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LIAS (lipoic acid synthetase)

Identity

Alias_symbol (synonym)LAS
Other aliasHGCLAS
HUSSY-01
LIP1
LS
PDHLD
HGNC (Hugo) LIAS
LocusID (NCBI) 11019
Atlas_Id 65259
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 39459024 and ends at 39477651 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RPL9 (4p14) / LIAS (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

8Td WIDTH=15%>Genetics Home Reference (NIH)
Nomenclature
HGNC (Hugo)LIAS   16429
C!rds<TH?
Entrez_Gene (NCBI)LIAS  11019  lipoic acid synthetase
AliasesHGCLAS; HUSSY-01; LAS; LIP1; 
LS; PDHLD
GeneCards (Weizmann)LIAS
Ensembl hg19 (Hinxton)ENSG00000121897 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121897 [Gene_View]  chr4:39459024-39477651 [Contig_View]  LIAS [Vega]
ICGC DataPortalENSG00000121897
TCGA cBioPortalLIAS
AceView (NCBI)LIAS
Genatlas (Paris)LIAS
WikiGenes11019
SOURCE (Princeton)LIAS
LIAS
Genomic and cartography
GoldenPath hg38 (UCSC)LIAS  -     chr4:39459024-39477651 +  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LIAS  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblLIAS - 4p14 [CytoView hg19]  LIAS - 4p14 [CytoView hg38]
Mapping of homologs : NCBILIAS [Mapview hg19]  LIAS [Mapview hg38]
OMIM607031   614462   
Gene and transcription
Genbank (Entrez)AI373464 AJ224162 AK026289 AK291985 AK292238
RefSeq transcript (Entrez)NM_001278590 NM_001278591 NM_001278592 NM_006859 NM_194451
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LIAS
Cluster EST : UnigeneHs.550502 [ NCBI ]
CGAP (NCI)Hs.550502
Alternative Splicing GalleryENSG00000121897
Gene ExpressionLIAS [ NCBI-GEO ]   LIAS [ EBI - ARRAY_EXPRESS ]   LIAS [ SEEK ]   LIAS [ MEM ]
Gene Expression Viewer (FireBrowse)LIAS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11019
GTEX Portal (Tissue expression)LIAS
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43766   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43766  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43766
Splice isoforms : SwissVarO43766
PhosPhoSitePlusO43766
Domains : Interpro (EBI)Aldolase_TIM    Elp3/MiaB/NifB    LIAS_N    Lipoyl_synth    rSAM   
Domain families : Pfam (Sanger)LIAS_N (PF16881)    Radical_SAM (PF04055)   
Domain families : Pfam (NCBI)pfam16881    pfam04055   
Domain families : Smart (EMBL)Elp3 (SM00729)  
Conserved Domain (NCBI)LIAS
DMDM Disease mutations11019
Blocks (Seattle)LIAS
SuperfamilyO43766
Human Protein AtlasENSG00000121897
Peptide AtlasO43766
HPRD09514
IPIIPI00216886   IPI00909832   IPI00441029   IPI00657781   IPI00964806   IPI00375721   
Protein Interaction databases
DIP (DOE-UCLA)O43766
IntAct (EBI)O43766
FunCoupENSG00000121897
BioGRIDLIAS
STRING (EMBL)LIAS
ZODIACLIAS
Ontologies - Pathways
QuickGOO43766
Ontology : AmiGOmitochondrion  mitochondrial matrix  inflammatory response  response to oxidative stress  lipoate biosynthetic process  lipoate synthase activity  lipoate synthase activity  response to lipopolysaccharide  glyoxylate metabolic process  metal ion binding  4 iron, 4 sulfur cluster binding  
Ontology : EGO-EBImitochondrion  mitochondrial matrix  inflammatory response  response to oxidative stress  lipoate biosynthetic process  lipoate synthase activity  lipoate synthase activity  response to lipopolysaccharide  glyoxylate metabolic process  metal ion binding  4 iron, 4 sulfur cluster binding  
Pathways : KEGGLipoic acid metabolism   
NDEx NetworkLIAS
Atlas of Cancer Signalling NetworkLIAS
Wikipedia pathwaysLIAS
Orthology - Evolution
OrthoDB11019
GeneTree (enSembl)ENSG00000121897
Phylogenetic Trees/Animal Genes : TreeFamLIAS
HOVERGENO43766
HOGENOMO43766
Homologs : HomoloGeneLIAS
Homology/Alignments : Family Browser (UCSC)LIAS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIAS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIAS
dbVarLIAS
ClinVarLIAS
1000_GenomesLIAS 
Exome Variant ServerLIAS
ExAC (Exome Aggregation Consortium)LIAS (select the gene name)
Genetic variants : HAPMAP11019
Genomic Variants (DGV)LIAS [DGVbeta]
DECIPHERLIAS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLIAS 
Mutations
ICGC Data PortalLIAS 
TCGA Data PortalLIAS 
Broad Tumor PortalLIAS
OASIS PortalLIAS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIAS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLIAS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LIAS
DgiDB (Drug Gene Interaction Database)LIAS
DoCM (Curated mutations)LIAS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIAS (select a term)
intoGenLIAS
Cancer3DLIAS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607031    614462   
Orphanet22842   
MedgenLIAS
Genetic Testing Registry LIAS
NextProtO43766 [Medical]
TSGene11019
GENETestsLIAS
Target ValidationLIAS
Huge Navigator LIAS [HugePedia]
snp3D : Map Gene to Disease11019
BioCentury BCIQLIAS
ClinGenLIAS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11019
Chemical/Pharm GKB GenePA30369
Clinical trialLIAS
Miscellaneous
canSAR (ICR)LIAS (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIAS
EVEXLIAS
GoPubMedLIAS
iHOPLIAS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:12:41 CEST 2017

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