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LIF (leukemia inhibitory factor)

Identity

Other namesCDF
DIA
HILDA
MLPLI
HGNC (Hugo) LIF
LocusID (NCBI) 3976
Location 22q12.2
Location_base_pair Starts at 30636436 and ends at 30642840 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LIF   6596
Cards
Entrez_Gene (NCBI)LIF  3976  leukemia inhibitory factor
GeneCards (Weizmann)LIF
Ensembl (Hinxton)ENSG00000128342 [Gene_View]  chr22:30636436-30642840 [Contig_View]  LIF [Vega]
AceView (NCBI)LIF
Genatlas (Paris)LIF
WikiGenes3976
SOURCE (Princeton)NM_001257135 NM_002309
Genomic and cartography
GoldenPath (UCSC)LIF  -  22q12.2   chr22:30636436-30642840 -  22q12.2   [Description]    (hg19-Feb_2009)
EnsemblLIF - 22q12.2 [CytoView]
Mapping of homologs : NCBILIF [Mapview]
OMIM159540   
Gene and transcription
Genbank (Entrez)AI796373 AK315310 BC069540 BC093733 BC093735
RefSeq transcript (Entrez)NM_001257135 NM_002309
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_008721 NT_011520 NW_001838745 NW_004929430
Consensus coding sequences : CCDS (NCBI)LIF
Cluster EST : UnigeneHs.2250 [ NCBI ]
CGAP (NCI)Hs.2250
Alternative Splicing : Fast-db (Paris)GSHG0020296
Alternative Splicing GalleryENSG00000128342
Gene ExpressionLIF [ NCBI-GEO ]     LIF [ SEEK ]   LIF [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15018 (Uniprot)
NextProtP15018  [Medical]
With graphics : InterProP15018
Splice isoforms : SwissVarP15018 (Swissvar)
Domaine pattern : Prosite (Expaxy)LIF_OSM (PS00590)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Leukemia_IF    Leukemia_IF/oncostatin    Leukemia_IF/oncostatin_CS   
Related proteins : CluSTrP15018
Domain families : Pfam (Sanger)LIF_OSM (PF01291)   
Domain families : Pfam (NCBI)pfam01291   
Domain families : Smart (EMBL)LIF_OSM (SM00080)  
DMDM Disease mutations3976
Blocks (Seattle)P15018
PDB (SRS)1EMR    1PVH    2Q7N   
PDB (PDBSum)1EMR    1PVH    2Q7N   
PDB (IMB)1EMR    1PVH    2Q7N   
PDB (RSDB)1EMR    1PVH    2Q7N   
Human Protein AtlasENSG00000128342
Peptide AtlasP15018
HPRD08869
IPIIPI00009720   IPI00877832   
Protein Interaction databases
DIP (DOE-UCLA)P15018
IntAct (EBI)P15018
FunCoupENSG00000128342
BioGRIDLIF
InParanoidP15018
Interologous Interaction database P15018
IntegromeDBLIF
STRING (EMBL)LIF
Ontologies - Pathways
Ontology : AmiGORNA polymerase II transcription factor recruiting transcription factor activity  blood vessel remodeling  receptor binding  cytokine activity  leukemia inhibitory factor receptor binding  leukemia inhibitory factor receptor binding  extracellular space  cytoplasm  immune response  multicellular organismal development  embryo implantation  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  stem cell maintenance  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation of STAT protein  tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of MAPK cascade  positive regulation of macrophage differentiation  negative regulation of meiosis  positive regulation of transcription from RNA polymerase II promoter  decidualization  negative regulation of hormone secretion  lung alveolus development  muscle organ morphogenesis  neuron development  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  lung vasculature development  lung lobe morphogenesis  trophoblast giant cell differentiation  spongiotrophoblast differentiation  negative regulation of ERK1 and ERK2 cascade  positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  regulation of metanephric nephron tubule epithelial cell differentiation  positive regulation of protein localization to nucleus  positive regulation of histone H3-K27 acetylation  
Ontology : EGO-EBIRNA polymerase II transcription factor recruiting transcription factor activity  blood vessel remodeling  receptor binding  cytokine activity  leukemia inhibitory factor receptor binding  leukemia inhibitory factor receptor binding  extracellular space  cytoplasm  immune response  multicellular organismal development  embryo implantation  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  stem cell maintenance  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation of STAT protein  tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of MAPK cascade  positive regulation of macrophage differentiation  negative regulation of meiosis  positive regulation of transcription from RNA polymerase II promoter  decidualization  negative regulation of hormone secretion  lung alveolus development  muscle organ morphogenesis  neuron development  positive regulation of astrocyte differentiation  leukemia inhibitory factor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  lung vasculature development  lung lobe morphogenesis  trophoblast giant cell differentiation  spongiotrophoblast differentiation  negative regulation of ERK1 and ERK2 cascade  positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  regulation of metanephric nephron tubule epithelial cell differentiation  positive regulation of protein localization to nucleus  positive regulation of histone H3-K27 acetylation  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    TNF signaling pathway   
REACTOMELIF
Protein Interaction DatabaseLIF
Wikipedia pathwaysLIF
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LIF
SNP (GeneSNP Utah)LIF
SNP : HGBaseLIF
Genetic variants : HAPMAPLIF
1000_GenomesLIF 
ICGC programENSG00000128342 
Somatic Mutations in Cancer : COSMICLIF 
CONAN: Copy Number AnalysisLIF 
Mutations and Diseases : HGMDLIF
OMIM159540   
GENETestsLIF
Disease Genetic AssociationLIF
Huge Navigator LIF [HugePedia]  LIF [HugeCancerGEM]
Genomic VariantsLIF  LIF [DGVbeta]
Exome VariantLIF
dbVarLIF
ClinVarLIF
snp3D : Map Gene to Disease3976
General knowledge
Homologs : HomoloGeneLIF
Homology/Alignments : Family Browser (UCSC)LIF
Phylogenetic Trees/Animal Genes : TreeFamLIF
Chemical/Protein Interactions : CTD3976
Chemical/Pharm GKB GenePA30370
Clinical trialLIF
Cancer Resource (Charite)ENSG00000128342
Other databases
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
CoreMineLIF
iHOPLIF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:09:26 CEST 2014

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