LILRA2 (leukocyte immunoglobulin like receptor A2)

2018-12-01  

Identity

HGNC
LILRA2
LOCATION
19q13.42
LOCUSID
11027
ALIAS
CD85H,ILT1,LIR-7,LIR7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11027
MIM: 604812
HGNC: 6603
Ensembl: ENSG00000239998

Variants:

dbSNP: 11027
ClinVar: 11027
TCGA: ENSG00000239998
COSMIC: LILRA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239998ENST00000251376Q8N149
ENSG00000239998ENST00000251377Q8N149
ENSG00000239998ENST00000391737A8MZH0
ENSG00000239998ENST00000391738Q8N149
ENSG00000239998ENST00000439534E9PDF4
ENSG00000239998ENST00000472992A0A087WT41
ENSG00000239998ENST00000629481A0A0D9SFC7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
125295062003Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.35
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
180563552007LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells.22
152428762004Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.20
179983012008Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.13
224794042012LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes.13
192300612009Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes.12
182730332008Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis.7
182730332008Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis.7

Citation

Dessen P

LILRA2 (leukocyte immunoglobulin like receptor A2)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57770/lilra2