LILRB2 (leukocyte immunoglobulin like receptor B2)

2012-08-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD85D,ILT-4,ILT4,LIR-2,LIR2,MIR-10,MIR10

Other Information

Locus ID:

NCBI: 10288
MIM: 604815
HGNC: 6606
Ensembl: ENSG00000131042

Variants:

dbSNP: 10288
ClinVar: 10288
TCGA: ENSG00000131042
COSMIC: LILRB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131042ENST00000314446Q8N423
ENSG00000131042ENST00000314446A2IXV5
ENSG00000131042ENST00000391746Q8N423
ENSG00000131042ENST00000391748Q8N423
ENSG00000131042ENST00000391748A2IXV5
ENSG00000131042ENST00000391749Q8N423
ENSG00000131042ENST00000434421Q8N423
ENSG00000131042ENST00000455108H7C0C3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
204481102010Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.172
240523082013Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.118
128535762003Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.115
226603302012Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.83
170567152006Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).76
156709762005HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.62
185508252008Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.53
212704082011HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.51
195356442009Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.45
174202632007Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation.30

Citation

Dessen P

LILRB2 (leukocyte immunoglobulin like receptor B2)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52791/lilrb2