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LIN7C (lin-7 homolog C, crumbs cell polarity complex component)

Identity

Alias_nameslin-7 homolog C (C. elegans)
Alias_symbol (synonym)MALS-3
Lin7c
LIN-7C
LIN-7-C
VELI3
FLJ11215
Other aliasMALS3
HGNC (Hugo) LIN7C
LocusID (NCBI) 55327
Atlas_Id 55505
Location 11p14.1  [Link to chromosome band 11p14]
Location_base_pair Starts at 27515965 and ends at 27528326 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LIN7C (11p14.1) / CD55 (1q32.2)LIN7C (11p14.1) / RAB31 (18p11.22)LIN7C (11p14.1) / SLCO1A2 (12p12.1)
UNC5C (4q22.3) / LIN7C (11p14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIN7C   17789
Cards
Entrez_Gene (NCBI)LIN7C  55327  lin-7 homolog C, crumbs cell polarity complex component
AliasesLIN-7-C; LIN-7C; MALS-3; MALS3; 
VELI3
GeneCards (Weizmann)LIN7C
Ensembl hg19 (Hinxton)ENSG00000148943 [Gene_View]  chr11:27515965-27528326 [Contig_View]  LIN7C [Vega]
Ensembl hg38 (Hinxton)ENSG00000148943 [Gene_View]  chr11:27515965-27528326 [Contig_View]  LIN7C [Vega]
ICGC DataPortalENSG00000148943
TCGA cBioPortalLIN7C
AceView (NCBI)LIN7C
Genatlas (Paris)LIN7C
WikiGenes55327
SOURCE (Princeton)LIN7C
Genetics Home Reference (NIH)LIN7C
Genomic and cartography
GoldenPath hg19 (UCSC)LIN7C  -     chr11:27515965-27528326 -  11p14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIN7C  -     11p14.1   [Description]    (hg38-Dec_2013)
EnsemblLIN7C - 11p14.1 [CytoView hg19]  LIN7C - 11p14.1 [CytoView hg38]
Mapping of homologs : NCBILIN7C [Mapview hg19]  LIN7C [Mapview hg38]
OMIM612332   
Gene and transcription
Genbank (Entrez)AF090900 AK002077 AK025540 AK223156 AL833601
RefSeq transcript (Entrez)NM_018362
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)LIN7C
Cluster EST : UnigeneHs.91393 [ NCBI ]
CGAP (NCI)Hs.91393
Alternative Splicing GalleryENSG00000148943
Gene ExpressionLIN7C [ NCBI-GEO ]   LIN7C [ EBI - ARRAY_EXPRESS ]   LIN7C [ SEEK ]   LIN7C [ MEM ]
Gene Expression Viewer (FireBrowse)LIN7C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55327
GTEX Portal (Tissue expression)LIN7C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NUP9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NUP9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NUP9
Splice isoforms : SwissVarQ9NUP9
PhosPhoSitePlusQ9NUP9
Domaine pattern : Prosite (Expaxy)L27 (PS51022)    PDZ (PS50106)   
Domains : Interpro (EBI)L27_C    L27_dom    PDZ   
Domain families : Pfam (Sanger)L27 (PF02828)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam02828    pfam00595   
Domain families : Smart (EMBL)L27 (SM00569)  PDZ (SM00228)  
Conserved Domain (NCBI)LIN7C
DMDM Disease mutations55327
Blocks (Seattle)LIN7C
PDB (SRS)3LRA   
PDB (PDBSum)3LRA   
PDB (IMB)3LRA   
PDB (RSDB)3LRA   
Structural Biology KnowledgeBase3LRA   
SCOP (Structural Classification of Proteins)3LRA   
CATH (Classification of proteins structures)3LRA   
SuperfamilyQ9NUP9
Human Protein AtlasENSG00000148943
Peptide AtlasQ9NUP9
HPRD17279
IPIIPI00019997   IPI00384069   IPI00983405   
Protein Interaction databases
DIP (DOE-UCLA)Q9NUP9
IntAct (EBI)Q9NUP9
FunCoupENSG00000148943
BioGRIDLIN7C
STRING (EMBL)LIN7C
ZODIACLIN7C
Ontologies - Pathways
QuickGOQ9NUP9
Ontology : AmiGOmorphogenesis of an epithelial sheet  cytoplasm  plasma membrane  plasma membrane  cell-cell junction  bicellular tight junction  exocytosis  neurotransmitter secretion  neurotransmitter secretion  cytoskeletal protein binding  postsynaptic density  protein transport  basolateral plasma membrane  protein domain specific binding  PDZ domain binding  neuron projection  maintenance of epithelial cell apical/basal polarity  synapse  postsynaptic membrane  extracellular exosome  L27 domain binding  MPP7-DLG1-LIN7 complex  presynapse  presynapse  presynapse  protein localization to basolateral plasma membrane  
Ontology : EGO-EBImorphogenesis of an epithelial sheet  cytoplasm  plasma membrane  plasma membrane  cell-cell junction  bicellular tight junction  exocytosis  neurotransmitter secretion  neurotransmitter secretion  cytoskeletal protein binding  postsynaptic density  protein transport  basolateral plasma membrane  protein domain specific binding  PDZ domain binding  neuron projection  maintenance of epithelial cell apical/basal polarity  synapse  postsynaptic membrane  extracellular exosome  L27 domain binding  MPP7-DLG1-LIN7 complex  presynapse  presynapse  presynapse  protein localization to basolateral plasma membrane  
NDEx NetworkLIN7C
Atlas of Cancer Signalling NetworkLIN7C
Wikipedia pathwaysLIN7C
Orthology - Evolution
OrthoDB55327
GeneTree (enSembl)ENSG00000148943
Phylogenetic Trees/Animal Genes : TreeFamLIN7C
HOVERGENQ9NUP9
HOGENOMQ9NUP9
Homologs : HomoloGeneLIN7C
Homology/Alignments : Family Browser (UCSC)LIN7C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIN7C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIN7C
dbVarLIN7C
ClinVarLIN7C
1000_GenomesLIN7C 
Exome Variant ServerLIN7C
ExAC (Exome Aggregation Consortium)LIN7C (select the gene name)
Genetic variants : HAPMAP55327
Genomic Variants (DGV)LIN7C [DGVbeta]
DECIPHER (Syndromes)11:27515965-27528326  ENSG00000148943
CONAN: Copy Number AnalysisLIN7C 
Mutations
ICGC Data PortalLIN7C 
TCGA Data PortalLIN7C 
Broad Tumor PortalLIN7C
OASIS PortalLIN7C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIN7C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLIN7C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LIN7C
DgiDB (Drug Gene Interaction Database)LIN7C
DoCM (Curated mutations)LIN7C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIN7C (select a term)
intoGenLIN7C
Cancer3DLIN7C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612332   
Orphanet
MedgenLIN7C
Genetic Testing Registry LIN7C
NextProtQ9NUP9 [Medical]
TSGene55327
GENETestsLIN7C
Huge Navigator LIN7C [HugePedia]
snp3D : Map Gene to Disease55327
BioCentury BCIQLIN7C
ClinGenLIN7C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55327
Chemical/Pharm GKB GenePA134891786
Clinical trialLIN7C
Miscellaneous
canSAR (ICR)LIN7C (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIN7C
EVEXLIN7C
GoPubMedLIN7C
iHOPLIN7C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:07:04 CEST 2017

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