Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LIN7B (lin-7 homolog B, crumbs cell polarity complex component)

Identity

Alias (NCBI)LIN-7B
MALS-2
MALS2
VELI2
HGNC (Hugo) LIN7B
HGNC Alias symbMALS-2
LIN-7B
VELI2
HGNC Previous namelin-7 homolog B (C. elegans)
LocusID (NCBI) 64130
Atlas_Id 65280
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49114361 and ends at 49118460 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LIN7B   17788
Cards
Entrez_Gene (NCBI)LIN7B    lin-7 homolog B, crumbs cell polarity complex component
AliasesLIN-7B; MALS-2; MALS2; VELI2
GeneCards (Weizmann)LIN7B
Ensembl hg19 (Hinxton)ENSG00000104863 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104863 [Gene_View]  ENSG00000104863 [Sequence]  chr19:49114361-49118460 [Contig_View]  LIN7B [Vega]
ICGC DataPortalENSG00000104863
TCGA cBioPortalLIN7B
AceView (NCBI)LIN7B
Genatlas (Paris)LIN7B
SOURCE (Princeton)LIN7B
Genetics Home Reference (NIH)LIN7B
Genomic and cartography
GoldenPath hg38 (UCSC)LIN7B  -     chr19:49114361-49118460 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LIN7B  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathLIN7B - 19q13.33 [CytoView hg19]  LIN7B - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000104863
genome Data Viewer NCBILIN7B [Mapview hg19]  
OMIM612331   
Gene and transcription
Genbank (Entrez)AF311862 AY358744 BC027618 BM069859
RefSeq transcript (Entrez)NM_001308419 NM_022165
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LIN7B
Alternative Splicing GalleryENSG00000104863
Gene ExpressionLIN7B [ NCBI-GEO ]   LIN7B [ EBI - ARRAY_EXPRESS ]   LIN7B [ SEEK ]   LIN7B [ MEM ]
Gene Expression Viewer (FireBrowse)LIN7B [ Firebrowse - Broad ]
GenevisibleExpression of LIN7B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64130
GTEX Portal (Tissue expression)LIN7B
Human Protein AtlasENSG00000104863-LIN7B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAP6
Splice isoforms : SwissVarQ9HAP6
PhosPhoSitePlusQ9HAP6
Domaine pattern : Prosite (Expaxy)L27 (PS51022)    PDZ (PS50106)   
Domains : Interpro (EBI)L27_C    L27_dom    L27_dom_sf    LIN7    PDZ    PDZ_sf   
Domain families : Pfam (Sanger)L27 (PF02828)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam02828    pfam00595   
Domain families : Smart (EMBL)L27 (SM00569)  PDZ (SM00228)  
Conserved Domain (NCBI)LIN7B
Blocks (Seattle)LIN7B
PDB (RSDB)2DKR   
PDB Europe2DKR   
PDB (PDBSum)2DKR   
PDB (IMB)2DKR   
Structural Biology KnowledgeBase2DKR   
SCOP (Structural Classification of Proteins)2DKR   
CATH (Classification of proteins structures)2DKR   
SuperfamilyQ9HAP6
Human Protein Atlas [tissue]ENSG00000104863-LIN7B [tissue]
Peptide AtlasQ9HAP6
HPRD10040
IPIIPI00005566   IPI00792650   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAP6
IntAct (EBI)Q9HAP6
BioGRIDLIN7B
STRING (EMBL)LIN7B
ZODIACLIN7B
Ontologies - Pathways
QuickGOQ9HAP6
Ontology : AmiGOplasma membrane  cell-cell junction  bicellular tight junction  exocytosis  neurotransmitter secretion  neurotransmitter secretion  postsynaptic density  protein transport  basolateral plasma membrane  protein domain specific binding  PDZ domain binding  neuron projection  maintenance of epithelial cell apical/basal polarity  synapse  postsynaptic membrane  L27 domain binding  MPP7-DLG1-LIN7 complex  presynapse  protein localization to basolateral plasma membrane  
Ontology : EGO-EBIplasma membrane  cell-cell junction  bicellular tight junction  exocytosis  neurotransmitter secretion  neurotransmitter secretion  postsynaptic density  protein transport  basolateral plasma membrane  protein domain specific binding  PDZ domain binding  neuron projection  maintenance of epithelial cell apical/basal polarity  synapse  postsynaptic membrane  L27 domain binding  MPP7-DLG1-LIN7 complex  presynapse  protein localization to basolateral plasma membrane  
NDEx NetworkLIN7B
Atlas of Cancer Signalling NetworkLIN7B
Wikipedia pathwaysLIN7B
Orthology - Evolution
OrthoDB64130
GeneTree (enSembl)ENSG00000104863
Phylogenetic Trees/Animal Genes : TreeFamLIN7B
HOGENOMQ9HAP6
Homologs : HomoloGeneLIN7B
Homology/Alignments : Family Browser (UCSC)LIN7B
Gene fusions - Rearrangements
Fusion : QuiverLIN7B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIN7B [hg38]
dbVarLIN7B
ClinVarLIN7B
MonarchLIN7B
1000_GenomesLIN7B 
Exome Variant ServerLIN7B
GNOMAD BrowserENSG00000104863
Varsome BrowserLIN7B
Genomic Variants (DGV)LIN7B [DGVbeta]
DECIPHERLIN7B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLIN7B 
Mutations
ICGC Data PortalLIN7B 
TCGA Data PortalLIN7B 
Broad Tumor PortalLIN7B
OASIS PortalLIN7B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIN7B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLIN7B
Mutations and Diseases : HGMDLIN7B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LIN7B
DgiDB (Drug Gene Interaction Database)LIN7B
DoCM (Curated mutations)LIN7B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIN7B (select a term)
intoGenLIN7B
Cancer3DLIN7B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612331   
Orphanet
DisGeNETLIN7B
MedgenLIN7B
Genetic Testing Registry LIN7B
NextProtQ9HAP6 [Medical]
GENETestsLIN7B
Target ValidationLIN7B
Huge Navigator LIN7B [HugePedia]
ClinGenLIN7B
Clinical trials, drugs, therapy
MyCancerGenomeLIN7B
Protein Interactions : CTD
Pharm GKB GenePA134914453
Clinical trialLIN7B
Miscellaneous
canSAR (ICR)LIN7B (select the gene name)
HarmonizomeLIN7B
DataMed IndexLIN7B
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIN7B
EVEXLIN7B
GoPubMedLIN7B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 5 16:59:55 CET 2020
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.