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LLGL2 (LLGL2, scribble cell polarity complex component)

Identity

Alias_nameslethal giant larvae homolog 2 (Drosophila)
lethal giant larvae homolog 2, scribble cell polarity complex component
Alias_symbol (synonym)HGL
Hugl-2
Other aliasLGL2
HGNC (Hugo) LLGL2
LocusID (NCBI) 3993
Atlas_Id 41163
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75525702 and ends at 75564723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KAZN (1p36.21) / LLGL2 (17q25.1)LLGL2 (17q25.1) / CA10 (17q21.33)LLGL2 (17q25.1) / CPNE4 (3q22.1)
LLGL2 (17q25.1) / PXN (12q24.23)LLGL2 (17q25.1) / SORBS1 (10q24.1)LLGL2 (17q25.1) / XRCC1 (19q13.31)
LLGL2 17q25.1 / CPNE4 3q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LLGL2   6629
Cards
Entrez_Gene (NCBI)LLGL2  3993  LLGL2, scribble cell polarity complex component
AliasesHGL; Hugl-2; LGL2
GeneCards (Weizmann)LLGL2
Ensembl hg19 (Hinxton)ENSG00000073350 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073350 [Gene_View]  chr17:75525702-75564723 [Contig_View]  LLGL2 [Vega]
ICGC DataPortalENSG00000073350
TCGA cBioPortalLLGL2
AceView (NCBI)LLGL2
Genatlas (Paris)LLGL2
WikiGenes3993
SOURCE (Princeton)LLGL2
Genetics Home Reference (NIH)LLGL2
Genomic and cartography
GoldenPath hg38 (UCSC)LLGL2  -     chr17:75525702-75564723 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LLGL2  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblLLGL2 - 17q25.1 [CytoView hg19]  LLGL2 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBILLGL2 [Mapview hg19]  LLGL2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK025401 AK125563 AK126687 AK301204 AK315126
RefSeq transcript (Entrez)NM_001015002 NM_001031803 NM_004524
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LLGL2
Cluster EST : UnigeneHs.514477 [ NCBI ]
CGAP (NCI)Hs.514477
Alternative Splicing GalleryENSG00000073350
Gene ExpressionLLGL2 [ NCBI-GEO ]   LLGL2 [ EBI - ARRAY_EXPRESS ]   LLGL2 [ SEEK ]   LLGL2 [ MEM ]
Gene Expression Viewer (FireBrowse)LLGL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3993
GTEX Portal (Tissue expression)LLGL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P1M3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P1M3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P1M3
Splice isoforms : SwissVarQ6P1M3
PhosPhoSitePlusQ6P1M3
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)   
Domains : Interpro (EBI)Lethal2_giant    LLGL2    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)LLGL (PF08366)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam08366    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)LLGL2
DMDM Disease mutations3993
Blocks (Seattle)LLGL2
PDB (SRS)3WP0    3WP1   
PDB (PDBSum)3WP0    3WP1   
PDB (IMB)3WP0    3WP1   
PDB (RSDB)3WP0    3WP1   
Structural Biology KnowledgeBase3WP0    3WP1   
SCOP (Structural Classification of Proteins)3WP0    3WP1   
CATH (Classification of proteins structures)3WP0    3WP1   
SuperfamilyQ6P1M3
Human Protein AtlasENSG00000073350
Peptide AtlasQ6P1M3
HPRD10041
IPIIPI00465050   IPI00641801   IPI01009129   IPI00555972   
Protein Interaction databases
DIP (DOE-UCLA)Q6P1M3
IntAct (EBI)Q6P1M3
FunCoupENSG00000073350
BioGRIDLLGL2
STRING (EMBL)LLGL2
ZODIACLLGL2
Ontologies - Pathways
QuickGOQ6P1M3
Ontology : AmiGOGTPase activator activity  protein binding  cytoplasm  cytosol  plasma membrane  exocytosis  cell cycle  Rab GTPase binding  regulation of exocytosis  syntaxin binding  PDZ domain binding  regulation of establishment or maintenance of cell polarity  intracellular membrane-bounded organelle  positive regulation of GTPase activity  regulation of protein secretion  cell division  
Ontology : EGO-EBIGTPase activator activity  protein binding  cytoplasm  cytosol  plasma membrane  exocytosis  cell cycle  Rab GTPase binding  regulation of exocytosis  syntaxin binding  PDZ domain binding  regulation of establishment or maintenance of cell polarity  intracellular membrane-bounded organelle  positive regulation of GTPase activity  regulation of protein secretion  cell division  
Pathways : KEGGHippo signaling pathway    Tight junction   
NDEx NetworkLLGL2
Atlas of Cancer Signalling NetworkLLGL2
Wikipedia pathwaysLLGL2
Orthology - Evolution
OrthoDB3993
GeneTree (enSembl)ENSG00000073350
Phylogenetic Trees/Animal Genes : TreeFamLLGL2
HOVERGENQ6P1M3
HOGENOMQ6P1M3
Homologs : HomoloGeneLLGL2
Homology/Alignments : Family Browser (UCSC)LLGL2
Gene fusions - Rearrangements
Fusion : MitelmanLLGL2/CA10 [17q25.1/17q21.33]  
Fusion : MitelmanLLGL2/CPNE4 [17q25.1/3q22.1]  [t(3;17)(q22;q25)]  
Fusion: TCGALLGL2 17q25.1 CPNE4 3q22.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLLGL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LLGL2
dbVarLLGL2
ClinVarLLGL2
1000_GenomesLLGL2 
Exome Variant ServerLLGL2
ExAC (Exome Aggregation Consortium)LLGL2 (select the gene name)
Genetic variants : HAPMAP3993
Genomic Variants (DGV)LLGL2 [DGVbeta]
DECIPHERLLGL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLLGL2 
Mutations
ICGC Data PortalLLGL2 
TCGA Data PortalLLGL2 
Broad Tumor PortalLLGL2
OASIS PortalLLGL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLLGL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLLGL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LLGL2
DgiDB (Drug Gene Interaction Database)LLGL2
DoCM (Curated mutations)LLGL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LLGL2 (select a term)
intoGenLLGL2
Cancer3DLLGL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenLLGL2
Genetic Testing Registry LLGL2
NextProtQ6P1M3 [Medical]
TSGene3993
GENETestsLLGL2
Huge Navigator LLGL2 [HugePedia]
snp3D : Map Gene to Disease3993
BioCentury BCIQLLGL2
ClinGenLLGL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3993
Chemical/Pharm GKB GenePA30397
Clinical trialLLGL2
Miscellaneous
canSAR (ICR)LLGL2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLLGL2
EVEXLLGL2
GoPubMedLLGL2
iHOPLLGL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:22:42 CEST 2017

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