LMAN2 (lectin, mannose binding 2)

2012-11-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
C5orf8,GP36B,VIP36
FUSION GENES

Other Information

Locus ID:

NCBI: 10960
MIM: 609551
HGNC: 16986
Ensembl: ENSG00000169223

Variants:

dbSNP: 10960
ClinVar: 10960
TCGA: ENSG00000169223
COSMIC: LMAN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169223ENST00000303127Q12907
ENSG00000169223ENST00000303127A0A384NPY7
ENSG00000169223ENST00000502560D6RDX1
ENSG00000169223ENST00000513877D6RIU4
ENSG00000169223ENST00000514458D6RBH1
ENSG00000169223ENST00000515209D6RBV2

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180250802008Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36.40
204779882010Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin.16
113599372001Quantitative ER <--> Golgi transport kinetics and protein separation upon Golgi exit revealed by vesicular integral membrane protein 36 dynamics in live cells.8
175865392007Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP.8
277658172016Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.8
232696692013Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.5

Citation

Dessen P

LMAN2 (lectin, mannose binding 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53019/lman2