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LINGO3 (leucine rich repeat and Ig domain containing 3)

Identity

Alias_namesLRRN6B
leucine rich repeat neuronal 6B
Alias_symbol (synonym)LERN2
Other alias
HGNC (Hugo) LINGO3
LocusID (NCBI) 645191
Atlas_Id 66112
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2289775 and ends at 2308157 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTBD2 (19p13.3) / LINGO3 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LINGO3   21206
Cards
Entrez_Gene (NCBI)LINGO3  645191  leucine rich repeat and Ig domain containing 3
AliasesLERN2; LRRN6B
GeneCards (Weizmann)LINGO3
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr19:2289775-2308157 [Contig_View]  LINGO3 [Vega]
TCGA cBioPortalLINGO3
AceView (NCBI)LINGO3
Genatlas (Paris)LINGO3
WikiGenes645191
SOURCE (Princeton)LINGO3
Genetics Home Reference (NIH)LINGO3
Genomic and cartography
GoldenPath hg38 (UCSC)LINGO3  -     chr19:2289775-2308157 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LINGO3  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblLINGO3 - 19p13.3 [CytoView hg19]  LINGO3 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBILINGO3 [Mapview hg19]  LINGO3 [Mapview hg38]
OMIM609792   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001101391
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LINGO3
Cluster EST : UnigeneHs.371587 [ NCBI ]
CGAP (NCI)Hs.371587
Gene ExpressionLINGO3 [ NCBI-GEO ]   LINGO3 [ EBI - ARRAY_EXPRESS ]   LINGO3 [ SEEK ]   LINGO3 [ MEM ]
Gene Expression Viewer (FireBrowse)LINGO3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)645191
GTEX Portal (Tissue expression)LINGO3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0C6S8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0C6S8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0C6S8
Splice isoforms : SwissVarP0C6S8
PhosPhoSitePlusP0C6S8
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRRNT   
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13855   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)LINGO3
DMDM Disease mutations645191
Blocks (Seattle)LINGO3
SuperfamilyP0C6S8
Peptide AtlasP0C6S8
IPIIPI00376131   
Protein Interaction databases
DIP (DOE-UCLA)P0C6S8
IntAct (EBI)P0C6S8
BioGRIDLINGO3
STRING (EMBL)LINGO3
ZODIACLINGO3
Ontologies - Pathways
QuickGOP0C6S8
Ontology : AmiGOproteinaceous extracellular matrix  extracellular space  axonogenesis  integral component of membrane  
Ontology : EGO-EBIproteinaceous extracellular matrix  extracellular space  axonogenesis  integral component of membrane  
NDEx NetworkLINGO3
Atlas of Cancer Signalling NetworkLINGO3
Wikipedia pathwaysLINGO3
Orthology - Evolution
OrthoDB645191
Phylogenetic Trees/Animal Genes : TreeFamLINGO3
HOVERGENP0C6S8
HOGENOMP0C6S8
Homologs : HomoloGeneLINGO3
Homology/Alignments : Family Browser (UCSC)LINGO3
Gene fusions - Rearrangements
Fusion: Tumor Portal LINGO3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLINGO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LINGO3
dbVarLINGO3
ClinVarLINGO3
1000_GenomesLINGO3 
Exome Variant ServerLINGO3
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP645191
Genomic Variants (DGV)LINGO3 [DGVbeta]
DECIPHERLINGO3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLINGO3 
Mutations
ICGC Data PortalLINGO3 
TCGA Data PortalLINGO3 
Broad Tumor PortalLINGO3
OASIS PortalLINGO3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLINGO3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLINGO3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LINGO3
DgiDB (Drug Gene Interaction Database)LINGO3
DoCM (Curated mutations)LINGO3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LINGO3 (select a term)
intoGenLINGO3
Cancer3DLINGO3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609792   
Orphanet
MedgenLINGO3
Genetic Testing Registry LINGO3
NextProtP0C6S8 [Medical]
TSGene645191
GENETestsLINGO3
Target ValidationLINGO3
Huge Navigator LINGO3 [HugePedia]
snp3D : Map Gene to Disease645191
BioCentury BCIQLINGO3
ClinGenLINGO3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD645191
Chemical/Pharm GKB GenePA162394097
Clinical trialLINGO3
Miscellaneous
canSAR (ICR)LINGO3 (select the gene name)
Probes
Litterature
PubMed3 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLINGO3
EVEXLINGO3
GoPubMedLINGO3
iHOPLINGO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:59:12 CET 2017

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