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LIN7A (lin-7 homolog A, crumbs cell polarity complex component)

Identity

Alias (NCBI)LIN-7A
LIN7
MALS-1
MALS1
TIP-33
VELI1
HGNC (Hugo) LIN7A
HGNC Alias symbMALS-1
TIP-33
LIN-7A
VELI1
HGNC Alias namemammalian LIN-7 1
HGNC Previous namelin-7 homolog A (C. elegans)
LocusID (NCBI) 8825
Atlas_Id 56624
Location 12q21.31  [Link to chromosome band 12q21]
Location_base_pair Starts at 80792521 and ends at 80937915 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LIN7A (12q21.31) / TRHDE (12q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LIN7A   17787
Cards
Entrez_Gene (NCBI)LIN7A    lin-7 homolog A, crumbs cell polarity complex component
AliasesLIN-7A; LIN7; MALS-1; MALS1; 
TIP-33; VELI1
GeneCards (Weizmann)LIN7A
Ensembl hg19 (Hinxton)ENSG00000111052 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111052 [Gene_View]  ENSG00000111052 [Sequence]  chr12:80792521-80937915 [Contig_View]  LIN7A [Vega]
ICGC DataPortalENSG00000111052
TCGA cBioPortalLIN7A
AceView (NCBI)LIN7A
Genatlas (Paris)LIN7A
SOURCE (Princeton)LIN7A
Genetics Home Reference (NIH)LIN7A
Genomic and cartography
GoldenPath hg38 (UCSC)LIN7A  -     chr12:80792521-80937915 -  12q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LIN7A  -     12q21.31   [Description]    (hg19-Feb_2009)
GoldenPathLIN7A - 12q21.31 [CytoView hg19]  LIN7A - 12q21.31 [CytoView hg38]
ImmunoBaseENSG00000111052
Genome Data Viewer NCBILIN7A [Mapview hg19]  
OMIM603380   
Gene and transcription
Genbank (Entrez)AF028826 AF087693 AF173081 AK022997 AK309256
RefSeq transcript (Entrez)NM_001324423 NM_004664
Consensus coding sequences : CCDS (NCBI)LIN7A
Gene ExpressionLIN7A [ NCBI-GEO ]   LIN7A [ EBI - ARRAY_EXPRESS ]   LIN7A [ SEEK ]   LIN7A [ MEM ]
Gene Expression Viewer (FireBrowse)LIN7A [ Firebrowse - Broad ]
GenevisibleExpression of LIN7A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8825
GTEX Portal (Tissue expression)LIN7A
Human Protein AtlasENSG00000111052-LIN7A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14910   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14910  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14910
PhosPhoSitePlusO14910
Domaine pattern : Prosite (Expaxy)L27 (PS51022)    PDZ (PS50106)   
Domains : Interpro (EBI)L27_C    L27_dom    L27_dom_sf    LIN7    PDZ    PDZ_sf   
Domain families : Pfam (Sanger)L27 (PF02828)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam02828    pfam00595   
Domain families : Smart (EMBL)L27 (SM00569)  PDZ (SM00228)  
Conserved Domain (NCBI)LIN7A
SuperfamilyO14910
AlphaFold pdb e-kbO14910   
Human Protein Atlas [tissue]ENSG00000111052-LIN7A [tissue]
HPRD04542
Protein Interaction databases
DIP (DOE-UCLA)O14910
IntAct (EBI)O14910
BioGRIDLIN7A
STRING (EMBL)LIN7A
ZODIACLIN7A
Ontologies - Pathways
QuickGOO14910
Ontology : AmiGOprotein binding  plasma membrane  cell-cell junction  bicellular tight junction  neurotransmitter transport  exocytosis  neurotransmitter secretion  protein transport  basolateral plasma membrane  maintenance of epithelial cell apical/basal polarity  synapse  synaptic vesicle transport  inner ear development  protein-containing complex assembly  extracellular exosome  L27 domain binding  L27 domain binding  MPP7-DLG1-LIN7 complex  presynapse  postsynaptic density membrane  protein localization to basolateral plasma membrane  
Ontology : EGO-EBIprotein binding  plasma membrane  cell-cell junction  bicellular tight junction  neurotransmitter transport  exocytosis  neurotransmitter secretion  protein transport  basolateral plasma membrane  maintenance of epithelial cell apical/basal polarity  synapse  synaptic vesicle transport  inner ear development  protein-containing complex assembly  extracellular exosome  L27 domain binding  L27 domain binding  MPP7-DLG1-LIN7 complex  presynapse  postsynaptic density membrane  protein localization to basolateral plasma membrane  
Pathways : BIOCARTAChaperones modulate interferon Signaling Pathway [Genes]   
NDEx NetworkLIN7A
Atlas of Cancer Signalling NetworkLIN7A
Wikipedia pathwaysLIN7A
Orthology - Evolution
OrthoDB8825
GeneTree (enSembl)ENSG00000111052
Phylogenetic Trees/Animal Genes : TreeFamLIN7A
Homologs : HomoloGeneLIN7A
Homology/Alignments : Family Browser (UCSC)LIN7A
Gene fusions - Rearrangements
Fusion : QuiverLIN7A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIN7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIN7A
dbVarLIN7A
ClinVarLIN7A
MonarchLIN7A
1000_GenomesLIN7A 
Exome Variant ServerLIN7A
GNOMAD BrowserENSG00000111052
Varsome BrowserLIN7A
ACMGLIN7A variants
VarityO14910
Genomic Variants (DGV)LIN7A [DGVbeta]
DECIPHERLIN7A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLIN7A 
Mutations
ICGC Data PortalLIN7A 
TCGA Data PortalLIN7A 
Broad Tumor PortalLIN7A
OASIS PortalLIN7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIN7A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLIN7A
Mutations and Diseases : HGMDLIN7A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLIN7A
DgiDB (Drug Gene Interaction Database)LIN7A
DoCM (Curated mutations)LIN7A
CIViC (Clinical Interpretations of Variants in Cancer)LIN7A
Cancer3DLIN7A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603380   
Orphanet
DisGeNETLIN7A
MedgenLIN7A
Genetic Testing Registry LIN7A
NextProtO14910 [Medical]
GENETestsLIN7A
Target ValidationLIN7A
Huge Navigator LIN7A [HugePedia]
ClinGenLIN7A
Clinical trials, drugs, therapy
MyCancerGenomeLIN7A
Protein Interactions : CTDLIN7A
Pharm GKB GenePA134881936
PharosO14910
Clinical trialLIN7A
Miscellaneous
canSAR (ICR)LIN7A
HarmonizomeLIN7A
DataMed IndexLIN7A
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLIN7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:15:59 CEST 2021

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