LILRA3 (leukocyte immunoglobulin like receptor A3)

2014-08-01  

Identity

HGNC
LILRA3
LOCATION
19q13.4
LOCUSID
11026
ALIAS
CD85E,HM31,HM43,ILT-6,ILT6,LIR-4,LIR4

Other Information

Locus ID:

NCBI: 11026
MIM: 604818
HGNC: 6604

Variants:

dbSNP: 11026
ClinVar: 11026
COSMIC: LILRA3

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
212704082011HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.51
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
215594242011LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.19
184395452008Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians.17
158156902005Association of multiple sclerosis with ILT6 deficiency.16
205952772010Soluble LILRA3, a potential natural antiinflammatory protein, is increased in patients with rheumatoid arthritis and is tightly regulated by interleukin 10, tumor necrosis factor-alpha, and interferon-gamma.14
197900592009Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome.13
194212242009Multiple sclerosis associates with LILRA3 deletion in Spanish patients.12
194212242009Multiple sclerosis associates with LILRA3 deletion in Spanish patients.12
249066392015Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjögren's syndrome.11

Citation

Dessen P

LILRA3 (leukocyte immunoglobulin like receptor A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54845/lilra3