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LHX4 (LIM homeobox 4)

Identity

Alias_symbol (synonym)Gsh4
Other aliasCPHD4
HGNC (Hugo) LHX4
LocusID (NCBI) 89884
Atlas_Id 41152
Location 1q25.2  [Link to chromosome band 1q25]
Location_base_pair Starts at 180230298 and ends at 180275053 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCT8 (21q21.3) / LHX4 (1q25.2)IGH (14q32.33) / LHX4 (1q25.2)IGHG1 (14q32.33) / LHX4 (1q25.2)
Ig () / LHX4 (1q25.2)LHX4 (1q25.2) / BRINP2 (1q25.2)LHX4 (1q25.2) / IGH (14q32.33)
LHX4 (1q25.2) / IGHG1 (14q32.33)CCT8 21q21.3 / LHX4 1q25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;14)(q25;q32) IGH/LHX4


External links

Nomenclature
HGNC (Hugo)LHX4   21734
Cards
Entrez_Gene (NCBI)LHX4  89884  LIM homeobox 4
AliasesCPHD4
GeneCards (Weizmann)LHX4
Ensembl hg19 (Hinxton)ENSG00000121454 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121454 [Gene_View]  chr1:180230298-180275053 [Contig_View]  LHX4 [Vega]
ICGC DataPortalENSG00000121454
TCGA cBioPortalLHX4
AceView (NCBI)LHX4
Genatlas (Paris)LHX4
WikiGenes89884
SOURCE (Princeton)LHX4
Genetics Home Reference (NIH)LHX4
Genomic and cartography
GoldenPath hg38 (UCSC)LHX4  -     chr1:180230298-180275053 +  1q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LHX4  -     1q25.2   [Description]    (hg19-Feb_2009)
EnsemblLHX4 - 1q25.2 [CytoView hg19]  LHX4 - 1q25.2 [CytoView hg38]
Mapping of homologs : NCBILHX4 [Mapview hg19]  LHX4 [Mapview hg38]
OMIM262700   602146   
Gene and transcription
Genbank (Entrez)AB037683 AB055703 AB055704 AF179849 AF282899
RefSeq transcript (Entrez)NM_033343
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LHX4
Cluster EST : UnigeneHs.658487 [ NCBI ]
CGAP (NCI)Hs.658487
Alternative Splicing GalleryENSG00000121454
Gene ExpressionLHX4 [ NCBI-GEO ]   LHX4 [ EBI - ARRAY_EXPRESS ]   LHX4 [ SEEK ]   LHX4 [ MEM ]
Gene Expression Viewer (FireBrowse)LHX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89884
GTEX Portal (Tissue expression)LHX4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969G2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969G2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969G2
Splice isoforms : SwissVarQ969G2
PhosPhoSitePlusQ969G2
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Znf_LIM   
Domain families : Pfam (Sanger)Homeobox (PF00046)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00046    pfam00412   
Domain families : Smart (EMBL)HOX (SM00389)  LIM (SM00132)  
Conserved Domain (NCBI)LHX4
DMDM Disease mutations89884
Blocks (Seattle)LHX4
PDB (SRS)5HOD   
PDB (PDBSum)5HOD   
PDB (IMB)5HOD   
PDB (RSDB)5HOD   
Structural Biology KnowledgeBase5HOD   
SCOP (Structural Classification of Proteins)5HOD   
CATH (Classification of proteins structures)5HOD   
SuperfamilyQ969G2
Human Protein AtlasENSG00000121454
Peptide AtlasQ969G2
HPRD03686
IPIIPI00169275   
Protein Interaction databases
DIP (DOE-UCLA)Q969G2
IntAct (EBI)Q969G2
FunCoupENSG00000121454
BioGRIDLHX4
STRING (EMBL)LHX4
ZODIACLHX4
Ontologies - Pathways
QuickGOQ969G2
Ontology : AmiGOplacenta development  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  motor neuron axon guidance  zinc ion binding  animal organ morphogenesis  medial motor column neuron differentiation  negative regulation of apoptotic process  sequence-specific DNA binding  
Ontology : EGO-EBIplacenta development  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  motor neuron axon guidance  zinc ion binding  animal organ morphogenesis  medial motor column neuron differentiation  negative regulation of apoptotic process  sequence-specific DNA binding  
NDEx NetworkLHX4
Atlas of Cancer Signalling NetworkLHX4
Wikipedia pathwaysLHX4
Orthology - Evolution
OrthoDB89884
GeneTree (enSembl)ENSG00000121454
Phylogenetic Trees/Animal Genes : TreeFamLHX4
HOVERGENQ969G2
HOGENOMQ969G2
Homologs : HomoloGeneLHX4
Homology/Alignments : Family Browser (UCSC)LHX4
Gene fusions - Rearrangements
Fusion : MitelmanCCT8/LHX4 [21q21.3/1q25.2]  [t(1;21)(q25;q21)]  
Fusion : MitelmanIGH/LHX4 [14q32.33/1q25.2]  [t(1;14)(q25;q32)]  
Fusion: TCGACCT8 21q21.3 LHX4 1q25.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLHX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LHX4
dbVarLHX4
ClinVarLHX4
1000_GenomesLHX4 
Exome Variant ServerLHX4
ExAC (Exome Aggregation Consortium)LHX4 (select the gene name)
Genetic variants : HAPMAP89884
Genomic Variants (DGV)LHX4 [DGVbeta]
DECIPHERLHX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLHX4 
Mutations
ICGC Data PortalLHX4 
TCGA Data PortalLHX4 
Broad Tumor PortalLHX4
OASIS PortalLHX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLHX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLHX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LHX4
DgiDB (Drug Gene Interaction Database)LHX4
DoCM (Curated mutations)LHX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LHX4 (select a term)
intoGenLHX4
Cancer3DLHX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM262700    602146   
Orphanet19033    11716    12620    12618   
MedgenLHX4
Genetic Testing Registry LHX4
NextProtQ969G2 [Medical]
TSGene89884
GENETestsLHX4
Target ValidationLHX4
Huge Navigator LHX4 [HugePedia]
snp3D : Map Gene to Disease89884
BioCentury BCIQLHX4
ClinGenLHX4 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89884
Chemical/Pharm GKB GenePA134962876
Clinical trialLHX4
Miscellaneous
canSAR (ICR)LHX4 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLHX4
EVEXLHX4
GoPubMedLHX4
iHOPLHX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:40:31 CEST 2017

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