179849 AF282899 |
| RefSeq transcript (Entrez) | NM_033343 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | LHX4 |
| Alternative Splicing Gallery | ENSG00000121454 |
| Gene Expression | LHX4 [ NCBI-GEO ] LHX4 [ EBI - ARRAY_EXPRESS ]
LHX4 [ SEEK ] LHX4 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | LHX4 [ Firebrowse - Broad ] |
| Genevisible | Expression of LHX4 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 89884 |
| GTEX Portal (Tissue expression) | LHX4 |
| Human Protein Atlas | ENSG00000121454-LHX4 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q969G2 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q969G2 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q969G2 |
| Splice isoforms : SwissVar | Q969G2 |
| PhosPhoSitePlus | Q969G2 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) LIM_DOMAIN_1 (PS00478) LIM_DOMAIN_2 (PS50023) |
| Domains : Interpro (EBI) | Homeobox-like_sf Homeobox_CS Homeobox_dom Znf_LIM |
| Domain families : Pfam (Sanger) | Homeodomain (PF00046) LIM (PF00412) |
| Domain families : Pfam (NCBI) | pfam00046 pfam00412 |
| Domain families : Smart (EMBL) | HOX (SM00389) LIM (SM00132) |
| Conserved Domain (NCBI) | LHX4 |
| Blocks (Seattle) | LHX4 |
| PDB (RSDB) | 5HOD |
| PDB Europe | 5HOD |
| PDB (PDBSum) | 5HOD |
| PDB (IMB) | 5HOD |
| Structural Biology KnowledgeBase | 5HOD |
| SCOP (Structural Classification of Proteins) | 5HOD |
| CATH (Classification of proteins structures) | 5HOD |
| Superfamily | Q969G2 |
| Human Protein Atlas [tissue] | ENSG00000121454-LHX4 [tissue] |
| Peptide Atlas | Q969G2 |
| HPRD | 03686 |
| IPI | IPI00169275 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q969G2 |
| IntAct (EBI) | Q969G2 |
| BioGRID | LHX4 |
| STRING (EMBL) | LHX4 |
| ZODIAC | LHX4 |
| Ontologies - Pathways |
|---|
| QuickGO | Q969G2 |
| Ontology : AmiGO | chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific placenta development protein binding nucleus regulation of transcription by RNA polymerase II motor neuron axon guidance methyl-CpG binding animal organ morphogenesis medial motor column neuron differentiation neuron differentiation negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription by RNA polymerase II metal ion binding sequence-specific double-stranded DNA binding |
| Ontology : EGO-EBI | chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific placenta development protein binding nucleus regulation of transcription by RNA polymerase II motor neuron axon guidance methyl-CpG binding animal organ morphogenesis medial motor column neuron differentiation neuron differentiation negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription by RNA polymerase II metal ion binding sequence-specific double-stranded DNA binding |
| NDEx Network | LHX4 |
| Atlas of Cancer Signalling Network | LHX4 |
| Wikipedia pathways | LHX4 |
| Orthology - Evolution |
|---|
| OrthoDB | 89884 |
| GeneTree (enSembl) | ENSG00000121454 |
| Phylogenetic Trees/Animal Genes : TreeFam | LHX4 |
| HOGENOM | Q969G2 |
| Homologs : HomoloGene | LHX4 |
| Homology/Alignments : Family Browser (UCSC) | LHX4 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CCT8/LHX4 [21q21.3/1q25.2] |
| Fusion : Mitelman | IGH/LHX4 [14q32.33/1q25.2] |
| Fusion Portal | CCT8 21q21.3 LHX4 1q25.2 BRCA |
| Fusion : Quiver | LHX4 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | LHX4 [hg38] |
| dbVar | LHX4 |
| ClinVar | LHX4 |
| Monarch | LHX4 |
| 1000_Genomes | LHX4 |
| Exome Variant Server | LHX4 |
| GNOMAD Browser | ENSG00000121454 |
| Varsome Browser | LHX4 |
| Genomic Variants (DGV) | LHX4 [DGVbeta] |
| DECIPHER | LHX4 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | LHX4 |
| Mutations |
|---|
| ICGC Data Portal | LHX4 |
| TCGA Data Portal | LHX4 |
| Broad Tumor Portal | LHX4 |
| OASIS Portal | LHX4 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | LHX4 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | LHX4 |
| Mutations and Diseases : HGMD | LHX4 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search LHX4 |
| DgiDB (Drug Gene Interaction Database) | LHX4 |
| DoCM (Curated mutations) | LHX4 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | LHX4 (select a term) |
| intoGen | LHX4 |
| Cancer3D | LHX4(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 262700 602146 |
| Orphanet | 19033 11716 12620 12618 |
| DisGeNET | LHX4 |
| Medgen | LHX4 |
| Genetic Testing Registry | LHX4
|
| NextProt | Q969G2 [Medical] |
| GENETests | LHX4 |
| Target Validation | LHX4 |
| Huge Navigator |
LHX4 [HugePedia] |
| ClinGen | LHX4 (curated) |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | LHX4 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA134962876 |
| Pharos | Q969G2 |
| Clinical trial | LHX4 |
| Miscellaneous |
|---|
| canSAR (ICR) | LHX4 (select the gene name) |
| Harmonizome | LHX4 |
| DataMed Index | LHX4 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 40 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | LHX4 |
