| Nomenclature |
|---|
| HGNC (Hugo) | LIG3 6600 |
| Cards |
|---|
| Entrez_Gene (NCBI) | LIG3 DNA ligase 3 |
| Aliases | LIG2; LIG3alpha |
| GeneCards (Weizmann) | LIG3 |
| Ensembl hg19 (Hinxton) | ENSG00000005156 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000005156 [Gene_View] ENSG00000005156 [Sequence] chr17:34980512-35009743 [Contig_View] LIG3 [Vega] |
| ICGC DataPortal | ENSG00000005156 |
| TCGA cBioPortal | LIG3 |
| AceView (NCBI) | LIG3 |
| Genatlas (Paris) | LIG3 |
| SOURCE (Princeton) | LIG3 |
| Genetics Home Reference (NIH) | LIG3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | LIG3 - chr17:34980512-35009743 + 17q12 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | LIG3 - 17q12 [Description] (hg19-Feb_2009) |
| GoldenPath | LIG3 - 17q12 [CytoView hg19] LIG3 - 17q12 [CytoView hg38] |
| ImmunoBase | ENSG00000005156 |
| genome Data Viewer NCBI | LIG3 [Mapview hg19] |
| OMIM | 600940 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA872458 AK091492 AK125853 AK300363 AK308407 |
| RefSeq transcript (Entrez) | NM_002311 NM_013975 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | LIG3 |
| Alternative Splicing Gallery | ENSG00000005156 |
| Gene Expression | LIG3 [ NCBI-GEO ] LIG3 [ EBI - ARRAY_EXPRESS ]
LIG3 [ SEEK ] LIG3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | LIG3 [ Firebrowse - Broad ] |
| Genevisible | Expression of LIG3 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3980 |
| GTEX Portal (Tissue expression) | LIG3 |
| Human Protein Atlas | ENSG00000005156-LIG3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P49916 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P49916 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P49916 |
| Splice isoforms : SwissVar | P49916 |
| PhosPhoSitePlus | P49916 |
| Domaine pattern : Prosite (Expaxy) | BRCT (PS50172) DNA_LIGASE_A1 (PS00697) DNA_LIGASE_A2 (PS00333) DNA_LIGASE_A3 (PS50160) PARP_ZN_FINGER_1 (PS00347) PARP_ZN_FINGER_2 (PS50064) |
| Domains : Interpro (EBI) | BRCT_dom BRCT_dom_sf DNA_ligase_ATP-dep DNA_ligase_ATP-dep_C DNA_ligase_ATP-dep_cent DNA_ligase_ATP-dep_CS DNA_ligase_ATP-dep_N DNA_ligase_N_sf LIG3_BRCT NA-bd_OB-fold Znf_PARP Znf_PARP_sf |
| Domain families : Pfam (Sanger) | DNA_ligase_A_C (PF04679) DNA_ligase_A_M (PF01068) DNA_ligase_A_N (PF04675) LIG3_BRCT (PF16759) zf-PARP (PF00645) |
| Domain families : Pfam (NCBI) | pfam04679 pfam01068 pfam04675 pfam16759 pfam00645 |
| Domain families : Smart (EMBL) | BRCT (SM00292) zf-PARP (SM01336) |
| Conserved Domain (NCBI) | LIG3 |
| Blocks (Seattle) | LIG3 |
| PDB (RSDB) | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| PDB Europe | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| PDB (PDBSum) | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| PDB (IMB) | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| Structural Biology KnowledgeBase | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| SCOP (Structural Classification of Proteins) | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| CATH (Classification of proteins structures) | 1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG |
| Superfamily | P49916 |
| Human Protein Atlas [tissue] | ENSG00000005156-LIG3 [tissue] |
| Peptide Atlas | P49916 |
| HPRD | 02966 |
| IPI | IPI00029081 IPI00000156 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P49916 |
| IntAct (EBI) | P49916 |
| BioGRID | LIG3 |
| STRING (EMBL) | LIG3 |
| ZODIAC | LIG3 |
| Ontologies - Pathways |
|---|
| QuickGO | P49916 |
| Ontology : AmiGO | double-strand break repair via homologous recombination DNA binding DNA ligase activity DNA ligase activity DNA ligase (ATP) activity protein binding ATP binding nucleoplasm nucleoplasm cytoplasm DNA ligation lagging strand elongation DNA repair transcription-coupled nucleotide-excision repair base-excision repair, DNA ligation base-excision repair, DNA ligation base-excision repair, DNA ligation nucleotide-excision repair, DNA gap filling double-strand break repair cell cycle zinc ion binding V(D)J recombination mitochondrial DNA repair DNA ligation involved in DNA repair cell division DNA ligase III-XRCC1 complex DNA biosynthetic process negative regulation of mitochondrial DNA replication double-strand break repair via alternative nonhomologous end joining |
| Ontology : EGO-EBI | double-strand break repair via homologous recombination DNA binding DNA ligase activity DNA ligase activity DNA ligase (ATP) activity protein binding ATP binding nucleoplasm nucleoplasm cytoplasm DNA ligation lagging strand elongation DNA repair transcription-coupled nucleotide-excision repair base-excision repair, DNA ligation base-excision repair, DNA ligation base-excision repair, DNA ligation nucleotide-excision repair, DNA gap filling double-strand break repair cell cycle zinc ion binding V(D)J recombination mitochondrial DNA repair DNA ligation involved in DNA repair cell division DNA ligase III-XRCC1 complex DNA biosynthetic process negative regulation of mitochondrial DNA replication double-strand break repair via alternative nonhomologous end joining |
| Pathways : KEGG | Base excision repair |
| NDEx Network | LIG3 |
| Atlas of Cancer Signalling Network | LIG3 |
| Wikipedia pathways | LIG3 |
| Orthology - Evolution |
|---|
| OrthoDB | 3980 |
| GeneTree (enSembl) | ENSG00000005156 |
| Phylogenetic Trees/Animal Genes : TreeFam | LIG3 |
| HOGENOM | P49916 |
| Homologs : HomoloGene | LIG3 |
| Homology/Alignments : Family Browser (UCSC) | LIG3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | LIG3/HAP1 [17q12/17q21.2] |
| Fusion : Mitelman | LIG3/KXD1 [17q12/19p13.11] |
| Fusion : Mitelman | LIG3/ZFAT [17q12/8q24.22] |
| Fusion Portal | LIG3 17q12 C19orf50 BRCA |
| Fusion Portal | LIG3 17q12 HAP1 17q21.2 BRCA |
| Fusion Portal | LIG3 17q12 ZFAT 8q24.22 BRCA |
| Fusion : Quiver | LIG3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | LIG3 [hg38] |
| dbVar | LIG3 |
| ClinVar | LIG3 |
| Monarch | LIG3 |
| 1000_Genomes | LIG3 |
| Exome Variant Server | LIG3 |
| GNOMAD Browser | ENSG00000005156 |
| Varsome Browser | LIG3 |
| Genomic Variants (DGV) | LIG3 [DGVbeta] |
| DECIPHER | LIG3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | LIG3 |
| Mutations |
|---|
| ICGC Data Portal | LIG3 |
| TCGA Data Portal | LIG3 |
| Broad Tumor Portal | LIG3 |
| OASIS Portal | LIG3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | LIG3 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | LIG3 |
| Mutations and Diseases : HGMD | LIG3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search LIG3 |
| DgiDB (Drug Gene Interaction Database) | LIG3 |
| DoCM (Curated mutations) | LIG3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | LIG3 (select a term) |
| intoGen | LIG3 |
| Cancer3D | LIG3(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600940 |
| Orphanet | |
| DisGeNET | LIG3 |
| Medgen | LIG3 |
| Genetic Testing Registry | LIG3
|
| NextProt | P49916 [Medical] |
| GENETests | LIG3 |
| Target Validation | LIG3 |
| Huge Navigator |
LIG3 [HugePedia] |
| ClinGen | LIG3 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | LIG3 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA30374 |
| Pharos | P49916 |
| Clinical trial | LIG3 |
| Miscellaneous |
|---|
| canSAR (ICR) | LIG3 (select the gene name) |
| Harmonizome | LIG3 |
| DataMed Index | LIG3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 141 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | LIG3 |
