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LIPC (lipase C, hepatic type)

Identity

Alias_nameslipase
Alias_symbol (synonym)HL
HTGL
Other aliasHDLCQ12
LIPH
HGNC (Hugo) LIPC
LocusID (NCBI) 3990
Atlas_Id 43641
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 58431976 and ends at 58568874 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP8A1 (4p13) / LIPC (15q21.3)RPS11 (19q13.33) / LIPC (15q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIPC   6619
Cards
Entrez_Gene (NCBI)LIPC  3990  lipase C, hepatic type
AliasesHDLCQ12; HL; HTGL; LIPH
GeneCards (Weizmann)LIPC
Ensembl hg19 (Hinxton)ENSG00000166035 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166035 [Gene_View]  chr15:58431976-58568874 [Contig_View]  LIPC [Vega]
ICGC DataPortalENSG00000166035
TCGA cBioPortalLIPC
AceView (NCBI)LIPC
Genatlas (Paris)LIPC
WikiGenes3990
SOURCE (Princeton)LIPC
Genetics Home Reference (NIH)LIPC
Genomic and cartography
GoldenPath hg38 (UCSC)LIPC  -     chr15:58431976-58568874 +  15q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LIPC  -     15q21.3   [Description]    (hg19-Feb_2009)
EnsemblLIPC - 15q21.3 [CytoView hg19]  LIPC - 15q21.3 [CytoView hg38]
Mapping of homologs : NCBILIPC [Mapview hg19]  LIPC [Mapview hg38]
OMIM125853   151670   612797   614025   
Gene and transcription
Genbank (Entrez)AI823349 AK290062 AK292631 AK293324 AK309448
RefSeq transcript (Entrez)NM_000236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LIPC
Cluster EST : UnigeneHs.654472 [ NCBI ]
CGAP (NCI)Hs.654472
Alternative Splicing GalleryENSG00000166035
Gene ExpressionLIPC [ NCBI-GEO ]   LIPC [ EBI - ARRAY_EXPRESS ]   LIPC [ SEEK ]   LIPC [ MEM ]
Gene Expression Viewer (FireBrowse)LIPC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3990
GTEX Portal (Tissue expression)LIPC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11150   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11150  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11150
Splice isoforms : SwissVarP11150
Catalytic activity : Enzyme3.1.1.3 [ Enzyme-Expasy ]   3.1.1.33.1.1.3 [ IntEnz-EBI ]   3.1.1.3 [ BRENDA ]   3.1.1.3 [ KEGG ]   
PhosPhoSitePlusP11150
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)    PLAT (PS50095)   
Domains : Interpro (EBI)AB_hydrolase    Lipase/vitellogenin    Lipase_hep    Lipase_LIPH    Lipase_N    PLAT/LH2_dom    TAG_lipase   
Domain families : Pfam (Sanger)Lipase (PF00151)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00151    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)LIPC
DMDM Disease mutations3990
Blocks (Seattle)LIPC
SuperfamilyP11150
Human Protein AtlasENSG00000166035
Peptide AtlasP11150
HPRD01058
IPIIPI00003882   IPI00854588   IPI00909632   
Protein Interaction databases
DIP (DOE-UCLA)P11150
IntAct (EBI)P11150
FunCoupENSG00000166035
BioGRIDLIPC
STRING (EMBL)LIPC
ZODIACLIPC
Ontologies - Pathways
QuickGOP11150
Ontology : AmiGOphospholipase activity  triglyceride lipase activity  triglyceride lipase activity  extracellular region  extracellular space  endoplasmic reticulum lumen  fatty acid biosynthetic process  heparin binding  cholesterol metabolic process  triglyceride catabolic process  low-density lipoprotein particle binding  apolipoprotein binding  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  intermediate-density lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron remnant clearance  phosphatidylcholine catabolic process  cholesterol homeostasis  reverse cholesterol transport  lipid digestion  triglyceride homeostasis  
Ontology : EGO-EBIphospholipase activity  triglyceride lipase activity  triglyceride lipase activity  extracellular region  extracellular space  endoplasmic reticulum lumen  fatty acid biosynthetic process  heparin binding  cholesterol metabolic process  triglyceride catabolic process  low-density lipoprotein particle binding  apolipoprotein binding  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  intermediate-density lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron remnant clearance  phosphatidylcholine catabolic process  cholesterol homeostasis  reverse cholesterol transport  lipid digestion  triglyceride homeostasis  
Pathways : KEGGGlycerolipid metabolism   
NDEx NetworkLIPC
Atlas of Cancer Signalling NetworkLIPC
Wikipedia pathwaysLIPC
Orthology - Evolution
OrthoDB3990
GeneTree (enSembl)ENSG00000166035
Phylogenetic Trees/Animal Genes : TreeFamLIPC
HOVERGENP11150
HOGENOMP11150
Homologs : HomoloGeneLIPC
Homology/Alignments : Family Browser (UCSC)LIPC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIPC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIPC
dbVarLIPC
ClinVarLIPC
1000_GenomesLIPC 
Exome Variant ServerLIPC
ExAC (Exome Aggregation Consortium)LIPC (select the gene name)
Genetic variants : HAPMAP3990
Genomic Variants (DGV)LIPC [DGVbeta]
DECIPHERLIPC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLIPC 
Mutations
ICGC Data PortalLIPC 
TCGA Data PortalLIPC 
Broad Tumor PortalLIPC
OASIS PortalLIPC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIPC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLIPC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LIPC
DgiDB (Drug Gene Interaction Database)LIPC
DoCM (Curated mutations)LIPC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIPC (select a term)
intoGenLIPC
Cancer3DLIPC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    151670    612797    614025   
Orphanet16994   
MedgenLIPC
Genetic Testing Registry LIPC
NextProtP11150 [Medical]
TSGene3990
GENETestsLIPC
Target ValidationLIPC
Huge Navigator LIPC [HugePedia]
snp3D : Map Gene to Disease3990
BioCentury BCIQLIPC
ClinGenLIPC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3990
Chemical/Pharm GKB GenePA230
Clinical trialLIPC
Miscellaneous
canSAR (ICR)LIPC (select the gene name)
Probes
Litterature
PubMed306 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIPC
EVEXLIPC
GoPubMedLIPC
iHOPLIPC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:57:46 CEST 2017

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