LIF (leukemia inhibitory factor (cholinergic differentiation factor))

Identity

Other names	CDF
	D-FACTOR
	HILDA
HGNC	LIF
Location	22q12.2
Location_base_pair	Starts at 28966443 and ends at 28972748 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	LIF   6596
Entrez_Gene	LIF  3976  leukemia inhibitory factor (cholinergic differentiation factor)
	Cards
GeneCards	LIF
Ensembl	LIF [Search_View]   ENSG00000128342 [Gene_View]
Genatlas	LIF
GeneLynx	LIF
eGenome	LIF
euGene	3976
	Genomic and cartography
GoldenPath	LIF  -  22q12.2   chr22:28966443-28972748 -  22q12.2   [Description]    (hg18-March_2006)
Ensembl	LIF - 22q12.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	LIF
	Gene and transcription
Genbank	AK315310 [ ENTREZ ]
Genbank	BC069540 [ ENTREZ ]
Genbank	BC093733 [ ENTREZ ]
Genbank	BC093735 [ ENTREZ ]
Genbank	X13967 [ ENTREZ ]
RefSeq	NM_002309 [ SRS ]    NM_002309 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011520 [ SRS ]    NT_011520 [ ENTREZ ]
RefSeq	NW_001838745 [ SRS ]    NW_001838745 [ ENTREZ ]
RefSeq	NW_927628 [ SRS ]    NW_927628 [ ENTREZ ]
AceView	LIF AceView - NCBI
Unigene	Hs.2250 [ SRS ]    Hs.2250 [ NCBI ]     HS2250 [ spliceNest ]
Fast-db	4148 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P15018 [ SRS]    P15018 [ EXPASY ]     P15018 [ INTERPRO ]     P15018 [ UNIPROT ]
Prosite	PS00590 LIF_OSM [ SRS ]    PS00590 LIF_OSM [ Expasy ]
Interpro	IPR012351 4_helix_cytokine_core [ SRS ]    IPR012351 4_helix_cytokine_core [ EBI ]
Interpro	IPR003624 LIF [ SRS ]    IPR003624 LIF [ EBI ]
Interpro	IPR001581 LIF_OSM [ SRS ]    IPR001581 LIF_OSM [ EBI ]
CluSTr	P15018
Pfam	PF01291 LIF_OSM [ SRS ]    PF01291 LIF_OSM [ Sanger ]    pfam01291 [ NCBI-CDD ]
Smart	SM00080 LIF_OSM [EMBL]
Prodom	PD011266 LIF[INRA-Toulouse]
Prodom	P15018 LIF_HUMAN [ Domain structure ]   P15018 LIF_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P15018
PDB	1A7M [ SRS ]    1A7M [ PdbSum ],   1A7M [ IMB ]   1A7M [ RSDB ]
PDB	1EMR [ SRS ]    1EMR [ PdbSum ],   1EMR [ IMB ]   1EMR [ RSDB ]
PDB	1PVH [ SRS ]    1PVH [ PdbSum ],   1PVH [ IMB ]   1PVH [ RSDB ]
PDB	2Q7N [ SRS ]    2Q7N [ PdbSum ],   2Q7N [ IMB ]   2Q7N [ RSDB ]
HPRD	08869
	Protein Interaction databases
DIP	P15018
IntAct	P15018
	Polymorphism : SNP, mutations, diseases
OMIM	159540    [ map ]
GENECLINICS	159540
SNP	LIF [dbSNP-NCBI]
SNP	NM_002309 [SNP-NCI]
SNP	LIF [GeneSNPs - Utah]  LIF] [HGBASE - SRS]
HAPMAP	LIF [HAPMAP]
COSMIC	LIF [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	LIF
	General knowledge
Family Browser	LIF [UCSC Family Browser]
SOURCE	NM_002309
SMD	Hs.2250
SAGE	Hs.2250
GO	cytokine activity [Amigo]  cytokine activity
GO	leukemia inhibitory factor receptor binding [Amigo]  leukemia inhibitory factor receptor binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	immune response [Amigo]  immune response
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	growth factor activity [Amigo]  growth factor activity
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	organ regeneration [Amigo]  organ regeneration
GO	positive regulation of peptidyl-serine phosphorylation [Amigo]  positive regulation of peptidyl-serine phosphorylation
GO	positive regulation of MAPKKK cascade [Amigo]  positive regulation of MAPKKK cascade
GO	positive regulation of macrophage differentiation [Amigo]  positive regulation of macrophage differentiation
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
GO	negative regulation of hormone secretion [Amigo]  negative regulation of hormone secretion
GO	positive regulation of peptidyl-tyrosine phosphorylation [Amigo]  positive regulation of peptidyl-tyrosine phosphorylation
BIOCARTA	NFAT and Hypertrophy of the heart (Transcription in the broken heart)    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	Jak-STAT signaling pathway
PubGene	LIF
TreeFam	LIF
CTD	3976 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	LIF Related clones (RZPD - Berlin)
	PubMed
PubMed	69 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:19:42 2008