LIMS1 (LIM zinc finger domain containing 1)

2007-02-01 Affiliation

Identity

HGNC

LIMS1

LOCATION

2q12.3

LOCUSID

3987

ALIAS

PINCH,PINCH-1,PINCH1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3987
MIM: 602567
HGNC: 6616
Ensembl: ENSG00000169756

Variants:

dbSNP: 3987
ClinVar: 3987
TCGA: ENSG00000169756
COSMIC: LIMS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169756	ENST00000332345	P48059
ENSG00000169756	ENST00000338045	P48059
ENSG00000169756	ENST00000393310	P48059
ENSG00000169756	ENST00000409441	P48059
ENSG00000169756	ENST00000410093	P48059
ENSG00000169756	ENST00000414829	F8WC86
ENSG00000169756	ENST00000422797	F8WE10
ENSG00000169756	ENST00000428064	C9JF46
ENSG00000169756	ENST00000434274	F8WB59
ENSG00000169756	ENST00000542845	A0A0M3HER1
ENSG00000169756	ENST00000544547	P48059

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-extracellular matrix interactions	REACTOME	R-HSA-446353
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	REACTOME	R-HSA-446388

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14551191	2003	PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival.	75
12432066	2002	Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites.	60
19074270	2008	The structural basis of integrin-linked kinase-PINCH interactions.	35
18063582	2008	PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells.	33
17656471	2007	PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase.	26
15941716	2005	Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival.	20
25647720	2015	Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples.	14
16273248	2005	Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis.	10
18459134	2008	Novel expression of PINCH in the central nervous system and its potential as a biomarker for human immunodeficiency virus-associated neurodegeneration.	10
20689998	2011	Neuronal PINCH is regulated by TNF-α and is required for neurite extension.	9

Citation

Dessen P

LIMS1 (LIM zinc finger domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45926/lims1