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LIF (leukemia inhibitory factor)

Identity

Other namesCDF
DIA
HILDA
MLPLI
HGNC (Hugo) LIF
LocusID (NCBI) 3976
Atlas_Id 41153
Location 22q12.2
Location_base_pair Starts at 30636436 and ends at 30642840 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LIF (22q12.2) / HLA-C (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIF   6596
Cards
Entrez_Gene (NCBI)LIF  3976  leukemia inhibitory factor
GeneCards (Weizmann)LIF
Ensembl hg19 (Hinxton)ENSG00000128342 [Gene_View]  chr22:30636436-30642840 [Contig_View]  LIF [Vega]
Ensembl hg38 (Hinxton)ENSG00000128342 [Gene_View]  chr22:30636436-30642840 [Contig_View]  LIF [Vega]
ICGC DataPortalENSG00000128342
TCGA cBioPortalLIF
AceView (NCBI)LIF
Genatlas (Paris)LIF
WikiGenes3976
SOURCE (Princeton)LIF
Genomic and cartography
GoldenPath hg19 (UCSC)LIF  -     chr22:30636436-30642840 -  22q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIF  -     22q12.2   [Description]    (hg38-Dec_2013)
EnsemblLIF - 22q12.2 [CytoView hg19]  LIF - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBILIF [Mapview hg19]  LIF [Mapview hg38]
OMIM159540   
Gene and transcription
Genbank (Entrez)AI796373 AK315310 BC069540 BC093733 BC093735
RefSeq transcript (Entrez)NM_001257135 NM_002309
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_008721 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)LIF
Cluster EST : UnigeneHs.2250 [ NCBI ]
CGAP (NCI)Hs.2250
Alternative Splicing : Fast-db (Paris)GSHG0020296
Alternative Splicing GalleryENSG00000128342
Gene ExpressionLIF [ NCBI-GEO ]   LIF [ EBI - ARRAY_EXPRESS ]   LIF [ SEEK ]   LIF [ MEM ]
Gene Expression Viewer (FireBrowse)LIF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3976
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15018 (Uniprot)
NextProtP15018  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15018
Splice isoforms : SwissVarP15018 (Swissvar)
PhosPhoSitePlusP15018
Domaine pattern : Prosite (Expaxy)LIF_OSM (PS00590)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Leukemia_IF    Leukemia_IF/oncostatin    Leukemia_IF/oncostatin_CS   
Domain families : Pfam (Sanger)LIF_OSM (PF01291)   
Domain families : Pfam (NCBI)pfam01291   
Domain families : Smart (EMBL)LIF_OSM (SM00080)  
DMDM Disease mutations3976
Blocks (Seattle)LIF
PDB (SRS)1EMR    1PVH    2Q7N   
PDB (PDBSum)1EMR    1PVH    2Q7N   
PDB (IMB)1EMR    1PVH    2Q7N   
PDB (RSDB)1EMR    1PVH    2Q7N   
Structural Biology KnowledgeBase1EMR    1PVH    2Q7N   
SCOP (Structural Classification of Proteins)1EMR    1PVH    2Q7N   
CATH (Classification of proteins structures)1EMR    1PVH    2Q7N   
SuperfamilyP15018
Human Protein AtlasENSG00000128342
Peptide AtlasP15018
HPRD08869
IPIIPI00009720   IPI00877832   
Protein Interaction databases
DIP (DOE-UCLA)P15018
IntAct (EBI)P15018
FunCoupENSG00000128342
BioGRIDLIF
STRING (EMBL)LIF
ZODIACLIF
Ontologies - Pathways
QuickGOP15018
Ontology : AmiGOtranscription factor activity, RNA polymerase II transcription factor recruiting  blood vessel remodeling  receptor binding  cytokine activity  leukemia inhibitory factor receptor binding  leukemia inhibitory factor receptor binding  extracellular region  extracellular space  cytoplasm  immune response  multicellular organism development  embryo implantation  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  positive regulation of neuron projection development  negative regulation of angiogenesis  stem cell population maintenance  organ regeneration  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation of STAT protein  tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of MAPK cascade  positive regulation of macrophage differentiation  negative regulation of meiotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  decidualization  negative regulation of hormone secretion  lung alveolus development  muscle organ morphogenesis  neuron development  astrocyte differentiation  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  stem cell differentiation  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of corticotropin secretion  retina development in camera-type eye  transdifferentiation  lung vasculature development  lung lobe morphogenesis  trophoblast giant cell differentiation  spongiotrophoblast differentiation  negative regulation of ERK1 and ERK2 cascade  positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  regulation of metanephric nephron tubule epithelial cell differentiation  positive regulation of protein localization to nucleus  positive regulation of histone H3-K27 acetylation  regulation of RNA polymerase II regulatory region sequence-specific DNA binding  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II transcription factor recruiting  blood vessel remodeling  receptor binding  cytokine activity  leukemia inhibitory factor receptor binding  leukemia inhibitory factor receptor binding  extracellular region  extracellular space  cytoplasm  immune response  multicellular organism development  embryo implantation  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  positive regulation of neuron projection development  negative regulation of angiogenesis  stem cell population maintenance  organ regeneration  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation of STAT protein  tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of MAPK cascade  positive regulation of macrophage differentiation  negative regulation of meiotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  decidualization  negative regulation of hormone secretion  lung alveolus development  muscle organ morphogenesis  neuron development  astrocyte differentiation  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  stem cell differentiation  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of corticotropin secretion  retina development in camera-type eye  transdifferentiation  lung vasculature development  lung lobe morphogenesis  trophoblast giant cell differentiation  spongiotrophoblast differentiation  negative regulation of ERK1 and ERK2 cascade  positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  regulation of metanephric nephron tubule epithelial cell differentiation  positive regulation of protein localization to nucleus  positive regulation of histone H3-K27 acetylation  regulation of RNA polymerase II regulatory region sequence-specific DNA binding  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    TNF signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkLIF
Wikipedia pathwaysLIF
Orthology - Evolution
OrthoDB3976
GeneTree (enSembl)ENSG00000128342
Phylogenetic Trees/Animal Genes : TreeFamLIF
Homologs : HomoloGeneLIF
Homology/Alignments : Family Browser (UCSC)LIF
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLIF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIF
dbVarLIF
ClinVarLIF
1000_GenomesLIF 
Exome Variant ServerLIF
ExAC (Exome Aggregation Consortium)LIF (select the gene name)
SNP (GeneSNP Utah)LIF
SNP : HGBaseLIF
Genetic variants : HAPMAPLIF
Genomic Variants (DGV)LIF [DGVbeta]
Mutations
ICGC Data PortalLIF 
TCGA Data PortalLIF 
Broad Tumor PortalLIF
OASIS PortalLIF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIF 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LIF
DgiDB (Drug Gene Interaction Database)LIF
DoCM (Curated mutations)LIF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIF (select a term)
intoGenLIF
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:30636436-30642840
CONAN: Copy Number AnalysisLIF 
Mutations and Diseases : HGMDLIF
OMIM159540   
MedgenLIF
Genetic Testing Registry LIF
NextProtP15018 [Medical]
TSGene3976
GENETestsLIF
Huge Navigator LIF [HugePedia]  LIF [HugeCancerGEM]
snp3D : Map Gene to Disease3976
BioCentury BCIQLIF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3976
Chemical/Pharm GKB GenePA30370
Clinical trialLIF
Miscellaneous
canSAR (ICR)LIF (select the gene name)
Probes
Litterature
PubMed171 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIF
GoPubMedLIF
iHOPLIF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:51:00 CEST 2016

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