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LILRB1 (leukocyte immunoglobulin like receptor B1)

Identity

Alias_namesleukocyte immunoglobulin-like receptor
Alias_symbol (synonym)LIR-1
ILT2
MIR-7
CD85
LIR1
CD85j
PIRB
PIR-B
Other aliasCD85J
ILT-2
MIR7
HGNC (Hugo) LILRB1
LocusID (NCBI) 10859
Atlas_Id 51630
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54630517 and ends at 54637530 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LILRB1 (19q13.42) / LYZ (12q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LILRB1   6605
Cards
Entrez_Gene (NCBI)LILRB1  10859  leukocyte immunoglobulin like receptor B1
AliasesCD85J; ILT-2; ILT2; LIR-1; 
LIR1; MIR-7; MIR7; PIR-B; PIRB
GeneCards (Weizmann)LILRB1
Ensembl hg19 (Hinxton)ENSG00000104972 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104972 [Gene_View]  chr19:54630517-54637530 [Contig_View]  LILRB1 [Vega]
ICGC DataPortalENSG00000104972
TCGA cBioPortalLILRB1
AceView (NCBI)LILRB1
Genatlas (Paris)LILRB1
WikiGenes10859
SOURCE (Princeton)LILRB1
Genetics Home Reference (NIH)LILRB1
Genomic and cartography
GoldenPath hg38 (UCSC)LILRB1  -     chr19:54630517-54637530 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LILRB1  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblLILRB1 - 19q13.42 [CytoView hg19]  LILRB1 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBILILRB1 [Mapview hg19]  LILRB1 [Mapview hg38]
OMIM604811   
Gene and transcription
Genbank (Entrez)AF009005 AF009006 AF009007 AF009220 AF009221
RefSeq transcript (Entrez)NM_001081637 NM_001081638 NM_001081639 NM_001278398 NM_001278399 NM_006669
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_187693 NW_003571054 NW_003571060
Consensus coding sequences : CCDS (NCBI)LILRB1
Cluster EST : UnigeneHs.667388 [ NCBI ]
CGAP (NCI)Hs.667388
Alternative Splicing GalleryENSG00000104972
Gene ExpressionLILRB1 [ NCBI-GEO ]   LILRB1 [ EBI - ARRAY_EXPRESS ]   LILRB1 [ SEEK ]   LILRB1 [ MEM ]
Gene Expression Viewer (FireBrowse)LILRB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10859
GTEX Portal (Tissue expression)LILRB1
Human Protein AtlasENSG00000104972-LILRB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NHL6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NHL6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NHL6
Splice isoforms : SwissVarQ8NHL6
PhosPhoSitePlusQ8NHL6
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2    Immunoglobulin   
Domain families : Pfam (Sanger)ig (PF00047)    Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam00047    pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)LILRB1
DMDM Disease mutations10859
Blocks (Seattle)LILRB1
PDB (SRS)1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
PDB (PDBSum)1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
PDB (IMB)1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
PDB (RSDB)1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
Structural Biology KnowledgeBase1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
SCOP (Structural Classification of Proteins)1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
CATH (Classification of proteins structures)1G0X    1P7Q    1UFU    1UGN    1VDG    3D2U    4LL9    4NO0   
SuperfamilyQ8NHL6
Human Protein Atlas [tissue]ENSG00000104972-LILRB1 [tissue]
Peptide AtlasQ8NHL6
HPRD07273
IPIIPI00643313   IPI00853070   IPI00020967   IPI00658078   IPI00853520   IPI00657948   IPI00894149   
Protein Interaction databases
DIP (DOE-UCLA)Q8NHL6
IntAct (EBI)Q8NHL6
FunCoupENSG00000104972
BioGRIDLILRB1
STRING (EMBL)LILRB1
ZODIACLILRB1
Ontologies - Pathways
QuickGOQ8NHL6
Ontology : AmiGOnegative regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  adaptive immune response  T cell proliferation involved in immune response  negative regulation of cytokine secretion involved in immune response  immune response-inhibiting cell surface receptor signaling pathway  Fc receptor mediated inhibitory signaling pathway  extracellular region  cytoplasm  plasma membrane  signal transduction  protein phosphatase 1 binding  response to virus  external side of plasma membrane  positive regulation of gene expression  negative regulation of serotonin secretion  integral component of membrane  HLA-A specific inhibitory MHC class I receptor activity  HLA-B specific inhibitory MHC class I receptor activity  receptor internalization  MHC class I receptor activity  interferon-gamma production  negative regulation of interferon-gamma production  negative regulation of mononuclear cell proliferation  negative regulation of interferon-beta secretion  negative regulation of T cell proliferation  SH2 domain binding  MHC class I protein binding  MHC class I protein binding  MHC class I protein binding  negative regulation of tumor necrosis factor biosynthetic process  protein homodimerization activity  positive regulation of apoptotic process  negative regulation of interferon-gamma biosynthetic process  negative regulation of cell cycle  negative regulation of endocytosis  positive regulation of cytolysis  positive regulation of cytolysis  positive regulation of transcription from RNA polymerase II promoter  negative regulation of natural killer cell mediated cytotoxicity  negative regulation of alpha-beta T cell activation  regulation of immune response  defense response to virus  negative regulation of calcium ion transport  cellular response to lipopolysaccharide  interferon-gamma secretion  dendritic cell differentiation  negative regulation of dendritic cell apoptotic process  negative regulation of interleukin-10 secretion  negative regulation of interleukin-12 secretion  negative regulation of CD8-positive, alpha-beta T cell activation  negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  positive regulation of gamma-delta T cell activation involved in immune response  negative regulation of dendritic cell differentiation  negative regulation of transforming growth factor-beta secretion  negative regulation of osteoclast development  
Ontology : EGO-EBInegative regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  adaptive immune response  T cell proliferation involved in immune response  negative regulation of cytokine secretion involved in immune response  immune response-inhibiting cell surface receptor signaling pathway  Fc receptor mediated inhibitory signaling pathway  extracellular region  cytoplasm  plasma membrane  signal transduction  protein phosphatase 1 binding  response to virus  external side of plasma membrane  positive regulation of gene expression  negative regulation of serotonin secretion  integral component of membrane  HLA-A specific inhibitory MHC class I receptor activity  HLA-B specific inhibitory MHC class I receptor activity  receptor internalization  MHC class I receptor activity  interferon-gamma production  negative regulation of interferon-gamma production  negative regulation of mononuclear cell proliferation  negative regulation of interferon-beta secretion  negative regulation of T cell proliferation  SH2 domain binding  MHC class I protein binding  MHC class I protein binding  MHC class I protein binding  negative regulation of tumor necrosis factor biosynthetic process  protein homodimerization activity  positive regulation of apoptotic process  negative regulation of interferon-gamma biosynthetic process  negative regulation of cell cycle  negative regulation of endocytosis  positive regulation of cytolysis  positive regulation of cytolysis  positive regulation of transcription from RNA polymerase II promoter  negative regulation of natural killer cell mediated cytotoxicity  negative regulation of alpha-beta T cell activation  regulation of immune response  defense response to virus  negative regulation of calcium ion transport  cellular response to lipopolysaccharide  interferon-gamma secretion  dendritic cell differentiation  negative regulation of dendritic cell apoptotic process  negative regulation of interleukin-10 secretion  negative regulation of interleukin-12 secretion  negative regulation of CD8-positive, alpha-beta T cell activation  negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  positive regulation of gamma-delta T cell activation involved in immune response  negative regulation of dendritic cell differentiation  negative regulation of transforming growth factor-beta secretion  negative regulation of osteoclast development  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkLILRB1
Atlas of Cancer Signalling NetworkLILRB1
Wikipedia pathwaysLILRB1
Orthology - Evolution
OrthoDB10859
GeneTree (enSembl)ENSG00000104972
Phylogenetic Trees/Animal Genes : TreeFamLILRB1
HOVERGENQ8NHL6
HOGENOMQ8NHL6
Homologs : HomoloGeneLILRB1
Homology/Alignments : Family Browser (UCSC)LILRB1
Gene fusions - Rearrangements
Tumor Fusion PortalLILRB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLILRB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LILRB1
dbVarLILRB1
ClinVarLILRB1
1000_GenomesLILRB1 
Exome Variant ServerLILRB1
ExAC (Exome Aggregation Consortium)ENSG00000104972
GNOMAD BrowserENSG00000104972
Genetic variants : HAPMAP10859
Genomic Variants (DGV)LILRB1 [DGVbeta]
DECIPHERLILRB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLILRB1 
Mutations
ICGC Data PortalLILRB1 
TCGA Data PortalLILRB1 
Broad Tumor PortalLILRB1
OASIS PortalLILRB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLILRB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLILRB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LILRB1
DgiDB (Drug Gene Interaction Database)LILRB1
DoCM (Curated mutations)LILRB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LILRB1 (select a term)
intoGenLILRB1
Cancer3DLILRB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604811   
Orphanet
DisGeNETLILRB1
MedgenLILRB1
Genetic Testing Registry LILRB1
NextProtQ8NHL6 [Medical]
TSGene10859
GENETestsLILRB1
Target ValidationLILRB1
Huge Navigator LILRB1 [HugePedia]
snp3D : Map Gene to Disease10859
BioCentury BCIQLILRB1
ClinGenLILRB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10859
Chemical/Pharm GKB GenePA30379
Clinical trialLILRB1
Miscellaneous
canSAR (ICR)LILRB1 (select the gene name)
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLILRB1
EVEXLILRB1
GoPubMedLILRB1
iHOPLILRB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:19:53 CET 2017

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