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LIMK2 (LIM domain kinase 2)

Identity

Alias (NCBI)-
HGNC (Hugo) LIMK2
LocusID (NCBI) 3985
Atlas_Id 41160
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31248384 and ends at 31280080 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LIMK2 (22q12.2)::ATG2A (11q13.1)LIMK2 (22q12.2)::ATXN10 (22q13.31)LIMK2 (22q12.2)::CDC45 (22q11.21)
LIMK2 (22q12.2)::OSBP2 (22q12.2)LIMK2 (22q12.2)::RUFY1 (5q35.3)SFI1 (22q12.2)::LIMK2 (22q12.2)
LIMK2 22q12.2::ATXN10 22q13.31LIMK2 22q12.2::CDC45 22q11.21LIMK2 22q12.2::OSBP2 22q12.2
LIMK2 22q12.2::RUFY1 5q35.3SFI1 22q12.2::LIMK2 22q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LIMK2   6614
Cards
Entrez_Gene (NCBI)LIMK2    LIM domain kinase 2
Aliases
GeneCards (Weizmann)LIMK2
Ensembl hg19 (Hinxton)ENSG00000182541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182541 [Gene_View]  ENSG00000182541 [Sequence]  chr22:31248384-31280080 [Contig_View]  LIMK2 [Vega]
ICGC DataPortalENSG00000182541
TCGA cBioPortalLIMK2
AceView (NCBI)LIMK2
Genatlas (Paris)LIMK2
SOURCE (Princeton)LIMK2
Genetics Home Reference (NIH)LIMK2
Genomic and cartography
GoldenPath hg38 (UCSC)LIMK2  -     chr22:31248384-31280080 +  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LIMK2  -     22q12.2   [Description]    (hg19-Feb_2009)
GoldenPathLIMK2 - 22q12.2 [CytoView hg19]  LIMK2 - 22q12.2 [CytoView hg38]
ImmunoBaseENSG00000182541
Genome Data Viewer NCBILIMK2 [Mapview hg19]  
OMIM601988   
Gene and transcription
Genbank (Entrez)AB451269 AB451396 AK092838 AK093554 AK291640
RefSeq transcript (Entrez)NM_001031801 NM_005569 NM_016733
Consensus coding sequences : CCDS (NCBI)LIMK2
Gene ExpressionLIMK2 [ NCBI-GEO ]   LIMK2 [ EBI - ARRAY_EXPRESS ]   LIMK2 [ SEEK ]   LIMK2 [ MEM ]
Gene Expression Viewer (FireBrowse)LIMK2 [ Firebrowse - Broad ]
GenevisibleExpression of LIMK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3985
GTEX Portal (Tissue expression)LIMK2
Human Protein AtlasENSG00000182541-LIMK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53671   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53671  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53671
PhosPhoSitePlusP53671
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)    PDZ (PS50106)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PDZ    PDZ_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)    PDZ (PF00595)    PK_Tyr_Ser-Thr (PF07714)   
Domain families : Pfam (NCBI)pfam00412    pfam00595    pfam07714   
Domain families : Smart (EMBL)LIM (SM00132)  PDZ (SM00228)  
Conserved Domain (NCBI)LIMK2
PDB (RSDB)1X6A    4TPT    5NXD   
PDB Europe1X6A    4TPT    5NXD   
PDB (PDBSum)1X6A    4TPT    5NXD   
PDB (IMB)1X6A    4TPT    5NXD   
Structural Biology KnowledgeBase1X6A    4TPT    5NXD   
SCOP (Structural Classification of Proteins)1X6A    4TPT    5NXD   
CATH (Classification of proteins structures)1X6A    4TPT    5NXD   
SuperfamilyP53671
AlphaFold pdb e-kbP53671   
Human Protein Atlas [tissue]ENSG00000182541-LIMK2 [tissue]
HPRD03585
Protein Interaction databases
DIP (DOE-UCLA)P53671
IntAct (EBI)P53671
BioGRIDLIMK2
STRING (EMBL)LIMK2
ZODIACLIMK2
Ontologies - Pathways
QuickGOP53671
Ontology : AmiGOpositive regulation of protein phosphorylation  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cis-Golgi network  centrosome  protein phosphorylation  spermatogenesis  phosphorylation  actin cytoskeleton organization  astral microtubule organization  metal ion binding  perinuclear region of cytoplasm  establishment of vesicle localization  head development  cornea development in camera-type eye  mitotic spindle  protein serine kinase activity  positive regulation of protein localization to nucleus  negative regulation of cilium assembly  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cis-Golgi network  centrosome  protein phosphorylation  spermatogenesis  phosphorylation  actin cytoskeleton organization  astral microtubule organization  metal ion binding  perinuclear region of cytoplasm  establishment of vesicle localization  head development  cornea development in camera-type eye  mitotic spindle  protein serine kinase activity  positive regulation of protein localization to nucleus  negative regulation of cilium assembly  
Pathways : KEGGKEGG_AXON_GUIDANCE    KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS    KEGG_REGULATION_OF_ACTIN_CYTOSKELETON   
NDEx NetworkLIMK2
Atlas of Cancer Signalling NetworkLIMK2
Wikipedia pathwaysLIMK2
Orthology - Evolution
OrthoDB3985
GeneTree (enSembl)ENSG00000182541
Phylogenetic Trees/Animal Genes : TreeFamLIMK2
Homologs : HomoloGeneLIMK2
Homology/Alignments : Family Browser (UCSC)LIMK2
Gene fusions - Rearrangements
Fusion : MitelmanLIMK2::ATXN10 [22q12.2/22q13.31]  
Fusion : MitelmanLIMK2::CDC45 [22q12.2/22q11.21]  
Fusion : MitelmanLIMK2::OSBP2 [22q12.2/22q12.2]  
Fusion : MitelmanLIMK2::RUFY1 [22q12.2/5q35.3]  
Fusion : MitelmanSFI1::LIMK2 [22q12.2/22q12.2]  
Fusion : QuiverLIMK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIMK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIMK2
dbVarLIMK2
ClinVarLIMK2
MonarchLIMK2
1000_GenomesLIMK2 
Exome Variant ServerLIMK2
GNOMAD BrowserENSG00000182541
Varsome BrowserLIMK2
ACMGLIMK2 variants
VarityP53671
Genomic Variants (DGV)LIMK2 [DGVbeta]
DECIPHERLIMK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLIMK2 
Mutations
ICGC Data PortalLIMK2 
TCGA Data PortalLIMK2 
Broad Tumor PortalLIMK2
OASIS PortalLIMK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIMK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLIMK2
Mutations and Diseases : HGMDLIMK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLIMK2
DgiDB (Drug Gene Interaction Database)LIMK2
DoCM (Curated mutations)LIMK2
CIViC (Clinical Interpretations of Variants in Cancer)LIMK2
Cancer3DLIMK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601988   
Orphanet
DisGeNETLIMK2
MedgenLIMK2
Genetic Testing Registry LIMK2
NextProtP53671 [Medical]
GENETestsLIMK2
Target ValidationLIMK2
Huge Navigator LIMK2 [HugePedia]
ClinGenLIMK2
Clinical trials, drugs, therapy
MyCancerGenomeLIMK2
Protein Interactions : CTDLIMK2
Pharm GKB GenePA30387
PharosP53671
Clinical trialLIMK2
Miscellaneous
canSAR (ICR)LIMK2
HarmonizomeLIMK2
ARCHS4LIMK2
DataMed IndexLIMK2
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLIMK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:40:51 CET 2022

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