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LIG1 (ligase I, DNA, ATP-dependent)

Identity

Other names-
HGNC (Hugo) LIG1
LocusID (NCBI) 3978
Atlas_Id 41154
Location 19q13.33
Location_base_pair Starts at 48618702 and ends at 48673860 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LIG1   6598
Cards
Entrez_Gene (NCBI)LIG1  3978  ligase I, DNA, ATP-dependent
GeneCards (Weizmann)LIG1
Ensembl hg19 (Hinxton)ENSG00000105486 [Gene_View]  chr19:48618702-48673860 [Contig_View]  LIG1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000105486 [Gene_View]  chr19:48618702-48673860 [Contig_View]  LIG1 [Vega]
ICGC DataPortalENSG00000105486
TCGA cBioPortalLIG1
AceView (NCBI)LIG1
Genatlas (Paris)LIG1
WikiGenes3978
SOURCE (Princeton)LIG1
Genomic and cartography
GoldenPath hg19 (UCSC)LIG1  -     chr19:48618702-48673860 -  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIG1  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblLIG1 - 19q13.33 [CytoView hg19]  LIG1 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBILIG1 [Mapview hg19]  LIG1 [Mapview hg38]
OMIM126391   
Gene and transcription
Genbank (Entrez)AB208791 AK225863 AK297296 AK300370 AK300607
RefSeq transcript (Entrez)NM_000234 NM_001289063 NM_001289064
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_007395 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)LIG1
Cluster EST : UnigeneHs.1770 [ NCBI ]
CGAP (NCI)Hs.1770
Alternative Splicing : Fast-db (Paris)GSHG0015962
Alternative Splicing GalleryENSG00000105486
Gene ExpressionLIG1 [ NCBI-GEO ]     LIG1 [ SEEK ]   LIG1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18858 (Uniprot)
NextProtP18858  [Medical]
With graphics : InterProP18858
Splice isoforms : SwissVarP18858 (Swissvar)
Catalytic activity : Enzyme6.5.1.1 [ Enzyme-Expasy ]   6.5.1.16.5.1.1 [ IntEnz-EBI ]   6.5.1.1 [ BRENDA ]   6.5.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DNA_LIGASE_A1 (PS00697)    DNA_LIGASE_A2 (PS00333)    DNA_LIGASE_A3 (PS50160)   
Domains : Interpro (EBI)DNA_ligase_ATP-dep    DNA_ligase_ATP-dep_C    DNA_ligase_ATP-dep_cent    DNA_ligase_ATP-dep_CS    DNA_ligase_ATP-dep_N    NA-bd_OB-fold   
Related proteins : CluSTrP18858
Domain families : Pfam (Sanger)DNA_ligase_A_C (PF04679)    DNA_ligase_A_M (PF01068)    DNA_ligase_A_N (PF04675)   
Domain families : Pfam (NCBI)pfam04679    pfam01068    pfam04675   
DMDM Disease mutations3978
Blocks (Seattle)P18858
PDB (SRS)1X9N   
PDB (PDBSum)1X9N   
PDB (IMB)1X9N   
PDB (RSDB)1X9N   
Human Protein AtlasENSG00000105486
Peptide AtlasP18858
HPRD00534
IPIIPI00219841   IPI01011603   IPI01011052   IPI01010243   IPI01010750   
Protein Interaction databases
DIP (DOE-UCLA)P18858
IntAct (EBI)P18858
FunCoupENSG00000105486
BioGRIDLIG1
IntegromeDBLIG1
STRING (EMBL)LIG1
Ontologies - Pathways
QuickGOP18858
Ontology : AmiGOmitotic cell cycle  telomere maintenance via recombination  telomere maintenance  double-strand break repair via homologous recombination  DNA binding  DNA ligase activity  DNA ligase activity  DNA ligase (ATP) activity  ATP binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  Golgi apparatus  DNA metabolic process  DNA ligation  DNA ligation  DNA ligation  DNA strand elongation involved in DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair  nucleotide-excision repair  nucleotide-excision repair, DNA gap filling  mismatch repair  double-strand break repair  double-strand break repair via nonhomologous end joining  anatomical structure morphogenesis  telomere maintenance via semi-conservative replication  V(D)J recombination  response to hydrogen peroxide  intracellular membrane-bounded organelle  metal ion binding  DNA ligation involved in DNA repair  cell division  DNA biosynthetic process  Okazaki fragment processing involved in mitotic DNA replication  removal of RNA primer involved in mitotic DNA replication  
Ontology : EGO-EBImitotic cell cycle  telomere maintenance via recombination  telomere maintenance  double-strand break repair via homologous recombination  DNA binding  DNA ligase activity  DNA ligase activity  DNA ligase (ATP) activity  ATP binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  Golgi apparatus  DNA metabolic process  DNA ligation  DNA ligation  DNA ligation  DNA strand elongation involved in DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair  nucleotide-excision repair  nucleotide-excision repair, DNA gap filling  mismatch repair  double-strand break repair  double-strand break repair via nonhomologous end joining  anatomical structure morphogenesis  telomere maintenance via semi-conservative replication  V(D)J recombination  response to hydrogen peroxide  intracellular membrane-bounded organelle  metal ion binding  DNA ligation involved in DNA repair  cell division  DNA biosynthetic process  Okazaki fragment processing involved in mitotic DNA replication  removal of RNA primer involved in mitotic DNA replication  
Pathways : KEGGDNA replication    Base excision repair    Nucleotide excision repair    Mismatch repair   
Protein Interaction DatabaseLIG1
DoCM (Curated mutations)LIG1
Wikipedia pathwaysLIG1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerLIG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIG1
dbVarLIG1
ClinVarLIG1
1000_GenomesLIG1 
Exome Variant ServerLIG1
SNP (GeneSNP Utah)LIG1
SNP : HGBaseLIG1
Genetic variants : HAPMAPLIG1
Genomic Variants (DGV)LIG1 [DGVbeta]
Mutations
ICGC Data PortalLIG1 
TCGA Data PortalLIG1 
Tumor PortalLIG1
Somatic Mutations in Cancer : COSMICLIG1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:48618702-48673860
CONAN: Copy Number AnalysisLIG1 
Mutations and Diseases : HGMDLIG1
OMIM126391   
MedgenLIG1
NextProtP18858 [Medical]
GENETestsLIG1
Disease Genetic AssociationLIG1
Huge Navigator LIG1 [HugePedia]  LIG1 [HugeCancerGEM]
snp3D : Map Gene to Disease3978
DGIdb (Drug Gene Interaction db)LIG1
General knowledge
Homologs : HomoloGeneLIG1
Homology/Alignments : Family Browser (UCSC)LIG1
Phylogenetic Trees/Animal Genes : TreeFamLIG1
Chemical/Protein Interactions : CTD3978
Chemical/Pharm GKB GenePA30372
Clinical trialLIG1
Cancer Resource (Charite)ENSG00000105486
Other databases
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
CoreMineLIG1
GoPubMedLIG1
iHOPLIG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:41:15 CEST 2015

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