Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LIPC (lipase C, hepatic type)

Identity

Other namesHDLCQ12
HL
HTGL
LIPH
HGNC (Hugo) LIPC
LocusID (NCBI) 3990
Atlas_Id 43641
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 58724175 and ends at 58861073 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP8A1 (4p13) / LIPC (15q21.3)RPS11 (19q13.33) / LIPC (15q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIPC   6619
Cards
Entrez_Gene (NCBI)LIPC  3990  lipase C, hepatic type
AliasesHDLCQ12; HL; HTGL; LIPH
GeneCards (Weizmann)LIPC
Ensembl hg19 (Hinxton)ENSG00000166035 [Gene_View]  chr15:58724175-58861073 [Contig_View]  LIPC [Vega]
Ensembl hg38 (Hinxton)ENSG00000166035 [Gene_View]  chr15:58724175-58861073 [Contig_View]  LIPC [Vega]
ICGC DataPortalENSG00000166035
TCGA cBioPortalLIPC
AceView (NCBI)LIPC
Genatlas (Paris)LIPC
WikiGenes3990
SOURCE (Princeton)LIPC
Genomic and cartography
GoldenPath hg19 (UCSC)LIPC  -     chr15:58724175-58861073 +  15q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIPC  -     15q21.3   [Description]    (hg38-Dec_2013)
EnsemblLIPC - 15q21.3 [CytoView hg19]  LIPC - 15q21.3 [CytoView hg38]
Mapping of homologs : NCBILIPC [Mapview hg19]  LIPC [Mapview hg38]
OMIM125853   151670   612797   614025   
Gene and transcription
Genbank (Entrez)AI823349 AK290062 AK292631 AK293324 AK309448
RefSeq transcript (Entrez)NM_000236
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_011465 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)LIPC
Cluster EST : UnigeneHs.654472 [ NCBI ]
CGAP (NCI)Hs.654472
Alternative Splicing GalleryENSG00000166035
Gene ExpressionLIPC [ NCBI-GEO ]   LIPC [ EBI - ARRAY_EXPRESS ]   LIPC [ SEEK ]   LIPC [ MEM ]
Gene Expression Viewer (FireBrowse)LIPC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3990
GTEX Portal (Tissue expression)LIPC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11150 (Uniprot)
NextProtP11150  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11150
Splice isoforms : SwissVarP11150 (Swissvar)
Catalytic activity : Enzyme3.1.1.3 [ Enzyme-Expasy ]   3.1.1.33.1.1.3 [ IntEnz-EBI ]   3.1.1.3 [ BRENDA ]   3.1.1.3 [ KEGG ]   
PhosPhoSitePlusP11150
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)    PLAT (PS50095)   
Domains : Interpro (EBI)AB_hydrolase    Lipase_hep    Lipase_LIPH    Lipase_N    PLAT/LH2_dom    TAG_lipase   
Domain families : Pfam (Sanger)Lipase (PF00151)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00151    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
DMDM Disease mutations3990
Blocks (Seattle)LIPC
SuperfamilyP11150
Human Protein AtlasENSG00000166035
Peptide AtlasP11150
HPRD01058
IPIIPI00003882   IPI00854588   IPI00909632   
Protein Interaction databases
DIP (DOE-UCLA)P11150
IntAct (EBI)P11150
FunCoupENSG00000166035
BioGRIDLIPC
STRING (EMBL)LIPC
ZODIACLIPC
Ontologies - Pathways
QuickGOP11150
Ontology : AmiGOresponse to hypoxia  liver development  phospholipase activity  lysophospholipase activity  triglyceride lipase activity  triglyceride lipase activity  extracellular region  extracellular space  early endosome  late endosome  endoplasmic reticulum lumen  microvillus  fatty acid biosynthetic process  phosphatidylserine metabolic process  circadian rhythm  heparin binding  cholesterol metabolic process  lipid binding  phosphatidylcholine 1-acylhydrolase activity  response to carbohydrate  cell surface  response to acetate  heparan sulfate proteoglycan biosynthetic process  transferase activity, transferring acyl groups  triglyceride catabolic process  low-density lipoprotein particle binding  response to nutrient levels  response to magnesium ion  cellular response to hormone stimulus  apolipoprotein binding  high-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  intermediate-density lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron remnant clearance  low-density lipoprotein particle clearance  phosphatidylcholine catabolic process  response to drug  cholesterol homeostasis  response to amino acid  heparan sulfate proteoglycan binding  response to peptide hormone  reverse cholesterol transport  lipid digestion  phosphatidylethanolamine metabolic process  phosphatidic acid metabolic process  response to copper ion  acylglycerol lipase activity  developmental growth  protein oligomerization  response to glucocorticoid  response to calcium ion  triglyceride homeostasis  response to fatty acid  
Ontology : EGO-EBIresponse to hypoxia  liver development  phospholipase activity  lysophospholipase activity  triglyceride lipase activity  triglyceride lipase activity  extracellular region  extracellular space  early endosome  late endosome  endoplasmic reticulum lumen  microvillus  fatty acid biosynthetic process  phosphatidylserine metabolic process  circadian rhythm  heparin binding  cholesterol metabolic process  lipid binding  phosphatidylcholine 1-acylhydrolase activity  response to carbohydrate  cell surface  response to acetate  heparan sulfate proteoglycan biosynthetic process  transferase activity, transferring acyl groups  triglyceride catabolic process  low-density lipoprotein particle binding  response to nutrient levels  response to magnesium ion  cellular response to hormone stimulus  apolipoprotein binding  high-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  intermediate-density lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron remnant clearance  low-density lipoprotein particle clearance  phosphatidylcholine catabolic process  response to drug  cholesterol homeostasis  response to amino acid  heparan sulfate proteoglycan binding  response to peptide hormone  reverse cholesterol transport  lipid digestion  phosphatidylethanolamine metabolic process  phosphatidic acid metabolic process  response to copper ion  acylglycerol lipase activity  developmental growth  protein oligomerization  response to glucocorticoid  response to calcium ion  triglyceride homeostasis  response to fatty acid  
Pathways : KEGGGlycerolipid metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkLIPC
Wikipedia pathwaysLIPC
Orthology - Evolution
OrthoDB3990
GeneTree (enSembl)ENSG00000166035
Phylogenetic Trees/Animal Genes : TreeFamLIPC
Homologs : HomoloGeneLIPC
Homology/Alignments : Family Browser (UCSC)LIPC
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLIPC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIPC
dbVarLIPC
ClinVarLIPC
1000_GenomesLIPC 
Exome Variant ServerLIPC
ExAC (Exome Aggregation Consortium)LIPC (select the gene name)
Genetic variants : HAPMAP3990
Genomic Variants (DGV)LIPC [DGVbeta]
Mutations
ICGC Data PortalLIPC 
TCGA Data PortalLIPC 
Broad Tumor PortalLIPC
OASIS PortalLIPC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIPC 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LIPC
DgiDB (Drug Gene Interaction Database)LIPC
DoCM (Curated mutations)LIPC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIPC (select a term)
intoGenLIPC
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:58724175-58861073  ENSG00000166035
CONAN: Copy Number AnalysisLIPC 
Mutations and Diseases : HGMDLIPC
OMIM125853    151670    612797    614025   
MedgenLIPC
Genetic Testing Registry LIPC
NextProtP11150 [Medical]
TSGene3990
GENETestsLIPC
Huge Navigator LIPC [HugePedia]
snp3D : Map Gene to Disease3990
BioCentury BCIQLIPC
ClinGenLIPC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3990
Chemical/Pharm GKB GenePA230
Clinical trialLIPC
Miscellaneous
canSAR (ICR)LIPC (select the gene name)
Probes
Litterature
PubMed302 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIPC
EVEXLIPC
GoPubMedLIPC
iHOPLIPC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:12 CEST 2016

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