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LIMK2 (LIM domain kinase 2)

Identity

Other alias-
HGNC (Hugo) LIMK2
LocusID (NCBI) 3985
Atlas_Id 41160
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31644348 and ends at 31673624 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LIMK2 (22q12.2) / ATG2A (11q13.1)LIMK2 (22q12.2) / ATXN10 (22q13.31)LIMK2 (22q12.2) / CDC45 (22q11.21)
LIMK2 (22q12.2) / OSBP2 (22q12.2)LIMK2 (22q12.2) / RUFY1 (5q35.3)SFI1 (22q12.2) / LIMK2 (22q12.2)
LIMK2 22q12.2 / ATXN10 22q13.31LIMK2 22q12.2 / CDC45 22q11.21LIMK2 22q12.2 / OSBP2 22q12.2
LIMK2 22q12.2 / RUFY1 5q35.3SFI1 22q12.2 / LIMK2 22q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIMK2   6614
Cards
Entrez_Gene (NCBI)LIMK2  3985  LIM domain kinase 2
Aliases
GeneCards (Weizmann)LIMK2
Ensembl hg19 (Hinxton)ENSG00000182541 [Gene_View]  chr22:31644348-31673624 [Contig_View]  LIMK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182541 [Gene_View]  chr22:31644348-31673624 [Contig_View]  LIMK2 [Vega]
ICGC DataPortalENSG00000182541
TCGA cBioPortalLIMK2
AceView (NCBI)LIMK2
Genatlas (Paris)LIMK2
WikiGenes3985
SOURCE (Princeton)LIMK2
Genetics Home Reference (NIH)LIMK2
Genomic and cartography
GoldenPath hg19 (UCSC)LIMK2  -     chr22:31644348-31673624 +  22q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIMK2  -     22q12.2   [Description]    (hg38-Dec_2013)
EnsemblLIMK2 - 22q12.2 [CytoView hg19]  LIMK2 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBILIMK2 [Mapview hg19]  LIMK2 [Mapview hg38]
OMIM601988   
Gene and transcription
Genbank (Entrez)AB451269 AB451396 AK092838 AK093554 AK291640
RefSeq transcript (Entrez)NM_001031801 NM_005569 NM_016733
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_029895 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)LIMK2
Cluster EST : UnigeneHs.474596 [ NCBI ]
CGAP (NCI)Hs.474596
Alternative Splicing GalleryENSG00000182541
Gene ExpressionLIMK2 [ NCBI-GEO ]   LIMK2 [ EBI - ARRAY_EXPRESS ]   LIMK2 [ SEEK ]   LIMK2 [ MEM ]
Gene Expression Viewer (FireBrowse)LIMK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3985
GTEX Portal (Tissue expression)LIMK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53671   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53671  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53671
Splice isoforms : SwissVarP53671
PhosPhoSitePlusP53671
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)    PDZ (PS50106)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    PDZ    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)    PDZ (PF00595)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam00412    pfam00595    pfam07714   
Domain families : Smart (EMBL)LIM (SM00132)  PDZ (SM00228)  
Conserved Domain (NCBI)LIMK2
DMDM Disease mutations3985
Blocks (Seattle)LIMK2
PDB (SRS)1X6A    4TPT   
PDB (PDBSum)1X6A    4TPT   
PDB (IMB)1X6A    4TPT   
PDB (RSDB)1X6A    4TPT   
Structural Biology KnowledgeBase1X6A    4TPT   
SCOP (Structural Classification of Proteins)1X6A    4TPT   
CATH (Classification of proteins structures)1X6A    4TPT   
SuperfamilyP53671
Human Protein AtlasENSG00000182541
Peptide AtlasP53671
HPRD03585
IPIIPI00022872   IPI00100853   IPI00903271   IPI00908836   IPI00892965   IPI00025698   IPI00894436   
Protein Interaction databases
DIP (DOE-UCLA)P53671
IntAct (EBI)P53671
FunCoupENSG00000182541
BioGRIDLIMK2
STRING (EMBL)LIMK2
ZODIACLIMK2
Ontologies - Pathways
QuickGOP53671
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cis-Golgi network  protein phosphorylation  spermatogenesis  zinc ion binding  phosphorylation  protein heterodimerization activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cis-Golgi network  protein phosphorylation  spermatogenesis  zinc ion binding  phosphorylation  protein heterodimerization activity  
Pathways : KEGGAxon guidance    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton   
NDEx NetworkLIMK2
Atlas of Cancer Signalling NetworkLIMK2
Wikipedia pathwaysLIMK2
Orthology - Evolution
OrthoDB3985
GeneTree (enSembl)ENSG00000182541
Phylogenetic Trees/Animal Genes : TreeFamLIMK2
HOVERGENP53671
HOGENOMP53671
Homologs : HomoloGeneLIMK2
Homology/Alignments : Family Browser (UCSC)LIMK2
Gene fusions - Rearrangements
Fusion : MitelmanLIMK2/ATXN10 [22q12.2/22q13.31]  
Fusion : MitelmanLIMK2/CDC45 [22q12.2/22q11.21]  [t(22;22)(q11;q12)]  
Fusion : MitelmanLIMK2/OSBP2 [22q12.2/22q12.2]  [t(22;22)(q12;q12)]  
Fusion : MitelmanLIMK2/RUFY1 [22q12.2/5q35.3]  [t(5;22)(q35;q12)]  
Fusion : MitelmanSFI1/LIMK2 [22q12.2/22q12.2]  [t(22;22)(q12;q12)]  
Fusion: TCGALIMK2 22q12.2 ATXN10 22q13.31 HNSC
Fusion: TCGALIMK2 22q12.2 CDC45 22q11.21 BLCA
Fusion: TCGALIMK2 22q12.2 OSBP2 22q12.2 BRCA
Fusion: TCGALIMK2 22q12.2 RUFY1 5q35.3 BRCA
Fusion: TCGASFI1 22q12.2 LIMK2 22q12.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIMK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIMK2
dbVarLIMK2
ClinVarLIMK2
1000_GenomesLIMK2 
Exome Variant ServerLIMK2
ExAC (Exome Aggregation Consortium)LIMK2 (select the gene name)
Genetic variants : HAPMAP3985
Genomic Variants (DGV)LIMK2 [DGVbeta]
DECIPHER (Syndromes)22:31644348-31673624  ENSG00000182541
CONAN: Copy Number AnalysisLIMK2 
Mutations
ICGC Data PortalLIMK2 
TCGA Data PortalLIMK2 
Broad Tumor PortalLIMK2
OASIS PortalLIMK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIMK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLIMK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LIMK2
DgiDB (Drug Gene Interaction Database)LIMK2
DoCM (Curated mutations)LIMK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIMK2 (select a term)
intoGenLIMK2
Cancer3DLIMK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601988   
Orphanet
MedgenLIMK2
Genetic Testing Registry LIMK2
NextProtP53671 [Medical]
TSGene3985
GENETestsLIMK2
Huge Navigator LIMK2 [HugePedia]
snp3D : Map Gene to Disease3985
BioCentury BCIQLIMK2
ClinGenLIMK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3985
Chemical/Pharm GKB GenePA30387
Clinical trialLIMK2
Miscellaneous
canSAR (ICR)LIMK2 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIMK2
EVEXLIMK2
GoPubMedLIMK2
iHOPLIMK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:07:03 CEST 2017

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