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LILRB2 (leukocyte immunoglobulin like receptor B2)

Identity

Alias_namesleukocyte immunoglobulin-like receptor
Alias_symbol (synonym)LIR-2
ILT4
MIR-10
LIR2
CD85d
MIR10
Other aliasCD85D
ILT-4
HGNC (Hugo) LILRB2
LocusID (NCBI) 10288
Atlas_Id 52791
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54273821 and ends at 54281178 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LILRB2   6606
Cards
Entrez_Gene (NCBI)LILRB2  10288  leukocyte immunoglobulin like receptor B2
AliasesCD85D; ILT-4; ILT4; LIR-2; 
LIR2; MIR-10; MIR10
GeneCards (Weizmann)LILRB2
Ensembl hg19 (Hinxton)ENSG00000131042 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131042 [Gene_View]  chr19:54273821-54281178 [Contig_View]  LILRB2 [Vega]
ICGC DataPortalENSG00000131042
TCGA cBioPortalLILRB2
AceView (NCBI)LILRB2
Genatlas (Paris)LILRB2
WikiGenes10288
SOURCE (Princeton)LILRB2
Genetics Home Reference (NIH)LILRB2
Genomic and cartography
GoldenPath hg38 (UCSC)LILRB2  -     chr19:54273821-54281178 -  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LILRB2  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblLILRB2 - 19q13.42 [CytoView hg19]  LILRB2 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBILILRB2 [Mapview hg19]  LILRB2 [Mapview hg38]
OMIM604815   
Gene and transcription
Genbank (Entrez)AF000574 AF004231 AF011565 AF011566 AF025528
RefSeq transcript (Entrez)NM_001080978 NM_001278403 NM_001278404 NM_001278405 NM_001278406 NM_005874
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_187693 NW_003571054 NW_003571060 NW_003571061
Consensus coding sequences : CCDS (NCBI)LILRB2
Cluster EST : UnigeneHs.655652 [ NCBI ]
CGAP (NCI)Hs.655652
Alternative Splicing GalleryENSG00000131042
Gene ExpressionLILRB2 [ NCBI-GEO ]   LILRB2 [ EBI - ARRAY_EXPRESS ]   LILRB2 [ SEEK ]   LILRB2 [ MEM ]
Gene Expression Viewer (FireBrowse)LILRB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10288
GTEX Portal (Tissue expression)LILRB2
Human Protein AtlasENSG00000131042-LILRB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N423   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N423  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N423
Splice isoforms : SwissVarQ8N423
PhosPhoSitePlusQ8N423
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)LILRB2
DMDM Disease mutations10288
Blocks (Seattle)LILRB2
PDB (SRS)2DYP    2GW5    4LLA   
PDB (PDBSum)2DYP    2GW5    4LLA   
PDB (IMB)2DYP    2GW5    4LLA   
PDB (RSDB)2DYP    2GW5    4LLA   
Structural Biology KnowledgeBase2DYP    2GW5    4LLA   
SCOP (Structural Classification of Proteins)2DYP    2GW5    4LLA   
CATH (Classification of proteins structures)2DYP    2GW5    4LLA   
SuperfamilyQ8N423
Human Protein Atlas [tissue]ENSG00000131042-LILRB2 [tissue]
Peptide AtlasQ8N423
HPRD11994
IPIIPI00893900   IPI00376762   IPI00917991   IPI00794705   IPI00829744   IPI00971128   IPI01011452   IPI00894373   IPI00916901   
Protein Interaction databases
DIP (DOE-UCLA)Q8N423
IntAct (EBI)Q8N423
FunCoupENSG00000131042
BioGRIDLILRB2
STRING (EMBL)LILRB2
ZODIACLILRB2
Ontologies - Pathways
QuickGOQ8N423
Ontology : AmiGOadaptive immune response  negative regulation of antigen processing and presentation  positive regulation of tolerance induction  positive regulation of T cell tolerance induction  immune response-inhibiting cell surface receptor signaling pathway  immune response-inhibiting cell surface receptor signaling pathway  Fc receptor mediated inhibitory signaling pathway  receptor activity  protein binding  extracellular space  cytoplasm  plasma membrane  integral component of plasma membrane  immune response  cellular defense response  signal transduction  signal transduction  cell surface receptor signaling pathway  cell-cell signaling  protein phosphatase 1 binding  cell surface  membrane  MHC class Ib protein binding  inhibitory MHC class I receptor activity  inhibitory MHC class I receptor activity  positive regulation of interleukin-6 production  heterotypic cell-cell adhesion  positive regulation of T cell proliferation  negative regulation of T cell proliferation  negative regulation of T cell proliferation  MHC class I protein binding  MHC class I protein binding  neutrophil degranulation  positive regulation of regulatory T cell differentiation  regulation of immune response  negative regulation of immune response  cell adhesion molecule binding  negative regulation of calcium ion transport  tertiary granule membrane  cellular response to lipopolysaccharide  ficolin-1-rich granule membrane  regulation of dendritic cell differentiation  
Ontology : EGO-EBIadaptive immune response  negative regulation of antigen processing and presentation  positive regulation of tolerance induction  positive regulation of T cell tolerance induction  immune response-inhibiting cell surface receptor signaling pathway  immune response-inhibiting cell surface receptor signaling pathway  Fc receptor mediated inhibitory signaling pathway  receptor activity  protein binding  extracellular space  cytoplasm  plasma membrane  integral component of plasma membrane  immune response  cellular defense response  signal transduction  signal transduction  cell surface receptor signaling pathway  cell-cell signaling  protein phosphatase 1 binding  cell surface  membrane  MHC class Ib protein binding  inhibitory MHC class I receptor activity  inhibitory MHC class I receptor activity  positive regulation of interleukin-6 production  heterotypic cell-cell adhesion  positive regulation of T cell proliferation  negative regulation of T cell proliferation  negative regulation of T cell proliferation  MHC class I protein binding  MHC class I protein binding  neutrophil degranulation  positive regulation of regulatory T cell differentiation  regulation of immune response  negative regulation of immune response  cell adhesion molecule binding  negative regulation of calcium ion transport  tertiary granule membrane  cellular response to lipopolysaccharide  ficolin-1-rich granule membrane  regulation of dendritic cell differentiation  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkLILRB2
Atlas of Cancer Signalling NetworkLILRB2
Wikipedia pathwaysLILRB2
Orthology - Evolution
OrthoDB10288
GeneTree (enSembl)ENSG00000131042
Phylogenetic Trees/Animal Genes : TreeFamLILRB2
HOVERGENQ8N423
HOGENOMQ8N423
Homologs : HomoloGeneLILRB2
Homology/Alignments : Family Browser (UCSC)LILRB2
Gene fusions - Rearrangements
Tumor Fusion PortalLILRB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLILRB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LILRB2
dbVarLILRB2
ClinVarLILRB2
1000_GenomesLILRB2 
Exome Variant ServerLILRB2
ExAC (Exome Aggregation Consortium)ENSG00000131042
GNOMAD BrowserENSG00000131042
Genetic variants : HAPMAP10288
Genomic Variants (DGV)LILRB2 [DGVbeta]
DECIPHERLILRB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLILRB2 
Mutations
ICGC Data PortalLILRB2 
TCGA Data PortalLILRB2 
Broad Tumor PortalLILRB2
OASIS PortalLILRB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLILRB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLILRB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LILRB2
DgiDB (Drug Gene Interaction Database)LILRB2
DoCM (Curated mutations)LILRB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LILRB2 (select a term)
intoGenLILRB2
Cancer3DLILRB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604815   
Orphanet
DisGeNETLILRB2
MedgenLILRB2
Genetic Testing Registry LILRB2
NextProtQ8N423 [Medical]
TSGene10288
GENETestsLILRB2
Target ValidationLILRB2
Huge Navigator LILRB2 [HugePedia]
snp3D : Map Gene to Disease10288
BioCentury BCIQLILRB2
ClinGenLILRB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10288
Chemical/Pharm GKB GenePA30380
Clinical trialLILRB2
Miscellaneous
canSAR (ICR)LILRB2 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLILRB2
EVEXLILRB2
GoPubMedLILRB2
iHOPLILRB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:19:53 CET 2017

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