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LIG1 (ligase I, DNA, ATP-dependent)

Identity

Other names-
HGNC (Hugo) LIG1
LocusID (NCBI) 3978
Location 19q13.33
Location_base_pair Starts at 48618702 and ends at 48673860 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LIG1   6598
Cards
Entrez_Gene (NCBI)LIG1  3978  ligase I, DNA, ATP-dependent
GeneCards (Weizmann)LIG1
Ensembl (Hinxton)ENSG00000105486 [Gene_View]  chr19:48618702-48673860 [Contig_View]  LIG1 [Vega]
ICGC DataPortalENSG00000105486
AceView (NCBI)LIG1
Genatlas (Paris)LIG1
WikiGenes3978
SOURCE (Princeton)NM_000234 NM_001289063 NM_001289064
Genomic and cartography
GoldenPath (UCSC)LIG1  -  19q13.33   chr19:48618702-48673860 -  19q13.33   [Description]    (hg19-Feb_2009)
EnsemblLIG1 - 19q13.33 [CytoView]
Mapping of homologs : NCBILIG1 [Mapview]
OMIM126391   
Gene and transcription
Genbank (Entrez)AB208791 AK225863 AK297296 AK300370 AK300607
RefSeq transcript (Entrez)NM_000234 NM_001289063 NM_001289064
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_007395 NT_011109 NW_001838497 NW_004929415
Consensus coding sequences : CCDS (NCBI)LIG1
Cluster EST : UnigeneHs.1770 [ NCBI ]
CGAP (NCI)Hs.1770
Alternative Splicing : Fast-db (Paris)GSHG0015962
Alternative Splicing GalleryENSG00000105486
Gene ExpressionLIG1 [ NCBI-GEO ]     LIG1 [ SEEK ]   LIG1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18858 (Uniprot)
NextProtP18858  [Medical]
With graphics : InterProP18858
Splice isoforms : SwissVarP18858 (Swissvar)
Catalytic activity : Enzyme6.5.1.1 [ Enzyme-Expasy ]   6.5.1.16.5.1.1 [ IntEnz-EBI ]   6.5.1.1 [ BRENDA ]   6.5.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DNA_LIGASE_A1 (PS00697)    DNA_LIGASE_A2 (PS00333)    DNA_LIGASE_A3 (PS50160)   
Domains : Interpro (EBI)DNA_ligase_ATP-dep    DNA_ligase_ATP-dep_C    DNA_ligase_ATP-dep_cent    DNA_ligase_ATP-dep_CS    DNA_ligase_ATP-dep_N    NA-bd_OB-fold   
Related proteins : CluSTrP18858
Domain families : Pfam (Sanger)DNA_ligase_A_C (PF04679)    DNA_ligase_A_M (PF01068)    DNA_ligase_A_N (PF04675)   
Domain families : Pfam (NCBI)pfam04679    pfam01068    pfam04675   
DMDM Disease mutations3978
Blocks (Seattle)P18858
PDB (SRS)1X9N   
PDB (PDBSum)1X9N   
PDB (IMB)1X9N   
PDB (RSDB)1X9N   
Human Protein AtlasENSG00000105486
Peptide AtlasP18858
HPRD00534
IPIIPI00219841   IPI01011603   IPI01011052   IPI01010243   IPI01010750   
Protein Interaction databases
DIP (DOE-UCLA)P18858
IntAct (EBI)P18858
FunCoupENSG00000105486
BioGRIDLIG1
IntegromeDBLIG1
STRING (EMBL)LIG1
Ontologies - Pathways
QuickGOP18858
Ontology : AmiGOmitotic cell cycle  telomere maintenance via recombination  telomere maintenance  double-strand break repair via homologous recombination  DNA binding  DNA ligase activity  DNA ligase (ATP) activity  ATP binding  nucleus  nucleus  nucleoplasm  chromosome  nucleolus  mitochondrion  Golgi apparatus  DNA metabolic process  DNA strand elongation involved in DNA replication  lagging strand elongation  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, DNA gap filling  double-strand break repair  double-strand break repair via nonhomologous end joining  anatomical structure morphogenesis  telomere maintenance via semi-conservative replication  V(D)J recombination  response to hydrogen peroxide  intracellular membrane-bounded organelle  metal ion binding  DNA ligation involved in DNA repair  cell division  
Ontology : EGO-EBImitotic cell cycle  telomere maintenance via recombination  telomere maintenance  double-strand break repair via homologous recombination  DNA binding  DNA ligase activity  DNA ligase (ATP) activity  ATP binding  nucleus  nucleus  nucleoplasm  chromosome  nucleolus  mitochondrion  Golgi apparatus  DNA metabolic process  DNA strand elongation involved in DNA replication  lagging strand elongation  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, DNA gap filling  double-strand break repair  double-strand break repair via nonhomologous end joining  anatomical structure morphogenesis  telomere maintenance via semi-conservative replication  V(D)J recombination  response to hydrogen peroxide  intracellular membrane-bounded organelle  metal ion binding  DNA ligation involved in DNA repair  cell division  
Pathways : KEGGDNA replication    Base excision repair    Nucleotide excision repair    Mismatch repair   
Protein Interaction DatabaseLIG1
Wikipedia pathwaysLIG1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LIG1
SNP (GeneSNP Utah)LIG1
SNP : HGBaseLIG1
Genetic variants : HAPMAPLIG1
1000_GenomesLIG1 
ICGC programENSG00000105486 
CONAN: Copy Number AnalysisLIG1 
Somatic Mutations in Cancer : COSMICLIG1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)19:48618702-48673860
Mutations and Diseases : HGMDLIG1
OMIM126391   
MedgenLIG1
GENETestsLIG1
Disease Genetic AssociationLIG1
Huge Navigator LIG1 [HugePedia]  LIG1 [HugeCancerGEM]
Genomic VariantsLIG1  LIG1 [DGVbeta]
Exome VariantLIG1
dbVarLIG1
ClinVarLIG1
snp3D : Map Gene to Disease3978
General knowledge
Homologs : HomoloGeneLIG1
Homology/Alignments : Family Browser (UCSC)LIG1
Phylogenetic Trees/Animal Genes : TreeFamLIG1
Chemical/Protein Interactions : CTD3978
Chemical/Pharm GKB GenePA30372
Clinical trialLIG1
Cancer Resource (Charite)ENSG00000105486
Other databases
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
CoreMineLIG1
GoPubMedLIG1
iHOPLIG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:37:11 CET 2014

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