LLGL2 (LLGL scribble cell polarity complex component 2)

2003-12-01  

Identity

HGNC
LLGL2
LOCATION
17q25.1
LOCUSID
3993
ALIAS
HGL,Hugl-2,LGL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3993
MIM: 618483
HGNC: 6629
Ensembl: ENSG00000073350

Variants:

dbSNP: 3993
ClinVar: 3993
TCGA: ENSG00000073350
COSMIC: LLGL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073350ENST00000167462Q6P1M3
ENSG00000073350ENST00000375227Q6P1M3
ENSG00000073350ENST00000392550Q6P1M3
ENSG00000073350ENST00000577200J3QRV5
ENSG00000073350ENST00000578363Q6P1M3
ENSG00000073350ENST00000578536J3QRZ8
ENSG00000073350ENST00000578638J3QLD8
ENSG00000073350ENST00000578719J3QKM6
ENSG00000073350ENST00000579392J3QLV4
ENSG00000073350ENST00000580578J3QSA6
ENSG00000073350ENST00000580925J3KRE1
ENSG00000073350ENST00000581713J3QL58
ENSG00000073350ENST00000583514J3KSD5
ENSG00000073350ENST00000583658J3QS20

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
181995502008The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.218
194031352009Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study.36
156322022005Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.22
245138552014Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl.18
194078522009Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study.14
231100972012Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.13
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
225806092013The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis.10
309963452019LLGL2 rescues nutrient stress by promoting leucine uptake in ER<sup>+</sup> breast cancer.10
209415062010Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta.6

Citation

Dessen P

LLGL2 (LLGL scribble cell polarity complex component 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41163/llgl2