| Written | 2011-07 | Yung-Ming Jeng |
| Department of Biochemistry, Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan |
| Identity |
| Alias (NCBI) | CSDD2 | FLJ16517 | Lin28.2 |
| HGNC (Hugo) | LIN28B |
| HGNC Alias symb | FLJ16517 | CSDD2 |
| HGNC Previous name | lin-28 homolog B (C. elegans) |
| LocusID (NCBI) | 389421 |
| Atlas_Id | 45723 |
| Location | 6q16.3 [Link to chromosome band 6q16] |
| Location_base_pair | Starts at 104957107 and ends at 105083332 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping LIN28B.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| LIN28B (6q16.3)::STX7 (6q23.2) |
| Note | Size: 146,72 kb. Orientation: plus strand. |
| DNA/RNA |
| Description | The gene spans over 125 kb on plus strand; 4 exons. |
| Transcription | The gene is mainly expressed in fetal tissues and not expressed in adult tissue and reexpressed in cancer tissue. |
| Protein |
| Description | Lin28B is an oncofetal RNA-binding protein. Lin-28B protein consists of two domains that contain RNA-binding motif: the N-terminal cold shock domain and a pair of retroviral-type CCHC zinc fingers. It inhibits biosynthesis of let-7 microRNA through binding to the 5'-GGAG-3' motif in the terminal loop of pre-let-7 and promoting terminal uridylation of let-7 precusor by |
| Expression | Cytoplasm. |
| Function | It inhibits biosynthesis of let-7 microRNA through promoting terminal uridylation of let-7 precusor by TUTase4. |
| Homology | |
| Mutations |
| Note | No somatic mutation of Lin28B was identified in cancer. |
| Implicated in |
| Note | |
| Entity | Hepatocellular carcinoma |
| Note | Lin28B expression is more frequently noted in high-grade hepatocellular carcinoma with high alpha-fetoprotein levels. Knockdown of Lin28B by RNA interference in the HCC cell line suppressed proliferation in vitro and reduced in vivo tumor growth in NOD/SCID mice. In contrast, overexpression of Lin28B in the HCC cell line enhanced tumorigenicity. Overexpression of Lin28B also induced epithelial-mesenchymal transition in HA22T cells and hence, invasion capacity. |
| Entity | Colorectal cancer |
| Note | Lin28B is overexpressed in colorectal cancer. It promotes cell migration, invasion and transforms immortalized colonic epithelial cells. In addition, constitutive LIN28B expression increases expression of intestinal stem cell markers LGR5 and PROM1 in the presence of let-7 restoration. |
| Entity | Ovarian cancer |
| Note | Lin28B is overexpressed in high grade serous ovarian cancer. Pleomorphism in Lin28B promoter region is associated with susceptibility to epithelium ovarian cancer. Patients with high Lin28B ovarian cancer had shorter progression-free and overall survival than those with low Lin28B ovarian cancer. |
| Entity | Age at menarche |
| Note | A sequence variation in Lin28B is identified as the SNP most significant associated with age at menarche in one genome wide study. Besides, a meta-analysis of 32 genome-wide association studies in 87802 women found polymorphism of Lin28B is strongly associated with age at menarche. Knockout mice of Lin28B also show delay in puberty onset. |
| Entity | Body height |
| Note | A LIN28B SNP, rs314277, is associated with final body height. |
| Bibliography |
| Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. |
| He C, Kraft P, Chen C, Buring JE, Pare G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI. |
| Nat Genet. 2009 Jun;41(6):724-8. Epub 2009 May 17. |
| PMID 19448621 |
| Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. |
| Helland A, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ; Australian Ovarian Cancer Study Group, Pearson RB, Borresen-Dale AL, Huntsman DG, deFazio A, Creighton CJ, Smyth GK, Bowtell DD. |
| PLoS One. 2011 Apr 13;6(4):e18064. |
| PMID 21533284 |
| Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. |
| Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. |
| Mol Cell. 2008 Oct 24;32(2):276-84. |
| PMID 18951094 |
| LIN28B promotes colon cancer progression and metastasis. |
| King CE, Cuatrecasas M, Castells A, Sepulveda AR, Lee JS, Rustgi AK. |
| Cancer Res. 2011 Jun 15;71(12):4260-8. Epub 2011 Apr 21. |
| PMID 21512136 |
| LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms. |
| King CE, Wang L, Winograd R, Madison BB, Mongroo PS, Johnstone CN, Rustgi AK. |
| Oncogene. 2011 May 30. [Epub ahead of print] |
| PMID 21625210 |
| Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II. |
| Lu L, Katsaros D, Shaverdashvili K, Qian B, Wu Y, de la Longrais IA, Preti M, Menato G, Yu H. |
| Eur J Cancer. 2009 Aug;45(12):2212-8. Epub 2009 May 26. |
| PMID 19477633 |
| Lin28 promotes transformation and is associated with advanced human malignancies. |
| Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ. |
| Nat Genet. 2009 Jul;41(7):843-8. Epub 2009 May 31. |
| PMID 19483683 |
| Citation |
| This paper should be referenced as such : |
| Jeng, YM. LIN28B (lin-28 homolog B (C |
| elegans)) |
| Atlas Genet Cytogenet Oncol Haematol. 2012;16(1):20-21. |
| Free journal version : [ pdf ] [ DOI ] |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Oct 8 21:21:17 CEST 2021 |
For comments and suggestions or contributions, please contact us