LIN7C (lin-7 homolog C, crumbs cell polarity complex component)

2015-11-01  

Identity

HGNC
LOCATION
11p14.1
LOCUSID
ALIAS
LIN-7-C,LIN-7C,MALS-3,MALS3,VELI3
FUSION GENES

Other Information

Locus ID:

NCBI: 55327
MIM: 612332
HGNC: 17789
Ensembl: ENSG00000148943

Variants:

dbSNP: 55327
ClinVar: 55327
TCGA: ENSG00000148943
COSMIC: LIN7C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148943ENST00000278193Q9NUP9
ENSG00000148943ENST00000524596G3V1D4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202153972010Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.44
172372262007The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.24
182866322008Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.12
182866322008Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.12
161479932005A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes.11
179428932007Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma.7
185431222008Association study of theta EEG asymmetry and brain-derived neurotrophic factor gene variants in childhood-onset mood disorder.5
207027752010Structural basis for tandem L27 domain-mediated polymerization.5
249612842014Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells.5

Citation

Dessen P

LIN7C (lin-7 homolog C, crumbs cell polarity complex component)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/55505/lin7c