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LIN7A (lin-7 homolog A, crumbs cell polarity complex component)

Identity

Alias_nameslin-7 homolog A (C. elegans)
Alias_symbol (synonym)MALS-1
TIP-33
LIN-7A
VELI1
Other aliasLIN7
HGNC (Hugo) LIN7A
LocusID (NCBI) 8825
Atlas_Id 56624
Location 12q21.31  [Link to chromosome band 12q21]
Location_base_pair Starts at 81186300 and ends at 81331694 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LIN7A (12q21.31) / TRHDE (12q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIN7A   17787
Cards
Entrez_Gene (NCBI)LIN7A  8825  lin-7 homolog A, crumbs cell polarity complex component
AliasesLIN-7A; LIN7; MALS-1; TIP-33; 
VELI1
GeneCards (Weizmann)LIN7A
Ensembl hg19 (Hinxton)ENSG00000111052 [Gene_View]  chr12:81186300-81331694 [Contig_View]  LIN7A [Vega]
Ensembl hg38 (Hinxton)ENSG00000111052 [Gene_View]  chr12:81186300-81331694 [Contig_View]  LIN7A [Vega]
ICGC DataPortalENSG00000111052
TCGA cBioPortalLIN7A
AceView (NCBI)LIN7A
Genatlas (Paris)LIN7A
WikiGenes8825
SOURCE (Princeton)LIN7A
Genetics Home Reference (NIH)LIN7A
Genomic and cartography
GoldenPath hg19 (UCSC)LIN7A  -     chr12:81186300-81331694 -  12q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIN7A  -     12q21.31   [Description]    (hg38-Dec_2013)
EnsemblLIN7A - 12q21.31 [CytoView hg19]  LIN7A - 12q21.31 [CytoView hg38]
Mapping of homologs : NCBILIN7A [Mapview hg19]  LIN7A [Mapview hg38]
OMIM603380   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001324423 NM_004664
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LIN7A
Cluster EST : UnigeneHs.586760 [ NCBI ]
CGAP (NCI)Hs.586760
Alternative Splicing GalleryENSG00000111052
Gene ExpressionLIN7A [ NCBI-GEO ]   LIN7A [ EBI - ARRAY_EXPRESS ]   LIN7A [ SEEK ]   LIN7A [ MEM ]
Gene Expression Viewer (FireBrowse)LIN7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8825
GTEX Portal (Tissue expression)LIN7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14910   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14910  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14910
Splice isoforms : SwissVarO14910
PhosPhoSitePlusO14910
Domaine pattern : Prosite (Expaxy)L27 (PS51022)    PDZ (PS50106)   
Domains : Interpro (EBI)L27_C    L27_dom    PDZ   
Domain families : Pfam (Sanger)L27 (PF02828)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam02828    pfam00595   
Domain families : Smart (EMBL)L27 (SM00569)  PDZ (SM00228)  
Conserved Domain (NCBI)LIN7A
DMDM Disease mutations8825
Blocks (Seattle)LIN7A
SuperfamilyO14910
Human Protein AtlasENSG00000111052
Peptide AtlasO14910
HPRD04542
IPIIPI00005824   IPI01021937   IPI01021653   IPI01022526   
Protein Interaction databases
DIP (DOE-UCLA)O14910
IntAct (EBI)O14910
FunCoupENSG00000111052
BioGRIDLIN7A
STRING (EMBL)LIN7A
ZODIACLIN7A
Ontologies - Pathways
QuickGOO14910
Ontology : AmiGOprotein binding  plasma membrane  cell-cell junction  bicellular tight junction  protein complex assembly  exocytosis  neurotransmitter secretion  neurotransmitter secretion  postsynaptic density  protein transport  basolateral plasma membrane  neuron projection  maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  synaptic vesicle transport  inner ear development  extracellular exosome  L27 domain binding  presynapse  protein localization to basolateral plasma membrane  
Ontology : EGO-EBIprotein binding  plasma membrane  cell-cell junction  bicellular tight junction  protein complex assembly  exocytosis  neurotransmitter secretion  neurotransmitter secretion  postsynaptic density  protein transport  basolateral plasma membrane  neuron projection  maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  synaptic vesicle transport  inner ear development  extracellular exosome  L27 domain binding  presynapse  protein localization to basolateral plasma membrane  
Pathways : BIOCARTAChaperones modulate interferon Signaling Pathway [Genes]   
NDEx NetworkLIN7A
Atlas of Cancer Signalling NetworkLIN7A
Wikipedia pathwaysLIN7A
Orthology - Evolution
OrthoDB8825
GeneTree (enSembl)ENSG00000111052
Phylogenetic Trees/Animal Genes : TreeFamLIN7A
HOVERGENO14910
HOGENOMO14910
Homologs : HomoloGeneLIN7A
Homology/Alignments : Family Browser (UCSC)LIN7A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIN7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIN7A
dbVarLIN7A
ClinVarLIN7A
1000_GenomesLIN7A 
Exome Variant ServerLIN7A
ExAC (Exome Aggregation Consortium)LIN7A (select the gene name)
Genetic variants : HAPMAP8825
Genomic Variants (DGV)LIN7A [DGVbeta]
DECIPHER (Syndromes)12:81186300-81331694  ENSG00000111052
CONAN: Copy Number AnalysisLIN7A 
Mutations
ICGC Data PortalLIN7A 
TCGA Data PortalLIN7A 
Broad Tumor PortalLIN7A
OASIS PortalLIN7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIN7A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLIN7A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LIN7A
DgiDB (Drug Gene Interaction Database)LIN7A
DoCM (Curated mutations)LIN7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIN7A (select a term)
intoGenLIN7A
Cancer3DLIN7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603380   
Orphanet
MedgenLIN7A
Genetic Testing Registry LIN7A
NextProtO14910 [Medical]
TSGene8825
GENETestsLIN7A
Huge Navigator LIN7A [HugePedia]
snp3D : Map Gene to Disease8825
BioCentury BCIQLIN7A
ClinGenLIN7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8825
Chemical/Pharm GKB GenePA134881936
Clinical trialLIN7A
Miscellaneous
canSAR (ICR)LIN7A (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIN7A
EVEXLIN7A
GoPubMedLIN7A
iHOPLIN7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:51 CET 2017

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