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LINGO1 (leucine rich repeat and Ig domain containing 1)

Identity

Alias_namesLRRN6A
leucine rich repeat neuronal 6A
Alias_symbol (synonym)FLJ14594
LERN1
Other aliasUNQ201
HGNC (Hugo) LINGO1
LocusID (NCBI) 84894
Atlas_Id 46531
Location 15q24.3  [Link to chromosome band 15q24]
Location_base_pair Starts at 77613024 and ends at 77820900 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANKRD11 (16q24.3) / LINGO1 (15q24.3)CASC4 (15q15.3) / LINGO1 (15q24.3)SCAPER (15q24.3) / LINGO1 (15q24.3)
ANKRD11 16q24.3 / LINGO1 15q24.3SCAPER 15q24.3 / LINGO1 15q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LINGO1   21205
Cards
Entrez_Gene (NCBI)LINGO1  84894  leucine rich repeat and Ig domain containing 1
AliasesLERN1; LRRN6A; UNQ201
GeneCards (Weizmann)LINGO1
Ensembl hg19 (Hinxton)ENSG00000169783 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169783 [Gene_View]  chr15:77613024-77820900 [Contig_View]  LINGO1 [Vega]
ICGC DataPortalENSG00000169783
TCGA cBioPortalLINGO1
AceView (NCBI)LINGO1
Genatlas (Paris)LINGO1
WikiGenes84894
SOURCE (Princeton)LINGO1
Genetics Home Reference (NIH)LINGO1
Genomic and cartography
GoldenPath hg38 (UCSC)LINGO1  -     chr15:77613024-77820900 -  15q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LINGO1  -     15q24.3   [Description]    (hg19-Feb_2009)
EnsemblLINGO1 - 15q24.3 [CytoView hg19]  LINGO1 - 15q24.3 [CytoView hg38]
Mapping of homologs : NCBILINGO1 [Mapview hg19]  LINGO1 [Mapview hg38]
OMIM609791   
Gene and transcription
Genbank (Entrez)AK027500 AK291363 AL109677 AL834260 AY324320
RefSeq transcript (Entrez)NM_001301186 NM_001301187 NM_001301189 NM_001301191 NM_001301192 NM_001301194 NM_001301195 NM_001301197 NM_001301198 NM_001301199 NM_001301200 NM_032808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LINGO1
Cluster EST : UnigeneHs.745412 [ NCBI ]
CGAP (NCI)Hs.745412
Alternative Splicing GalleryENSG00000169783
Gene ExpressionLINGO1 [ NCBI-GEO ]   LINGO1 [ EBI - ARRAY_EXPRESS ]   LINGO1 [ SEEK ]   LINGO1 [ MEM ]
Gene Expression Viewer (FireBrowse)LINGO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84894
GTEX Portal (Tissue expression)LINGO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FE5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FE5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FE5
Splice isoforms : SwissVarQ96FE5
PhosPhoSitePlusQ96FE5
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_5    LRRNT   
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_5 (PF13306)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13306    pfam13855   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  LRR_TYP (SM00369)  LRRNT (SM00013)  
Conserved Domain (NCBI)LINGO1
DMDM Disease mutations84894
Blocks (Seattle)LINGO1
PDB (SRS)2ID5    4OQT   
PDB (PDBSum)2ID5    4OQT   
PDB (IMB)2ID5    4OQT   
PDB (RSDB)2ID5    4OQT   
Structural Biology KnowledgeBase2ID5    4OQT   
SCOP (Structural Classification of Proteins)2ID5    4OQT   
CATH (Classification of proteins structures)2ID5    4OQT   
SuperfamilyQ96FE5
Human Protein AtlasENSG00000169783
Peptide AtlasQ96FE5
HPRD14322
IPIIPI00465325   IPI00795326   IPI00983465   
Protein Interaction databases
DIP (DOE-UCLA)Q96FE5
IntAct (EBI)Q96FE5
FunCoupENSG00000169783
BioGRIDLINGO1
STRING (EMBL)LINGO1
ZODIACLINGO1
Ontologies - Pathways
QuickGOQ96FE5
Ontology : AmiGOepidermal growth factor receptor binding  protein binding  proteinaceous extracellular matrix  extracellular space  plasma membrane  signal transduction  axonogenesis  integral component of membrane  negative regulation of axonogenesis  
Ontology : EGO-EBIepidermal growth factor receptor binding  protein binding  proteinaceous extracellular matrix  extracellular space  plasma membrane  signal transduction  axonogenesis  integral component of membrane  negative regulation of axonogenesis  
NDEx NetworkLINGO1
Atlas of Cancer Signalling NetworkLINGO1
Wikipedia pathwaysLINGO1
Orthology - Evolution
OrthoDB84894
GeneTree (enSembl)ENSG00000169783
Phylogenetic Trees/Animal Genes : TreeFamLINGO1
HOVERGENQ96FE5
HOGENOMQ96FE5
Homologs : HomoloGeneLINGO1
Homology/Alignments : Family Browser (UCSC)LINGO1
Gene fusions - Rearrangements
Fusion : MitelmanANKRD11/LINGO1 [16q24.3/15q24.3]  [t(15;16)(q24;q24)]  
Fusion : MitelmanSCAPER/LINGO1 [15q24.3/15q24.3]  [t(15;15)(q24;q24)]  
Fusion: TCGAANKRD11 16q24.3 LINGO1 15q24.3 BRCA
Fusion: TCGASCAPER 15q24.3 LINGO1 15q24.3 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLINGO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LINGO1
dbVarLINGO1
ClinVarLINGO1
1000_GenomesLINGO1 
Exome Variant ServerLINGO1
ExAC (Exome Aggregation Consortium)LINGO1 (select the gene name)
Genetic variants : HAPMAP84894
Genomic Variants (DGV)LINGO1 [DGVbeta]
DECIPHERLINGO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLINGO1 
Mutations
ICGC Data PortalLINGO1 
TCGA Data PortalLINGO1 
Broad Tumor PortalLINGO1
OASIS PortalLINGO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLINGO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLINGO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LINGO1
DgiDB (Drug Gene Interaction Database)LINGO1
DoCM (Curated mutations)LINGO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LINGO1 (select a term)
intoGenLINGO1
Cancer3DLINGO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609791   
Orphanet
MedgenLINGO1
Genetic Testing Registry LINGO1
NextProtQ96FE5 [Medical]
TSGene84894
GENETestsLINGO1
Target ValidationLINGO1
Huge Navigator LINGO1 [HugePedia]
snp3D : Map Gene to Disease84894
BioCentury BCIQLINGO1
ClinGenLINGO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84894
Chemical/Pharm GKB GenePA162394087
Clinical trialLINGO1
Miscellaneous
canSAR (ICR)LINGO1 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLINGO1
EVEXLINGO1
GoPubMedLINGO1
iHOPLINGO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:40:43 CEST 2017

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