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LIG1 (ligase I, DNA, ATP-dependent)

Identity

Other namesMGC117397
MGC130025
HGNC (Hugo) LIG1
Location 19q13.33
Location_base_pair Starts at 48618706 and ends at 48673583 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LIG1   6598
Entrez_Gene (NCBI)LIG1  3978  ligase I, DNA, ATP-dependent
Cards
GeneCards (Weizmann)LIG1
Ensembl (Hinxton)ENSG00000105486 [Gene_View]  LIG1 [Vega]
AceView (NCBI)LIG1
Genatlas (Paris)LIG1
euGene (Indiana)3978
SOURCE (Stanford)NM_000234
Gene Expression (Array Express) ENSG00000105486
Genomic and cartography
GoldenPath (UCSC)LIG1  -  19q13.33   chr19:48618706-48673583 -  19q13.33   [Description]    (hg19-Feb_2009)
EnsemblLIG1 - 19q13.33 [CytoView]
Mapping of homologs : NCBILIG1 [Mapview]
OMIM126391   
Gene and transcription
Gene : Genbank (Entrez)AB208791 AK225863 AK297296 AK300370 AK300607
Reference sequence (RefSeq transcript) :SRSNM_000234
Reference transcript : EntrezNM_000234
RefSeq genomic : SRSAC_000062 AC_000151 NC_000019 NG_007395 NT_011109 NW_001838497 NW_927240
RefSeq genomic : EntrezAC_000062 AC_000151 NC_000019 NG_007395 NT_011109 NW_001838497 NW_927240
Consensus coding sequences : CCDS NCBILIG1
Cluster EST : UnigeneHs.1770 [ SRS ] Hs.1770 [ NCBI ]
Alternative Splicing : Fast-db (Paris)13852
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP18858 (SRS) P18858 (Expasy) P18858 (Uniprot)
With graphics : InterProP18858
Splice isoforms : VarSplice FASTAP18858(VarSplice FASTA)
Domaine pattern : Prosite (SRS)DNA_LIGASE_A1 (PS00697)    DNA_LIGASE_A2 (PS00333)    DNA_LIGASE_A3 (PS50160)   
Domain pattern : Prosite (Expaxy)DNA_LIGASE_A1 (PS00697)    DNA_LIGASE_A2 (PS00333)    DNA_LIGASE_A3 (PS50160)   
Domains : Interpro (SRS)DNA_ligase    DNA_ligase_A_C    DNA_ligase_A_M    DNA_ligase_A_N    DNA_ligase_CS    NA-bd_OB-fold   
Domains : Interpro (EBI)DNA_ligase    DNA_ligase_A_C    DNA_ligase_A_M    DNA_ligase_A_N    DNA_ligase_CS    NA-bd_OB-fold   
Related proteins : CluSTrP18858
Domain families : Pfam SRSDNA_ligase_A_C (PF04679)    DNA_ligase_A_M (PF01068)    DNA_ligase_A_N (PF04675)   
Domain families : Pfam SangerDNA_ligase_A_C (PF04679)    DNA_ligase_A_M (PF01068)    DNA_ligase_A_N (PF04675)   
Domain families : Pfam NCBIpfam04679    pfam01068    pfam04675   
Blocks (Seattle)P18858
Crystal structure of protein : PDB SRS1X9N   
Crystal structure of protein : PDBSum1X9N   
Crystal structure of protein : IMB1X9N   
Crystal structure of protein : PDB RSDB1X9N   
Human Protein AtlasENSG00000105486
HPRD00534
Protein Interaction databases
DIP (DOE-UCLA)P18858
IntAct (EBI)P18858
FunCoupENSG00000105486
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBILIG1
SNP : GeneSNP UtahLIG1
SNP : HGBaseLIG1
Genetic variants : HAPMAPLIG1
Somatic Mutations in Cancer : COSMICLIG1 
Mutations and Diseases : HGMDLIG1
Hereditary diseases : OMIM126391   
Hereditary diseases : GENETests126391   
Diseases : Genetic AssociationLIG1
General knowledge
Homologs : HomoloGeneLIG1
Homology/Alignments : Family Browser UCSCLIG1
Phylogenetic Trees/Animal Genes : TreeFamLIG1
Catalytic activity : Enzyme6.5.1.1 [ Enzyme-Expasy ]   6.5.1.1 [ Enzyme-SRS ]   6.5.1.1 [ IntEnz-EBI ]   6.5.1.1 [ BRENDA ]   6.5.1.1 [ KEGG ]   
Chemical/Protein Interactions : CTD3978
Keywords Ontology : AmiGOnucleotide binding  DNA binding  DNA ligase activity  DNA ligase activity  DNA ligase (ATP) activity  ATP binding  nucleus  nucleoplasm  DNA metabolic process  DNA replication  DNA repair  nucleotide-excision repair, DNA gap filling  DNA recombination  cell cycle  anatomical structure morphogenesis  ligase activity  V(D)J recombination  metal ion binding  cell division  
Keywords Ontology : EGO-EBInucleotide binding  DNA binding  DNA ligase activity  DNA ligase activity  DNA ligase (ATP) activity  ATP binding  nucleus  nucleoplasm  DNA metabolic process  DNA replication  DNA repair  nucleotide-excision repair, DNA gap filling  DNA recombination  cell cycle  anatomical structure morphogenesis  ligase activity  V(D)J recombination  metal ion binding  cell division  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesLIG1 Related clones (RZPD - Berlin)
Literature
PubMed69 Pubmed reference(s) in Entrez
PubGeneLIG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated07-2010Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 31 19:56:35 CEST 2010
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